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Murcko scaffold

Ring system with 3 rings and 24 atoms

40 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
40
With full pages
8
Scaffold SMILES

O=C(Nc1ccccc1)N1CCN(S(=O)(=O)c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)N1CCN(S(=O)(=O)c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 40 of 40 chemicals

4-(Mesitylsulfonyl)-N-methyl-N-(4-methylphenyl)-1-piperazinecarboxamide chemical structure, C22H29N3O3S, CAS 701925-51-1
4-(Mesitylsulfonyl)-N-methyl-N-(4-methylphenyl)-1-piperazinecarboxamide
CAS 701925-51-1C22H29N3O3S
4-[(3,4-Dimethylphenyl)sulfonyl]-N-methyl-N-(4-methylphenyl)-1-piperazinecarboxamide chemical structure, C21H27N3O3S, CAS 708240-10-2
4-[(3,4-Dimethylphenyl)sulfonyl]-N-methyl-N-(4-methylphenyl)-1-piperazinecarboxamide
CAS 708240-10-2C21H27N3O3S
4-(Benzenesulfonyl)-N-methyl-N-phenyl-1-piperazinecarboxamide chemical structure, C18H21N3O3S, CAS 526190-60-3
4-(Benzenesulfonyl)-N-methyl-N-phenyl-1-piperazinecarboxamide
CAS 526190-60-3C18H21N3O3S
N-Methyl-N-phenyl-4-tosylpiperazine-1-carboxamide chemical structure, C19H23N3O3S, CAS 526190-61-4
N-Methyl-N-phenyl-4-tosylpiperazine-1-carboxamide
CAS 526190-61-4C19H23N3O3S
N-(3-Chloro-4-fluorophenyl)-4-(4-nitrophenyl)sulfonylpiperazine-1-carboxamide chemical structure, C17H16ClFN4O5S, CAS 774196-08-6
N-(3-Chloro-4-fluorophenyl)-4-(4-nitrophenyl)sulfonylpiperazine-1-carboxamide
CAS 774196-08-6C17H16ClFN4O5S
4-(2,5-Dichlorophenyl)sulfonyl-N-phenylpiperazine-1-carboxamide chemical structure, C17H17Cl2N3O3S, CAS 774195-93-6
4-(2,5-Dichlorophenyl)sulfonyl-N-phenylpiperazine-1-carboxamide
CAS 774195-93-6C17H17Cl2N3O3S
N-(4-Bromo-2-chlorophenyl)-4-(4-chlorophenyl)sulfonylpiperazine-1-carboxamide chemical structure, C17H16BrCl2N3O3S, CAS 701947-09-3
N-(4-Bromo-2-chlorophenyl)-4-(4-chlorophenyl)sulfonylpiperazine-1-carboxamide
CAS 701947-09-3C17H16BrCl2N3O3S
N-Methyl-N-(4-methylphenyl)-4-(3-nitrophenyl)sulfonylpiperazine-1-carboxamide chemical structure, C19H22N4O5S, CAS 700860-19-1
N-Methyl-N-(4-methylphenyl)-4-(3-nitrophenyl)sulfonylpiperazine-1-carboxamide
CAS 700860-19-1C19H22N4O5S
4-(4-Chlorophenyl)sulfonyl-N-(4-nitrophenyl)piperazine-1-carboxamide chemical structure, C17H17ClN4O5S, CAS 706773-19-5
4-(4-Chlorophenyl)sulfonyl-N-(4-nitrophenyl)piperazine-1-carboxamide
CAS 706773-19-5C17H17ClN4O5S
N-(2,4-Dimethoxyphenyl)-4-(3,4-dimethylphenyl)sulfonylpiperazine-1-carboxamide chemical structure, C21H27N3O5S, CAS 830339-59-8
N-(2,4-Dimethoxyphenyl)-4-(3,4-dimethylphenyl)sulfonylpiperazine-1-carboxamide
CAS 830339-59-8C21H27N3O5S
N-Methyl-4-(4-methylbenzenesulfonyl)-N-(4-methylphenyl)piperazine-1-carboxamide chemical structure, C20H25N3O3S, CAS 889808-87-1
N-Methyl-4-(4-methylbenzenesulfonyl)-N-(4-methylphenyl)piperazine-1-carboxamide
CAS 889808-87-1C20H25N3O3S
4-(4-Methoxyphenyl)sulfonyl-N-(2-methylphenyl)piperazine-1-carboxamide chemical structure, C19H23N3O4S, CAS 893342-47-7
4-(4-Methoxyphenyl)sulfonyl-N-(2-methylphenyl)piperazine-1-carboxamide
CAS 893342-47-7C19H23N3O4S
N-(3-Methoxyphenyl)-4-(4-methoxyphenyl)sulfonylpiperazine-1-carboxamide chemical structure, C19H23N3O5S, CAS 891171-20-3
N-(3-Methoxyphenyl)-4-(4-methoxyphenyl)sulfonylpiperazine-1-carboxamide
CAS 891171-20-3C19H23N3O5S
Ethyl 4-{[4-(phenylsulfonyl)piperazinyl]carbonylamino}benzoate chemical structure, C20H23N3O5S, CAS 888191-90-0
Ethyl 4-{[4-(phenylsulfonyl)piperazinyl]carbonylamino}benzoate
CAS 888191-90-0C20H23N3O5S
4-(Benzenesulfonyl)-N-(2-methylphenyl)piperazine-1-carboxamide chemical structure, C18H21N3O3S, CAS 893189-57-6
4-(Benzenesulfonyl)-N-(2-methylphenyl)piperazine-1-carboxamide
CAS 893189-57-6C18H21N3O3S
4-(Benzenesulfonyl)-N-(3-chlorophenyl)piperazine-1-carboxamide chemical structure, C17H18ClN3O3S, CAS 889343-46-8
4-(Benzenesulfonyl)-N-(3-chlorophenyl)piperazine-1-carboxamide
CAS 889343-46-8C17H18ClN3O3S
N-(2-Ethylphenyl)-4-(4-methoxyphenyl)sulfonylpiperazine-1-carboxamide chemical structure, C20H25N3O4S, CAS 891175-82-9
N-(2-Ethylphenyl)-4-(4-methoxyphenyl)sulfonylpiperazine-1-carboxamide
CAS 891175-82-9C20H25N3O4S
4-(Benzenesulfonyl)-N-(4-methoxyphenyl)piperazine-1-carboxamide chemical structure, C18H21N3O4S, CAS 903219-36-3
4-(Benzenesulfonyl)-N-(4-methoxyphenyl)piperazine-1-carboxamide
CAS 903219-36-3C18H21N3O4S
N-(3,5-Dimethylphenyl)-4-(4-fluorophenyl)sulfonylpiperazine-1-carboxamide chemical structure, C19H22FN3O3S, CAS 890947-98-5
N-(3,5-Dimethylphenyl)-4-(4-fluorophenyl)sulfonylpiperazine-1-carboxamide
CAS 890947-98-5C19H22FN3O3S
4-(Benzenesulfonyl)-N-(4-propan-2-ylphenyl)piperazine-1-carboxamide chemical structure, C20H25N3O3S, CAS 897537-44-9
4-(Benzenesulfonyl)-N-(4-propan-2-ylphenyl)piperazine-1-carboxamide
CAS 897537-44-9C20H25N3O3S
4-(Benzenesulfonyl)-N-(4-bromophenyl)piperazine-1-carboxamide chemical structure, C17H18BrN3O3S, CAS 895393-46-1
4-(Benzenesulfonyl)-N-(4-bromophenyl)piperazine-1-carboxamide
CAS 895393-46-1C17H18BrN3O3S
4-(Benzenesulfonyl)-N-(4-methylphenyl)piperazine-1-carboxamide chemical structure, C18H21N3O3S, CAS 893189-49-6
4-(Benzenesulfonyl)-N-(4-methylphenyl)piperazine-1-carboxamide
CAS 893189-49-6C18H21N3O3S
4-(4-Fluorophenyl)sulfonyl-N-phenylpiperazine-1-carboxamide chemical structure, C17H18FN3O3S, CAS 893166-00-2
4-(4-Fluorophenyl)sulfonyl-N-phenylpiperazine-1-carboxamide
CAS 893166-00-2C17H18FN3O3S
4-(4-Fluorophenyl)sulfonyl-N-(3-methylphenyl)piperazine-1-carboxamide chemical structure, C18H20FN3O3S, CAS 902632-82-0
4-(4-Fluorophenyl)sulfonyl-N-(3-methylphenyl)piperazine-1-carboxamide
CAS 902632-82-0C18H20FN3O3S