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Murcko scaffold

Ring system with 3 rings and 23 atoms

33 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
33
With full pages
3
Scaffold SMILES

O=C(CSc1nnc(COc2ccccc2)[nH]1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(COc2ccccc2)[nH]1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 33 of 33 chemicals

Ethanone, 2-((4-amino-5-((4-methylphenoxy)methyl)-4H-1,2,4-triazol-3-yl)thio)-1-phenyl- chemical structure, C18H18N4O2S, CAS 127399-29-5
Ethanone, 2-((4-amino-5-((4-methylphenoxy)methyl)-4H-1,2,4-triazol-3-yl)thio)-1-phenyl-
CAS 127399-29-5C18H18N4O2S
2-({4-Allyl-5-[(4-bromophenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-1-(4-methoxyphenyl)ethanone chemical structure, C21H20BrN3O3S, CAS 307325-85-5
2-({4-Allyl-5-[(4-bromophenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-1-(4-methoxyphenyl)ethanone
CAS 307325-85-5C21H20BrN3O3S
1-(4-Bromophenyl)-2-[[5-(phenoxymethyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]ethanone chemical structure, C20H18BrN3O2S, CAS 352703-74-3
1-(4-Bromophenyl)-2-[[5-(phenoxymethyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]ethanone
CAS 352703-74-3C20H18BrN3O2S
2-({4-Methyl-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-1-phenylethanone chemical structure, C19H19N3O2S, CAS 666210-69-1
2-({4-Methyl-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-1-phenylethanone
CAS 666210-69-1C19H19N3O2S
1-(4-Bromophenyl)-2-({4-methyl-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)ethanone chemical structure, C19H18BrN3O2S, CAS 666210-70-4
1-(4-Bromophenyl)-2-({4-methyl-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)ethanone
CAS 666210-70-4C19H18BrN3O2S
1-(4-Chlorophenyl)-2-({4-methyl-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)ethanone chemical structure, C19H18ClN3O2S, CAS 666210-72-6
1-(4-Chlorophenyl)-2-({4-methyl-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)ethanone
CAS 666210-72-6C19H18ClN3O2S
1-(4-Bromophenyl)-2-[[4-ethyl-5-(phenoxymethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone chemical structure, C19H18BrN3O2S, CAS 665018-95-1
1-(4-Bromophenyl)-2-[[4-ethyl-5-(phenoxymethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone
CAS 665018-95-1C19H18BrN3O2S
1-(4-Bromophenyl)-2-{[4-methyl-5-(phenoxymethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}ethanone chemical structure, C18H16BrN3O2S, CAS 665018-96-2
1-(4-Bromophenyl)-2-{[4-methyl-5-(phenoxymethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}ethanone
CAS 665018-96-2C18H16BrN3O2S
1-(2,5-Dimethoxyphenyl)-2-({4-ethyl-5-[(3-methoxyphenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)ethan-1-one chemical structure, C22H25N3O5S, CAS 3855-79-6
1-(2,5-Dimethoxyphenyl)-2-({4-ethyl-5-[(3-methoxyphenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)ethan-1-one
CAS 3855-79-6C22H25N3O5S
1-(4-Methoxyphenyl)-2-[[5-(phenoxymethyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]ethanone chemical structure, C21H21N3O3S, CAS 352702-77-3
1-(4-Methoxyphenyl)-2-[[5-(phenoxymethyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]ethanone
CAS 352702-77-3C21H21N3O3S
1-(4-Bromophenyl)-2-[[4-ethyl-5-[(2-methylphenoxy)methyl]-1,2,4-triazol-3-yl]sulfanyl]ethanone chemical structure, C20H20BrN3O2S, CAS 767325-02-0
1-(4-Bromophenyl)-2-[[4-ethyl-5-[(2-methylphenoxy)methyl]-1,2,4-triazol-3-yl]sulfanyl]ethanone
CAS 767325-02-0C20H20BrN3O2S
2-[[5-[(2,6-Dimethylphenoxy)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-1-(3-nitrophenyl)ethanone chemical structure, C22H22N4O4S, CAS 767326-93-2
2-[[5-[(2,6-Dimethylphenoxy)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-1-(3-nitrophenyl)ethanone
CAS 767326-93-2C22H22N4O4S
2-[[5-[(2-Ethoxy-4-methylphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-1-(3-nitrophenyl)ethanone chemical structure, C21H22N4O5S, CAS 767326-99-8
2-[[5-[(2-Ethoxy-4-methylphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-1-(3-nitrophenyl)ethanone
CAS 767326-99-8C21H22N4O5S
2-[[4-Methyl-5-(phenoxymethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(3-nitrophenyl)ethanone chemical structure, C18H16N4O4S, CAS 767326-92-1
2-[[4-Methyl-5-(phenoxymethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(3-nitrophenyl)ethanone
CAS 767326-92-1C18H16N4O4S
2-[[5-[(2,6-Dimethylphenoxy)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone chemical structure, C22H25N3O3S, CAS 767326-38-5
2-[[5-[(2,6-Dimethylphenoxy)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone
CAS 767326-38-5C22H25N3O3S
2-[[5-[(2-Methoxyphenoxy)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone chemical structure, C22H23N3O4S, CAS 767326-60-3
2-[[5-[(2-Methoxyphenoxy)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone
CAS 767326-60-3C22H23N3O4S
1-(4-Bromophenyl)-2-[[5-[(2,6-dimethylphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]ethanone chemical structure, C20H20BrN3O2S, CAS 694507-70-5
1-(4-Bromophenyl)-2-[[5-[(2,6-dimethylphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]ethanone
CAS 694507-70-5C20H20BrN3O2S
2-[[4-Methyl-5-[(2-methylphenoxy)methyl]-1,2,4-triazol-3-yl]sulfanyl]-1-(4-nitrophenyl)ethanone chemical structure, C19H18N4O4S, CAS 694451-11-1
2-[[4-Methyl-5-[(2-methylphenoxy)methyl]-1,2,4-triazol-3-yl]sulfanyl]-1-(4-nitrophenyl)ethanone
CAS 694451-11-1C19H18N4O4S
2-({5-[(4-Chlorophenoxy)methyl]-4-(prop-2-en-1-yl)-4H-1,2,4-triazol-3-yl}sulfanyl)-1-phenylethanone chemical structure, C20H18ClN3O2S, CAS 745805-79-2
2-({5-[(4-Chlorophenoxy)methyl]-4-(prop-2-en-1-yl)-4H-1,2,4-triazol-3-yl}sulfanyl)-1-phenylethanone
CAS 745805-79-2C20H18ClN3O2S
1-(4-Bromophenyl)-2-[[5-[(2-chlorophenoxy)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]ethanone chemical structure, C19H17BrClN3O2S, CAS 694468-38-7
1-(4-Bromophenyl)-2-[[5-[(2-chlorophenoxy)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]ethanone
CAS 694468-38-7C19H17BrClN3O2S
1-(4-Bromophenyl)-2-[[5-[(2,6-dimethylphenoxy)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]ethanone chemical structure, C22H22BrN3O2S, CAS 708245-94-7
1-(4-Bromophenyl)-2-[[5-[(2,6-dimethylphenoxy)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]ethanone
CAS 708245-94-7C22H22BrN3O2S
1-(4-Bromophenyl)-2-[[5-[(2-ethoxy-4-methylphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]ethanone chemical structure, C21H22BrN3O3S, CAS 708995-61-3
1-(4-Bromophenyl)-2-[[5-[(2-ethoxy-4-methylphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]ethanone
CAS 708995-61-3C21H22BrN3O3S
2-[[5-[(2,6-Dimethylphenoxy)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone chemical structure, C21H23N3O2S, CAS 713498-59-0
2-[[5-[(2,6-Dimethylphenoxy)methyl]-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-1-phenylethanone
CAS 713498-59-0C21H23N3O2S
2-[[5-[(2-Ethoxy-4-methylphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone chemical structure, C22H25N3O4S, CAS 767326-58-9
2-[[5-[(2-Ethoxy-4-methylphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone
CAS 767326-58-9C22H25N3O4S