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Murcko scaffold

4,6-Diphenyl-2-pyridone scaffold

62 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
62
With full pages
6
Scaffold SMILES

O=c1cc(-c2ccccc2)cc(-c2ccccc2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4,6-Diphenyl-2-pyridone page
Murcko scaffold O=c1cc(-c2ccccc2)cc(-c2ccccc2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 62 chemicals

4-(4-Chlorophenyl)-3-(dimethylamino)-6-phenyl-2-pyridinol chemical structure, C19H17ClN2O, CAS 16607-19-5
4-(4-Chlorophenyl)-3-(dimethylamino)-6-phenyl-2-pyridinol
CAS 16607-19-5C19H17ClN2O
3-(Dimethylamino)-4-(4-methoxyphenyl)-6-phenyl-2-pyridinol chemical structure, C20H20N2O2, CAS 16607-18-4
3-(Dimethylamino)-4-(4-methoxyphenyl)-6-phenyl-2-pyridinol
CAS 16607-18-4C20H20N2O2
3-(Dimethylamino)-4,6-diphenyl-2-pyridinol chemical structure, C19H18N2O, CAS 16607-58-2
3-(Dimethylamino)-4,6-diphenyl-2-pyridinol
CAS 16607-58-2C19H18N2O
4-(4-Methoxyphenyl)-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile chemical structure, C19H14N2O2, CAS 38468-90-5
4-(4-Methoxyphenyl)-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile
CAS 38468-90-5C19H14N2O2
1,2-Dihydro-2-oxo-4,6-diphenyl-3-pyridinecarbonitrile chemical structure, C18H12N2O, CAS 16232-42-1
1,2-Dihydro-2-oxo-4,6-diphenyl-3-pyridinecarbonitrile
CAS 16232-42-1C18H12N2O
2-Oxo-4-phenyl-6-(P-tolyl)-1,2-dihydropyridine-3-carbonitrile chemical structure, C19H14N2O, CAS 38468-92-7
2-Oxo-4-phenyl-6-(P-tolyl)-1,2-dihydropyridine-3-carbonitrile
CAS 38468-92-7C19H14N2O
2-Hydroxy-6-(4-methoxyphenyl)-4-phenylnicotinonitrile chemical structure, C19H14N2O2, CAS 80306-65-6
2-Hydroxy-6-(4-methoxyphenyl)-4-phenylnicotinonitrile
CAS 80306-65-6C19H14N2O2
2(1H)-Pyridinone, 4-(4-chlorophenyl)-6-phenyl- chemical structure, C17H12ClNO, CAS 143968-99-4
2(1H)-Pyridinone, 4-(4-chlorophenyl)-6-phenyl-
CAS 143968-99-4C17H12ClNO
RefChem:388711 chemical structure, C18H11ClN2O, CAS 65429-76-7
RefChem:388711
CAS 65429-76-7C18H11ClN2O
6-(4-Fluorophenyl)-1,2-dihydro-2-oxo-4-phenyl-3-pyridinecarbonitrile chemical structure, C18H11FN2O, CAS 106020-49-9
6-(4-Fluorophenyl)-1,2-dihydro-2-oxo-4-phenyl-3-pyridinecarbonitrile
CAS 106020-49-9C18H11FN2O
6-(5-Bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile chemical structure, C18H11BrN2O2, CAS 491871-58-0
6-(5-Bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile
CAS 491871-58-0C18H11BrN2O2
6-(4-Chlorophenyl)-4-(2,4-dichlorophenyl)-2-hydroxynicotinonitrile chemical structure, C18H9Cl3N2O, CAS 341964-40-7
6-(4-Chlorophenyl)-4-(2,4-dichlorophenyl)-2-hydroxynicotinonitrile
CAS 341964-40-7C18H9Cl3N2O
4-(2,4-Dichlorophenyl)-2-hydroxy-6-(4-methylphenyl)nicotinonitrile chemical structure, C19H12Cl2N2O, CAS 341964-42-9
4-(2,4-Dichlorophenyl)-2-hydroxy-6-(4-methylphenyl)nicotinonitrile
CAS 341964-42-9C19H12Cl2N2O
6-(2-Chlorophenyl)-2-hydroxy-4-(4-methylphenyl)nicotinonitrile chemical structure, C19H13ClN2O, CAS 341964-46-3
6-(2-Chlorophenyl)-2-hydroxy-4-(4-methylphenyl)nicotinonitrile
CAS 341964-46-3C19H13ClN2O
6-(3,4-Dichlorophenyl)-4-(4-methoxyphenyl)-2-oxo-1H-pyridine-3-carbonitrile chemical structure, C19H12Cl2N2O2, CAS 79325-10-3
6-(3,4-Dichlorophenyl)-4-(4-methoxyphenyl)-2-oxo-1H-pyridine-3-carbonitrile
CAS 79325-10-3C19H12Cl2N2O2
4-(4-Chlorophenyl)-6-(4-fluorophenyl)-2-oxo-1H-pyridine-3-carbonitrile chemical structure, C18H10ClFN2O, CAS 866143-57-9
4-(4-Chlorophenyl)-6-(4-fluorophenyl)-2-oxo-1H-pyridine-3-carbonitrile
CAS 866143-57-9C18H10ClFN2O
6-(3-Bromophenyl)-4-(4-chlorophenyl)-2-hydroxynicotinonitrile chemical structure, C18H10BrClN2O, CAS 478261-45-9
6-(3-Bromophenyl)-4-(4-chlorophenyl)-2-hydroxynicotinonitrile
CAS 478261-45-9C18H10BrClN2O
6-(4-Bromophenyl)-4-(4-chlorophenyl)-2-oxo-1H-pyridine-3-carbonitrile chemical structure, C18H10BrClN2O, CAS 122652-22-6
6-(4-Bromophenyl)-4-(4-chlorophenyl)-2-oxo-1H-pyridine-3-carbonitrile
CAS 122652-22-6C18H10BrClN2O
4-(4-Chlorophenyl)-2-hydroxy-6-[3-(trifluoromethyl)phenyl]nicotinonitrile chemical structure, C19H10ClF3N2O, CAS 478261-46-0
4-(4-Chlorophenyl)-2-hydroxy-6-[3-(trifluoromethyl)phenyl]nicotinonitrile
CAS 478261-46-0C19H10ClF3N2O
4-(4-Chlorophenyl)-2-hydroxy-6-[4-(trifluoromethyl)phenyl]nicotinonitrile chemical structure, C19H10ClF3N2O, CAS 478261-47-1
4-(4-Chlorophenyl)-2-hydroxy-6-[4-(trifluoromethyl)phenyl]nicotinonitrile
CAS 478261-47-1C19H10ClF3N2O
6-(4-Fluorophenyl)-2-hydroxy-4-[2-(trifluoromethyl)phenyl]nicotinonitrile chemical structure, C19H10F4N2O, CAS 478261-49-3
6-(4-Fluorophenyl)-2-hydroxy-4-[2-(trifluoromethyl)phenyl]nicotinonitrile
CAS 478261-49-3C19H10F4N2O
4,6-Bis(4-chlorophenyl)-2-hydroxynicotinonitrile chemical structure, C18H10Cl2N2O, CAS 133707-66-1
4,6-Bis(4-chlorophenyl)-2-hydroxynicotinonitrile
CAS 133707-66-1C18H10Cl2N2O
6-(2-Chlorophenyl)-4-(4-chlorophenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C18H10Cl2N2O, CAS 866143-70-6
6-(2-Chlorophenyl)-4-(4-chlorophenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 866143-70-6C18H10Cl2N2O
6-(4-Bromophenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile chemical structure, C18H11BrN2O, CAS 51863-62-8
6-(4-Bromophenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile
CAS 51863-62-8C18H11BrN2O