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Murcko scaffold

Ring system with 3 rings and 17 atoms

29 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 17
Chemicals: 29
With full pages: 5

Scaffold SMILES

O=c1c2ccsc2ncn1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1c2ccsc2ncn1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

Ethyl 3-[(4-fluorophenyl)methyl]-5-methyl-4-oxothieno[2,3-d]pyrimidine-6-carboxylate chemical structure, C17H15FN2O3S, CAS 449190-55-0

Ethyl 3-[(4-fluorophenyl)methyl]-5-methyl-4-oxothieno[2,3-d]pyrimidine-6-carboxylate

CAS 449190-55-0C₁₇H₁₅FN₂O₃S

Ethyl 5-methyl-3-(3-methylbenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate chemical structure, C18H18N2O3S, CAS 459418-46-3

Ethyl 5-methyl-3-(3-methylbenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate

CAS 459418-46-3C₁₈H₁₈N₂O₃S

Methyl 4-[(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3-yl)methyl]benzoate chemical structure, C17H16N2O3S, CAS 457910-75-7

Methyl 4-[(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3-yl)methyl]benzoate

CAS 457910-75-7C₁₇H₁₆N₂O₃S

3-(2,6-Dichlorobenzyl)-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C15H12Cl2N2OS, CAS 450393-93-8

3-(2,6-Dichlorobenzyl)-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one

CAS 450393-93-8C₁₅H₁₂Cl₂N₂OS

3-[(2-Chlorophenyl)methyl]-5-methyl-4-oxothieno[2,3-d]pyrimidine-6-carboxamide chemical structure, C15H12ClN3O2S, CAS 691862-38-1

3-[(2-Chlorophenyl)methyl]-5-methyl-4-oxothieno[2,3-d]pyrimidine-6-carboxamide

CAS 691862-38-1C₁₅H₁₂ClN₃O₂S

3-(2-Chlorobenzyl)-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C15H13ClN2OS, CAS 403716-51-8

3-(2-Chlorobenzyl)-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one

CAS 403716-51-8C₁₅H₁₃ClN₂OS

Ethyl 3-(4-bromobenzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate chemical structure, C17H15BrN2O3S, CAS 433966-24-6

Ethyl 3-(4-bromobenzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate

CAS 433966-24-6C₁₇H₁₅BrN₂O₃S

5,6-Dimethyl-3-[(3-methylphenyl)methyl]thieno[2,3-d]pyrimidin-4-one chemical structure, C16H16N2OS, CAS 433256-51-0

5,6-Dimethyl-3-[(3-methylphenyl)methyl]thieno[2,3-d]pyrimidin-4-one

CAS 433256-51-0C₁₆H₁₆N₂OS

N-(2-Cyano-3-methylbutan-2-yl)-2-((6-ethyl-5-methyl-3-(4-methylbenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamide chemical structure, C25H30N4O2S2, CAS 781631-52-5

N-(2-Cyano-3-methylbutan-2-yl)-2-((6-ethyl-5-methyl-3-(4-methylbenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamide

CAS 781631-52-5C₂₅H₃₀N₄O₂S₂

3-(4-Chlorobenzyl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C13H9ClN2OS, CAS 338777-24-5

3-(4-Chlorobenzyl)thieno[2,3-d]pyrimidin-4(3H)-one

CAS 338777-24-5C₁₃H₉ClN₂OS

3-(4-Methoxybenzyl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C14H12N2O2S, CAS 338777-25-6

3-(4-Methoxybenzyl)thieno[2,3-d]pyrimidin-4(3H)-one

CAS 338777-25-6C₁₄H₁₂N₂O₂S

3-(2-Fluorobenzyl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C13H9FN2OS, CAS 338777-26-7

3-(2-Fluorobenzyl)thieno[2,3-d]pyrimidin-4(3H)-one

CAS 338777-26-7C₁₃H₉FN₂OS

3-[3-(Trifluoromethyl)benzyl]thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C14H9F3N2OS, CAS 338777-27-8

3-[3-(Trifluoromethyl)benzyl]thieno[2,3-d]pyrimidin-4(3H)-one

CAS 338777-27-8C₁₄H₉F₃N₂OS

3-(3-Methylbenzyl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C14H12N2OS, CAS 338777-28-9

3-(3-Methylbenzyl)thieno[2,3-d]pyrimidin-4(3H)-one

CAS 338777-28-9C₁₄H₁₂N₂OS

2-({3-Benzyl-5,6-dimethyl-4-oxo-3H,4H-thieno[2,3-d]pyrimidin-2-yl}sulfanyl)-N-(1-cyano-1,2-dimethylpropyl)acetamide chemical structure, C23H26N4O2S2, CAS 744268-04-0

2-({3-Benzyl-5,6-dimethyl-4-oxo-3H,4H-thieno[2,3-d]pyrimidin-2-yl}sulfanyl)-N-(1-cyano-1,2-dimethylpropyl)acetamide

CAS 744268-04-0C₂₃H₂₆N₄O₂S₂

3-(3-Fluorobenzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid chemical structure, C15H11FN2O3S, CAS 450356-14-6

3-(3-Fluorobenzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid

CAS 450356-14-6C₁₅H₁₁FN₂O₃S

3-(4-Chlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid chemical structure, C15H11ClN2O3S, CAS 943108-91-6

3-(4-Chlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid

CAS 943108-91-6C₁₅H₁₁ClN₂O₃S

3-[(3-Chlorophenyl)methyl]-2,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C16H15ClN2OS, CAS 943109-77-1

3-[(3-Chlorophenyl)methyl]-2,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one

CAS 943109-77-1C₁₆H₁₅ClN₂OS

3-Benzyl-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid chemical structure, C15H12N2O3S, CAS 1050084-33-7

3-Benzyl-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid

CAS 1050084-33-7C₁₅H₁₂N₂O₃S

5,6-Dimethyl-3-[4-(trifluoromethoxy)benzyl]thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C16H13F3N2O2S, CAS 1282110-44-4

5,6-Dimethyl-3-[4-(trifluoromethoxy)benzyl]thieno[2,3-d]pyrimidin-4(3H)-one

CAS 1282110-44-4C₁₆H₁₃F₃N₂O₂S

3-(3-Fluorobenzyl)-5-methyl-N-(2-methylpropyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide chemical structure, C19H20FN3O2S, CAS 1190241-89-4

3-(3-Fluorobenzyl)-5-methyl-N-(2-methylpropyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide

CAS 1190241-89-4C₁₉H₂₀FN₃O₂S

Methyl N-{[3-(4-chlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl]carbonyl}glycinate chemical structure, C18H16ClN3O4S, CAS 1190243-17-4

Methyl N-{[3-(4-chlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl]carbonyl}glycinate

CAS 1190243-17-4C₁₈H₁₆ClN₃O₄S

3-Benzyl-5-methyl-4-oxo-N-(propan-2-yl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide chemical structure, C18H19N3O2S, CAS 1190261-34-7

3-Benzyl-5-methyl-4-oxo-N-(propan-2-yl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide

CAS 1190261-34-7C₁₈H₁₉N₃O₂S

2-[(2-Chloro-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)methyl]benzonitrile chemical structure, C14H8ClN3OS, CAS 1265593-73-4

2-[(2-Chloro-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)methyl]benzonitrile

CAS 1265593-73-4C₁₄H₈ClN₃OS