Murcko scaffold
Ring system with 3 rings and 24 atoms
85 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 24
- Chemicals
- 85
- With full pages
- 3
Scaffold SMILES
O=C(Cn1cc(C(=O)Nc2ccccc2)nn1)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 85 chemicals
![5-Amino-N-(3,4-dimethylphenyl)-1-{[(2-methoxyphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide chemical structure, C20H22N6O3, CAS 865655-72-7](/s/UIDSEKCQFTYPBS-UHFFFAOYSA-N.svg)
5-Amino-N-(3,4-dimethylphenyl)-1-{[(2-methoxyphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide
CAS 865655-72-7C20H22N6O3
![5-Amino-N-(5-chloro-2-methoxyphenyl)-1-[(phenylcarbamoyl)methyl]-1H-1,2,3-triazole-4-carboxamide chemical structure, C18H17ClN6O3, CAS 866013-83-4](/s/MBZMOSDWFPZCJL-UHFFFAOYSA-N.svg)
5-Amino-N-(5-chloro-2-methoxyphenyl)-1-[(phenylcarbamoyl)methyl]-1H-1,2,3-triazole-4-carboxamide
CAS 866013-83-4C18H17ClN6O3
5-Amino-N-(5-chloro-2-methoxyphenyl)-1-(2-((4-methoxyphenyl)amino)-2-oxoethyl)-1H-1,2,3-triazole-4-carboxamide
CAS 866013-85-6C19H19ClN6O4
![5-Amino-N-(3-fluorophenyl)-1-{[(2-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide chemical structure, C18H17FN6O2, CAS 866013-89-0](/s/CVXWQPGFHXRQHR-UHFFFAOYSA-N.svg)
5-Amino-N-(3-fluorophenyl)-1-{[(2-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide
CAS 866013-89-0C18H17FN6O2
![5-Amino-N-(3,4-dimethylphenyl)-1-{[(2-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide chemical structure, C20H22N6O2, CAS 866013-91-4](/s/WPSASCXQTHJZPY-UHFFFAOYSA-N.svg)
5-Amino-N-(3,4-dimethylphenyl)-1-{[(2-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide
CAS 866013-91-4C20H22N6O2
![5-Amino-N-(2-methylphenyl)-1-{[(2-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide chemical structure, C19H20N6O2, CAS 866013-93-6](/s/DYYDDGRWJKGSGK-UHFFFAOYSA-N.svg)
5-Amino-N-(2-methylphenyl)-1-{[(2-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide
CAS 866013-93-6C19H20N6O2
![5-Amino-N-(4-ethylphenyl)-1-[2-(2-methylanilino)-2-oxoethyl]triazole-4-carboxamide chemical structure, C20H22N6O2, CAS 866013-95-8](/s/SDUOEODQRUOOFI-UHFFFAOYSA-N.svg)
5-Amino-N-(4-ethylphenyl)-1-[2-(2-methylanilino)-2-oxoethyl]triazole-4-carboxamide
CAS 866013-95-8C20H22N6O2
![5-Amino-N-(3,4-dimethylphenyl)-1-{[(3-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide chemical structure, C20H22N6O2, CAS 866014-06-4](/s/NEIGSXHQGAWWLH-UHFFFAOYSA-N.svg)
5-Amino-N-(3,4-dimethylphenyl)-1-{[(3-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide
CAS 866014-06-4C20H22N6O2
![5-Amino-N-(2-methoxyphenyl)-1-{[(3-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide chemical structure, C19H20N6O3, CAS 866014-08-6](/s/LAZFKJRQSHEURT-UHFFFAOYSA-N.svg)
5-Amino-N-(2-methoxyphenyl)-1-{[(3-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide
CAS 866014-08-6C19H20N6O3
![5-Amino-N-(4-ethylphenyl)-1-{[(3-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide chemical structure, C20H22N6O2, CAS 866014-10-0](/s/DCLBMFGKMFIOCZ-UHFFFAOYSA-N.svg)
5-Amino-N-(4-ethylphenyl)-1-{[(3-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide
CAS 866014-10-0C20H22N6O2
![5-Amino-N-(5-chloro-2-methoxyphenyl)-1-[2-(3-methylanilino)-2-oxoethyl]triazole-4-carboxamide chemical structure, C19H19ClN6O3, CAS 866014-12-2](/s/BPTFHUYAUTXVNU-UHFFFAOYSA-N.svg)
5-Amino-N-(5-chloro-2-methoxyphenyl)-1-[2-(3-methylanilino)-2-oxoethyl]triazole-4-carboxamide
CAS 866014-12-2C19H19ClN6O3
5-Amino-1-(2-((3-chloro-4-methoxyphenyl)amino)-2-oxoethyl)-N-(2-methoxyphenyl)-1H-1,2,3-triazole-4-carboxamide
CAS 866014-29-1C19H19ClN6O4
![5-Amino-N-(3,4-dimethylphenyl)-1-[2-(4-ethoxyanilino)-2-oxoethyl]triazole-4-carboxamide chemical structure, C21H24N6O3, CAS 866016-32-2](/s/ZDVDZVWYURBTMR-UHFFFAOYSA-N.svg)
5-Amino-N-(3,4-dimethylphenyl)-1-[2-(4-ethoxyanilino)-2-oxoethyl]triazole-4-carboxamide
CAS 866016-32-2C21H24N6O3
5-Amino-N-(3,4-dimethylphenyl)-1-(2-((2,5-dimethylphenyl)amino)-2-oxoethyl)-1H-1,2,3-triazole-4-carboxamide
CAS 866016-34-4C21H24N6O2
![5-Amino-1-[2-(2-ethylanilino)-2-oxoethyl]-N-(2-ethylphenyl)triazole-4-carboxamide chemical structure, C21H24N6O2, CAS 866016-36-6](/s/JMTQTWVHPJEIPV-UHFFFAOYSA-N.svg)
5-Amino-1-[2-(2-ethylanilino)-2-oxoethyl]-N-(2-ethylphenyl)triazole-4-carboxamide
CAS 866016-36-6C21H24N6O2
![5-Amino-1-[2-(3,4-dimethylanilino)-2-oxoethyl]-N-(2-ethoxyphenyl)triazole-4-carboxamide chemical structure, C21H24N6O3, CAS 866345-77-9](/s/UNLVWIPAEDULQZ-UHFFFAOYSA-N.svg)
5-Amino-1-[2-(3,4-dimethylanilino)-2-oxoethyl]-N-(2-ethoxyphenyl)triazole-4-carboxamide
CAS 866345-77-9C21H24N6O3
![5-Amino-1-[2-(2,4-dimethylanilino)-2-oxoethyl]-N-(3-fluorophenyl)triazole-4-carboxamide chemical structure, C19H19FN6O2, CAS 866345-82-6](/s/SRMBDZBAIQRQMR-UHFFFAOYSA-N.svg)
5-Amino-1-[2-(2,4-dimethylanilino)-2-oxoethyl]-N-(3-fluorophenyl)triazole-4-carboxamide
CAS 866345-82-6C19H19FN6O2
![5-Amino-1-{[(2-methoxyphenyl)carbamoyl]methyl}-N-phenyl-1H-1,2,3-triazole-4-carboxamide chemical structure, C18H18N6O3, CAS 901017-85-4](/s/CBHQLVSKRVBYFX-UHFFFAOYSA-N.svg)
5-Amino-1-{[(2-methoxyphenyl)carbamoyl]methyl}-N-phenyl-1H-1,2,3-triazole-4-carboxamide
CAS 901017-85-4C18H18N6O3
![5-Amino-N-phenyl-1-[(phenylcarbamoyl)methyl]-1H-1,2,3-triazole-4-carboxamide chemical structure, C17H16N6O2, CAS 931363-57-4](/s/SYDOINTZJLZUDP-UHFFFAOYSA-N.svg)
5-Amino-N-phenyl-1-[(phenylcarbamoyl)methyl]-1H-1,2,3-triazole-4-carboxamide
CAS 931363-57-4C17H16N6O2
![5-Amino-N-(5-chloro-2-methoxyphenyl)-1-[2-(2,6-dimethylanilino)-2-oxoethyl]triazole-4-carboxamide chemical structure, C20H21ClN6O3, CAS 895651-51-1](/s/GCWCSPLSSDPUOO-UHFFFAOYSA-N.svg)
5-Amino-N-(5-chloro-2-methoxyphenyl)-1-[2-(2,6-dimethylanilino)-2-oxoethyl]triazole-4-carboxamide
CAS 895651-51-1C20H21ClN6O3
5-Amino-1-(2-((4-ethoxyphenyl)amino)-2-oxoethyl)-N-(4-ethylphenyl)-1H-1,2,3-triazole-4-carboxamide
CAS 865655-18-1C21H24N6O3
5-Amino-N-(3,5-dimethylphenyl)-1-(2-(mesitylamino)-2-oxoethyl)-1H-1,2,3-triazole-4-carboxamide
CAS 899213-34-4C22H26N6O2
![5-Amino-N-(3,4-dimethylphenyl)-1-{[(2-ethoxyphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide chemical structure, C21H24N6O3, CAS 901045-67-8](/s/MZVUGZXMOKUFDC-UHFFFAOYSA-N.svg)
5-Amino-N-(3,4-dimethylphenyl)-1-{[(2-ethoxyphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide
CAS 901045-67-8C21H24N6O3
![5-Amino-N-(2-bromophenyl)-1-{2-[(2-methoxyphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxamide chemical structure, C18H17BrN6O3, CAS 894594-33-3](/s/DUOOUGSCXXBOIZ-UHFFFAOYSA-N.svg)
5-Amino-N-(2-bromophenyl)-1-{2-[(2-methoxyphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxamide
CAS 894594-33-3C18H17BrN6O3
- 5-Amino-N-(2,4-dimethoxyphenyl)-1-{2-[(2,3-dimethylphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxamide894564-53-5C21H24N6O4
- 5-Amino-N-(2,5-dimethylphenyl)-1-{2-[(2,3-dimethylphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxamide894584-66-8C21H24N6O2
- 5-Amino-1-{2-[(4-methoxyphenyl)amino]-2-oxoethyl}-N-(2-methylphenyl)-1H-1,2,3-triazole-4-carboxamide901018-27-7C19H20N6O3
- 5-Amino-N-(5-chloro-2-methoxyphenyl)-1-{[(2-ethoxyphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide865655-16-9C20H21ClN6O4
- 5-Amino-N-(4-bromophenyl)-1-{[(2,4,6-trimethylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide899213-38-8C20H21BrN6O2
- 5-Amino-N-(2,5-diethoxyphenyl)-1-{[(2,4,6-trimethylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide899213-43-5C24H30N6O4
- 5-Amino-N-(3,4-dimethoxyphenyl)-1-{[(2,4-dimethylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide899214-65-4C21H24N6O4
- 5-Amino-N-(2,4-dimethoxyphenyl)-1-{[(2,4-dimethylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide899214-66-5C21H24N6O4
- 5-Amino-N-(3,5-dimethoxyphenyl)-1-{[(3,5-dimethylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide899213-60-6C21H24N6O4
- 5-Amino-N-(5-chloro-2-methoxyphenyl)-1-{[(2,3-dimethylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide895651-60-2C20H21ClN6O3
- 5-Amino-N-(5-chloro-2-methoxyphenyl)-1-(2-((2-ethylphenyl)amino)-2-oxoethyl)-1H-1,2,3-triazole-4-carboxamide895651-74-8C20H21ClN6O3
- 5-Amino-N-(5-chloro-2-methoxyphenyl)-1-{[(4-ethylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide895651-82-8C20H21ClN6O3
- 5-Amino-N-(4-methylphenyl)-1-[2-oxo-2-(phenylamino)ethyl]-1H-1,2,3-triazole-4-carboxamide901017-55-8C18H18N6O2
- 5-Amino-N-(2-fluorophenyl)-1-[2-oxo-2-(phenylamino)ethyl]-1H-1,2,3-triazole-4-carboxamide901017-57-0C17H15FN6O2
- 5-Amino-N-(3-fluorophenyl)-1-[(phenylcarbamoyl)methyl]-1H-1,2,3-triazole-4-carboxamide931720-50-2C17H15FN6O2
- 5-Amino-N-(2-methylphenyl)-1-[2-oxo-2-(phenylamino)ethyl]-1H-1,2,3-triazole-4-carboxamide901017-63-8C18H18N6O2
- 5-Amino-N-(2-ethoxyphenyl)-1-[2-oxo-2-(phenylamino)ethyl]-1H-1,2,3-triazole-4-carboxamide901017-67-2C19H20N6O3
- 5-Amino-1-{[(2-methoxyphenyl)carbamoyl]methyl}-N-(4-methylphenyl)-1H-1,2,3-triazole-4-carboxamide901017-89-8C19H20N6O3
- 5-Amino-N-(2-ethylphenyl)-1-{[(2-methoxyphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide901017-93-4C20H22N6O3
- 5-Amino-1-{2-[(2-methoxyphenyl)amino]-2-oxoethyl}-N-(2-methylphenyl)-1H-1,2,3-triazole-4-carboxamide901017-99-0C19H20N6O3
- 5-Amino-1-{[(4-methoxyphenyl)carbamoyl]methyl}-N-(4-methylphenyl)-1H-1,2,3-triazole-4-carboxamide901018-17-5C19H20N6O3
- 5-Amino-N-(2-fluorophenyl)-1-{[(4-methoxyphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide901018-19-7C18H17FN6O3
- 5-Amino-N-(2-methoxyphenyl)-1-{[(2-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide901018-57-3C19H20N6O3
- 5-Amino-N-(2-chlorophenyl)-1-{[(2-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxamide901018-59-5C18H17ClN6O2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(NCc1nnc(SCc2ccccc2)[nH]1)c1ccccc1](/scaffold/GSQZTFOTNOERRU-UHFFFAOYSA-N/structure.svg)
O=C(NCc1nnc(SCc2ccccc2)[nH]1)c1ccccc19 chemicals
O=C(CN1C(=O)NC(CCc2ccccc2)C1=O)Nc1ccccc17 chemicals
O=C(Nc1ccccc1)Nc1nnc(COc2ccccc2)s17 chemicals
O=C1CC(NCCc2ccccc2)C(=O)N1CCc1ccccc17 chemicals
O=C(NN1C(=O)C(=CC=Cc2ccccc2)SC1=S)c1ccccc14 chemicals
O=C(CSc1nnc(SCc2ccccc2)s1)c1ccccc14 chemicals![Scaffold O=C(CSc1nnc(CSc2ccccc2)[nH]1)c1ccccc1](/scaffold/VDKIURXEZKFZCE-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(CSc2ccccc2)[nH]1)c1ccccc14 chemicals
O=C(Nc1ccccc1)Nc1cnc(NS(=O)(=O)c2ccccc2)s13 chemicals![Scaffold O=C(CSc1nnc(COc2ccccc2)[nH]1)c1ccccc1](/scaffold/DOPWGQFXPSYITK-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(COc2ccccc2)[nH]1)c1ccccc13 chemicals
O=C(NN1CC(C(=O)OCc2ccccc2)CC1=O)c1ccccc13 chemicals
O=C(Nc1nnc(SCC(=O)N2CCOCC2)s1)c1ccccc13 chemicals![Scaffold O=C(Cc1nnc(SCc2ccccc2)[nH]1)Nc1ccccc1](/scaffold/KKFYNHRCJVZOJH-UHFFFAOYSA-N/structure.svg)
O=C(Cc1nnc(SCc2ccccc2)[nH]1)Nc1ccccc12 chemicals