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Murcko scaffold

Ring system with 3 rings and 18 atoms

73 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
73
With full pages
14
Scaffold SMILES

O=c1cc(CN2CCNCC2)c2ccccc2o1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1cc(CN2CCNCC2)c2ccccc2o1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 73 of 73 chemicals

6-Ethyl-4-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-2H-chromen-2-one chemical structure, C18H24N2O3, CAS 899405-85-7
6-Ethyl-4-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-2H-chromen-2-one
CAS 899405-85-7C18H24N2O3
Ethyl 4-[(7,8-dihydroxy-2-oxo-2H-chromen-4-yl)methyl]piperazine-1-carboxylate chemical structure, C17H20N2O6, CAS 859858-05-2
Ethyl 4-[(7,8-dihydroxy-2-oxo-2H-chromen-4-yl)methyl]piperazine-1-carboxylate
CAS 859858-05-2C17H20N2O6
Ethyl 4-[(7-hydroxy-8-methyl-2-oxo-2H-chromen-4-yl)methyl]piperazine-1-carboxylate chemical structure, C18H22N2O5, CAS 859128-46-4
Ethyl 4-[(7-hydroxy-8-methyl-2-oxo-2H-chromen-4-yl)methyl]piperazine-1-carboxylate
CAS 859128-46-4C18H22N2O5
Ethyl 4-[(6-ethyl-7-hydroxy-2-oxochromen-4-yl)methyl]piperazine-1-carboxylate chemical structure, C19H24N2O5, CAS 896821-93-5
Ethyl 4-[(6-ethyl-7-hydroxy-2-oxochromen-4-yl)methyl]piperazine-1-carboxylate
CAS 896821-93-5C19H24N2O5
7-Hydroxy-4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-8-methyl-2H-chromen-2-one chemical structure, C17H22N2O4, CAS 896825-61-9
7-Hydroxy-4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-8-methyl-2H-chromen-2-one
CAS 896825-61-9C17H22N2O4
6-Chloro-7-hydroxy-4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-2H-chromen-2-one chemical structure, C16H19ClN2O4, CAS 896836-47-8
6-Chloro-7-hydroxy-4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-2H-chromen-2-one
CAS 896836-47-8C16H19ClN2O4
7-Hydroxy-8-methyl-4-[(4-methylpiperazin-1-yl)methyl]-2H-chromen-2-one chemical structure, C16H20N2O3, CAS 899397-66-1
7-Hydroxy-8-methyl-4-[(4-methylpiperazin-1-yl)methyl]-2H-chromen-2-one
CAS 899397-66-1C16H20N2O3
4-((4-Ethylpiperazin-1-yl)methyl)-7-hydroxy-8-methyl-2H-chromen-2-one chemical structure, C17H22N2O3, CAS 896599-00-1
4-((4-Ethylpiperazin-1-yl)methyl)-7-hydroxy-8-methyl-2H-chromen-2-one
CAS 896599-00-1C17H22N2O3
Ethyl 4-[(6-chloro-7-hydroxy-2-oxochromen-4-yl)methyl]piperazine-1-carboxylate chemical structure, C17H19ClN2O5, CAS 877800-39-0
Ethyl 4-[(6-chloro-7-hydroxy-2-oxochromen-4-yl)methyl]piperazine-1-carboxylate
CAS 877800-39-0C17H19ClN2O5
5-Hydroxy-4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-7-methyl-2H-chromen-2-one chemical structure, C17H22N2O4, CAS 859667-33-7
5-Hydroxy-4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-7-methyl-2H-chromen-2-one
CAS 859667-33-7C17H22N2O4
6-Chloro-4-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-2H-chromen-2-one chemical structure, C16H19ClN2O3, CAS 903183-83-5
6-Chloro-4-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-2H-chromen-2-one
CAS 903183-83-5C16H19ClN2O3
6-Isopropyl-4-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one chemical structure, C18H24N2O2, CAS 903856-37-1
6-Isopropyl-4-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one
CAS 903856-37-1C18H24N2O2
6-Hydroxy-4-[(4-methylpiperazin-1-yl)methyl]chromen-2-one chemical structure, C15H18N2O3, CAS 903193-44-2
6-Hydroxy-4-[(4-methylpiperazin-1-yl)methyl]chromen-2-one
CAS 903193-44-2C15H18N2O3
6-Hydroxy-4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-2H-chromen-2-one chemical structure, C16H20N2O4, CAS 919727-42-7
6-Hydroxy-4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-2H-chromen-2-one
CAS 919727-42-7C16H20N2O4
7-Methoxy-4-(piperazin-1-ylmethyl)-2H-chromen-2-one chemical structure, C15H18N2O3, CAS 937603-48-0
7-Methoxy-4-(piperazin-1-ylmethyl)-2H-chromen-2-one
CAS 937603-48-0C15H18N2O3
8-Methyl-4-(1-piperazinylmethyl)-2H-1-benzopyran-2-one chemical structure, C15H18N2O2, CAS 937603-50-4
8-Methyl-4-(1-piperazinylmethyl)-2H-1-benzopyran-2-one
CAS 937603-50-4C15H18N2O2
5,7-Dimethyl-4-(piperazin-1-ylmethyl)-2H-chromen-2-one chemical structure, C16H20N2O2, CAS 1279219-34-9
5,7-Dimethyl-4-(piperazin-1-ylmethyl)-2H-chromen-2-one
CAS 1279219-34-9C16H20N2O2
7,8-Dimethyl-4-(piperazin-1-ylmethyl)-2H-chromen-2-one chemical structure, C16H20N2O2, CAS 1279219-15-6
7,8-Dimethyl-4-(piperazin-1-ylmethyl)-2H-chromen-2-one
CAS 1279219-15-6C16H20N2O2
4-((4-(2-Hydroxyethyl)piperazin-1-yl)methyl)-6-isopropyl-2H-chromen-2-one dihydrochloride chemical structure, C19H28Cl2N2O3, CAS 1177723-39-5
4-((4-(2-Hydroxyethyl)piperazin-1-yl)methyl)-6-isopropyl-2H-chromen-2-one dihydrochloride
CAS 1177723-39-5C19H28Cl2N2O3
4-((4-Ethylpiperazin-1-yl)methyl)-6-isopropyl-2H-chromen-2-one dihydrochloride chemical structure, C19H28Cl2N2O2, CAS 1177927-52-4
4-((4-Ethylpiperazin-1-yl)methyl)-6-isopropyl-2H-chromen-2-one dihydrochloride
CAS 1177927-52-4C19H28Cl2N2O2
6-Chloro-7-hydroxy-4-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one dihydrochloride chemical structure, C15H19Cl3N2O3, CAS 1177634-15-9
6-Chloro-7-hydroxy-4-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one dihydrochloride
CAS 1177634-15-9C15H19Cl3N2O3
6-Chloro-5,7-dimethyl-4-[(4-methylpiperazin-1-yl)methyl]-2H-chromen-2-one hydrochloride chemical structure, C17H22Cl2N2O2, CAS 1177922-21-2
6-Chloro-5,7-dimethyl-4-[(4-methylpiperazin-1-yl)methyl]-2H-chromen-2-one hydrochloride
CAS 1177922-21-2C17H22Cl2N2O2
tert-Butyl 4-[(7-methyl-2-oxochromen-4-yl)methyl]piperazinecarboxylate chemical structure, C20H26N2O4, CAS 933885-46-2
tert-Butyl 4-[(7-methyl-2-oxochromen-4-yl)methyl]piperazinecarboxylate
CAS 933885-46-2C20H26N2O4
7,8-Dimethyl-4-(piperazin-1-ylmethyl)-2H-chromen-2-one dihydrochloride chemical structure, C16H22Cl2N2O2
7,8-Dimethyl-4-(piperazin-1-ylmethyl)-2H-chromen-2-one dihydrochloride
C16H22Cl2N2O2