Murcko scaffold
Ring system with 3 rings and 23 atoms
116 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 23
- Chemicals
- 116
- With full pages
- 7
Scaffold SMILES
O=C(Nc1ccccc1)Nc1nnc(COc2ccccc2)s1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 116 chemicals
![N-{5-[(4-Fluorophenoxy)methyl]-1,3,4-thiadiazol-2-yl}-N'-phenylurea chemical structure, C16H13FN4O2S, CAS 5658-26-4](/s/FABUAUZTPIBDTG-UHFFFAOYSA-N.svg)
N-{5-[(4-Fluorophenoxy)methyl]-1,3,4-thiadiazol-2-yl}-N'-phenylurea
CAS 5658-26-4C16H13FN4O2S
![1-[5-[(2-Fluorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-phenylurea chemical structure, C16H13FN4O2S, CAS 497866-23-6](/s/MSOHUKLXDPFFLP-UHFFFAOYSA-N.svg)
1-[5-[(2-Fluorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-phenylurea
CAS 497866-23-6C16H13FN4O2S
1-(5-((2-Fluorophenoxy)methyl)-1,3,4-thiadiazol-2-yl)-3-(4-methoxyphenyl)urea
CAS 426242-91-3C17H15FN4O3S
![1-(4-Methoxyphenyl)-3-[5-[(2-prop-2-enylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]urea chemical structure, C20H20N4O3S, CAS 426249-00-5](/s/QNBTWXBMRDIGSR-UHFFFAOYSA-N.svg)
1-(4-Methoxyphenyl)-3-[5-[(2-prop-2-enylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]urea
CAS 426249-00-5C20H20N4O3S
![1-(4-Methoxyphenyl)-3-[5-[(4-methylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]urea chemical structure, C18H18N4O3S, CAS 426248-72-8](/s/UTBSANPZBWHQRE-UHFFFAOYSA-N.svg)
1-(4-Methoxyphenyl)-3-[5-[(4-methylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]urea
CAS 426248-72-8C18H18N4O3S
![1-(4-Methoxyphenyl)-3-[5-(phenoxymethyl)-1,3,4-thiadiazol-2-yl]urea chemical structure, C17H16N4O3S, CAS 328261-12-7](/s/IVYFEBZYGNNPLH-UHFFFAOYSA-N.svg)
1-(4-Methoxyphenyl)-3-[5-(phenoxymethyl)-1,3,4-thiadiazol-2-yl]urea
CAS 328261-12-7C17H16N4O3S
![1-[5-[(4-Ethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea chemical structure, C18H17FN4O2S, CAS 426251-59-4](/s/SMWTTZCBVGGWFR-UHFFFAOYSA-N.svg)
1-[5-[(4-Ethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea
CAS 426251-59-4C18H17FN4O2S
1-(5-((3,5-Dimethylphenoxy)methyl)-1,3,4-thiadiazol-2-yl)-3-(4-methoxyphenyl)urea
CAS 426252-62-2C19H20N4O3S
1-(4-Methoxyphenyl)-3-(5-((4-propylphenoxy)methyl)-1,3,4-thiadiazol-2-yl)urea
CAS 426235-25-8C20H22N4O3S
1-(5-((2,6-Dimethylphenoxy)methyl)-1,3,4-thiadiazol-2-yl)-3-(4-methoxyphenyl)urea
CAS 426236-09-1C19H20N4O3S
1-(5-((2,3-Dimethylphenoxy)methyl)-1,3,4-thiadiazol-2-yl)-3-(4-methoxyphenyl)urea
CAS 426236-69-3C19H20N4O3S
![1-{5-[(3,5-Dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea chemical structure, C19H20N4O2S, CAS 426237-05-0](/s/KGZQJZXTLJDQDO-UHFFFAOYSA-N.svg)
1-{5-[(3,5-Dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea
CAS 426237-05-0C19H20N4O2S
![1-{5-[(3,4-Dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-fluorophenyl)urea chemical structure, C18H17FN4O2S, CAS 426237-43-6](/s/BMEHYLLHCROGCW-UHFFFAOYSA-N.svg)
1-{5-[(3,4-Dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-fluorophenyl)urea
CAS 426237-43-6C18H17FN4O2S
![1-{5-[(4-Bromophenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-fluorophenyl)urea chemical structure, C16H12BrFN4O2S, CAS 426237-49-2](/s/RZWUHZJKSPGVLD-UHFFFAOYSA-N.svg)
1-{5-[(4-Bromophenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-fluorophenyl)urea
CAS 426237-49-2C16H12BrFN4O2S
![1-[5-[(4-Bromophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-ethoxyphenyl)urea chemical structure, C18H17BrN4O3S, CAS 426238-61-1](/s/YHWKMKALUYVBMP-UHFFFAOYSA-N.svg)
1-[5-[(4-Bromophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-ethoxyphenyl)urea
CAS 426238-61-1C18H17BrN4O3S
![1-[5-[(2,3-Dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-ethoxyphenyl)urea chemical structure, C20H22N4O3S, CAS 426238-85-9](/s/JHIJTDKSEQSKCT-UHFFFAOYSA-N.svg)
1-[5-[(2,3-Dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-ethoxyphenyl)urea
CAS 426238-85-9C20H22N4O3S
![1-(4-Ethoxyphenyl)-3-[5-[(4-fluorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]urea chemical structure, C18H17FN4O3S, CAS 426239-82-9](/s/UFCCMTPTPZCPAE-UHFFFAOYSA-N.svg)
1-(4-Ethoxyphenyl)-3-[5-[(4-fluorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]urea
CAS 426239-82-9C18H17FN4O3S
![1-[5-[(4-Chloro-3-methylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-ethoxyphenyl)urea chemical structure, C19H19ClN4O3S, CAS 426241-72-7](/s/XKVQJSVWMNWBPW-UHFFFAOYSA-N.svg)
1-[5-[(4-Chloro-3-methylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-ethoxyphenyl)urea
CAS 426241-72-7C19H19ClN4O3S
![1-[5-[(2,5-Dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea chemical structure, C18H17FN4O2S, CAS 426242-12-8](/s/DFXHVCZOLBHUSQ-UHFFFAOYSA-N.svg)
1-[5-[(2,5-Dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea
CAS 426242-12-8C18H17FN4O2S
![1-[5-[(2-Fluorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea chemical structure, C17H15FN4O2S, CAS 426242-72-0](/s/IETGUGFIVOIZRQ-UHFFFAOYSA-N.svg)
1-[5-[(2-Fluorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea
CAS 426242-72-0C17H15FN4O2S
![1-(4-Fluorophenyl)-3-{5-[(4-nitrophenoxy)methyl]-1,3,4-thiadiazol-2-yl}urea chemical structure, C16H12FN5O4S, CAS 426243-00-7](/s/RJNKQACFTBAESF-UHFFFAOYSA-N.svg)
1-(4-Fluorophenyl)-3-{5-[(4-nitrophenoxy)methyl]-1,3,4-thiadiazol-2-yl}urea
CAS 426243-00-7C16H12FN5O4S
![1-(4-Ethoxyphenyl)-3-[5-[(2-prop-2-enylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]urea chemical structure, C21H22N4O3S, CAS 426244-06-6](/s/VPAJEIAJUTWOMS-UHFFFAOYSA-N.svg)
1-(4-Ethoxyphenyl)-3-[5-[(2-prop-2-enylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]urea
CAS 426244-06-6C21H22N4O3S
![1-{5-[(4-Chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea chemical structure, C17H15ClN4O2S, CAS 426244-14-6](/s/SGQAJCXIEVSIPK-UHFFFAOYSA-N.svg)
1-{5-[(4-Chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea
CAS 426244-14-6C17H15ClN4O2S
![1-{5-[(4-Chloro-2-methylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea chemical structure, C18H17ClN4O2S, CAS 426245-00-3](/s/KNVMTYVCIUBBFO-UHFFFAOYSA-N.svg)
1-{5-[(4-Chloro-2-methylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea
CAS 426245-00-3C18H17ClN4O2S
- 1-(4-Ethoxyphenyl)-3-[5-[(4-ethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]urea426245-88-7C20H22N4O3S
- 1-{5-[(4-Chloro-2-methylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-chlorophenyl)urea426246-21-1C17H14Cl2N4O2S
- 1-(5-((4-Chlorophenoxy)methyl)-1,3,4-thiadiazol-2-yl)-3-(4-methoxyphenyl)urea426249-30-1C17H15ClN4O3S
- 1-{5-[(4-Ethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea426250-00-2C19H20N4O2S
- 1-{5-[(3,5-Dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-fluorophenyl)urea426250-18-2C18H17FN4O2S
- 1-[5-[(4-Chloro-2-methylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-ethoxyphenyl)urea426250-95-5C19H19ClN4O3S
- 1-[5-[(3,4-Dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-ethoxyphenyl)urea426234-86-8C20H22N4O3S
- 1-[5-[(2,3-Dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea426236-64-8C18H17FN4O2S
- 1-[5-[(3,4-Dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-methoxyphenyl)urea426237-84-5C19H20N4O3S
- 1-(4-Methylphenyl)-3-(5-{[2-(prop-2-en-1-yl)phenoxy]methyl}-1,3,4-thiadiazol-2-yl)urea426238-45-1C20H20N4O2S
- 1-[5-[(4-Chloro-3-methylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-methoxyphenyl)urea426239-11-4C18H17ClN4O3S
- 1-{5-[(4-Chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-fluorophenyl)urea426239-49-8C16H12ClFN4O2S
- 1-(3,4-Dimethylphenyl)-3-[5-[(4-ethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]urea429623-82-5C20H22N4O2S
- 1-[5-[(4-Bromophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(3,4-dimethylphenyl)urea429624-87-3C18H17BrN4O2S
- 1-(3,4-Dimethylphenyl)-3-{5-[(4-methylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}urea429626-28-8C19H20N4O2S
- 1-[5-[(2,6-Dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(3,4-dimethylphenyl)urea429626-30-2C20H22N4O2S
- 1-{5-[(2-Chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(3,4-dimethylphenyl)urea429626-41-5C18H17ClN4O2S
- 1-{5-[(4-Chloro-3-methylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(3,4-dimethylphenyl)urea429626-44-8C19H19ClN4O2S
- 1-(3,4-Dimethylphenyl)-3-{5-[(4-nitrophenoxy)methyl]-1,3,4-thiadiazol-2-yl}urea429626-49-3C18H17N5O4S
- 1-(3,4-Dimethylphenyl)-3-(5-{[2-(prop-2-en-1-yl)phenoxy]methyl}-1,3,4-thiadiazol-2-yl)urea429626-97-1C21H22N4O2S
- 1-[5-[(4-Chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-3-(3,4-dimethylphenyl)urea429628-15-9C18H17ClN4O2S
- 1-(3,4-Dimethylphenyl)-3-[5-[(4-methoxyphenoxy)methyl]-1,3,4-thiadiazol-2-yl]urea429628-65-9C19H20N4O3S
- 1-{5-[(3,5-Dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(3,4-dimethylphenyl)urea429631-51-6C20H22N4O2S
- 1-{5-[(4-tert-Butylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(3,4-dimethylphenyl)urea429632-21-3C22H26N4O2S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(NCc1nnc(SCc2ccccc2)[nH]1)c1ccccc1](/scaffold/GSQZTFOTNOERRU-UHFFFAOYSA-N/structure.svg)
O=C(NCc1nnc(SCc2ccccc2)[nH]1)c1ccccc19 chemicals
O=C(CN1C(=O)NC(CCc2ccccc2)C1=O)Nc1ccccc17 chemicals
O=C1CC(NCCc2ccccc2)C(=O)N1CCc1ccccc17 chemicals
O=C(NN1C(=O)C(=CC=Cc2ccccc2)SC1=S)c1ccccc14 chemicals
O=C(CSc1nnc(SCc2ccccc2)s1)c1ccccc14 chemicals![Scaffold O=C(CSc1nnc(CSc2ccccc2)[nH]1)c1ccccc1](/scaffold/VDKIURXEZKFZCE-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(CSc2ccccc2)[nH]1)c1ccccc14 chemicals
O=C(Nc1ccccc1)Nc1cnc(NS(=O)(=O)c2ccccc2)s13 chemicals![Scaffold O=C(CSc1nnc(COc2ccccc2)[nH]1)c1ccccc1](/scaffold/DOPWGQFXPSYITK-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(COc2ccccc2)[nH]1)c1ccccc13 chemicals
O=C(NN1CC(C(=O)OCc2ccccc2)CC1=O)c1ccccc13 chemicals
O=C(Cn1cc(C(=O)Nc2ccccc2)nn1)Nc1ccccc13 chemicals
O=C(Nc1nnc(SCC(=O)N2CCOCC2)s1)c1ccccc13 chemicals![Scaffold O=C(Cc1nnc(SCc2ccccc2)[nH]1)Nc1ccccc1](/scaffold/KKFYNHRCJVZOJH-UHFFFAOYSA-N/structure.svg)
O=C(Cc1nnc(SCc2ccccc2)[nH]1)Nc1ccccc12 chemicals