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Murcko scaffold

Ring system with 3 rings and 19 atoms

71 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
71
With full pages
6
Scaffold SMILES

O=c1[nH]c2ccccc2nc1C=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]c2ccccc2nc1C=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 71 chemicals

7-Chloro-3-[2-(4-methoxy-phenyl)-2-oxo-ethylidene]-3,4-dihydro-1H-quinoxalin-2-one chemical structure, C17H13ClN2O3, CAS 907170-21-2
7-Chloro-3-[2-(4-methoxy-phenyl)-2-oxo-ethylidene]-3,4-dihydro-1H-quinoxalin-2-one
CAS 907170-21-2C17H13ClN2O3
3-Phenacylidene-7-chloro-1,2,3,4-tetrahydroquinoxaline-2-one chemical structure, C16H11ClN2O2, CAS 906439-35-8
3-Phenacylidene-7-chloro-1,2,3,4-tetrahydroquinoxaline-2-one
CAS 906439-35-8C16H11ClN2O2
3-[(Z)-4-Methoxyphenacylidene]-3,4-dihydroquinoxaline-2(1H)-one chemical structure, C17H14N2O3
3-[(Z)-4-Methoxyphenacylidene]-3,4-dihydroquinoxaline-2(1H)-one
C17H14N2O3
3-[2-Hydroxy-2-(3-nitrophenyl)ethenyl]-8-nitro-1H-quinoxalin-2-one chemical structure, C16H10N4O6
3-[2-Hydroxy-2-(3-nitrophenyl)ethenyl]-8-nitro-1H-quinoxalin-2-one
C16H10N4O6
3-(2-Phenylvinyl)-2(1H)-quinoxalinone chemical structure, C16H12N2O, CAS 6323-89-3
3-(2-Phenylvinyl)-2(1H)-quinoxalinone
CAS 6323-89-3C16H12N2O
3-(3-Nitrostyryl)quinoxalin-2(1H)-one chemical structure, C16H11N3O3, CAS 6323-88-2
3-(3-Nitrostyryl)quinoxalin-2(1H)-one
CAS 6323-88-2C16H11N3O3
3-[(E)-2-(4-Fluorophenyl)ethenyl]-1-methylquinoxalin-2-one chemical structure, C17H13FN2O, CAS 831186-91-5
3-[(E)-2-(4-Fluorophenyl)ethenyl]-1-methylquinoxalin-2-one
CAS 831186-91-5C17H13FN2O
3-[(E)-2-(3-Methoxyphenyl)ethenyl]-1-methylquinoxalin-2-one chemical structure, C18H16N2O2, CAS 831188-82-0
3-[(E)-2-(3-Methoxyphenyl)ethenyl]-1-methylquinoxalin-2-one
CAS 831188-82-0C18H16N2O2
(E)-3-(4-Ethoxystyryl)-1-methylquinoxalin-2(1H)-one chemical structure, C19H18N2O2, CAS 831206-02-1
(E)-3-(4-Ethoxystyryl)-1-methylquinoxalin-2(1H)-one
CAS 831206-02-1C19H18N2O2
(E)-3-(4-Ethylstyryl)-1-methylquinoxalin-2(1H)-one chemical structure, C19H18N2O, CAS 1351284-56-4
(E)-3-(4-Ethylstyryl)-1-methylquinoxalin-2(1H)-one
CAS 1351284-56-4C19H18N2O
(E)-3-(4-Chlorostyryl)-1-methylquinoxalin-2(1H)-one chemical structure, C17H13ClN2O, CAS 93585-06-9
(E)-3-(4-Chlorostyryl)-1-methylquinoxalin-2(1H)-one
CAS 93585-06-9C17H13ClN2O
(E)-3-(4-Methoxystyryl)-1-methylquinoxalin-2(1H)-one chemical structure, C18H16N2O2, CAS 93585-01-4
(E)-3-(4-Methoxystyryl)-1-methylquinoxalin-2(1H)-one
CAS 93585-01-4C18H16N2O2
(E)-1-Methyl-3-(4-methylstyryl)quinoxalin-2(1H)-one chemical structure, C18H16N2O, CAS 93585-02-5
(E)-1-Methyl-3-(4-methylstyryl)quinoxalin-2(1H)-one
CAS 93585-02-5C18H16N2O
(E)-1-Methyl-3-(3-methylstyryl)quinoxalin-2(1H)-one chemical structure, C18H16N2O, CAS 797782-02-6
(E)-1-Methyl-3-(3-methylstyryl)quinoxalin-2(1H)-one
CAS 797782-02-6C18H16N2O
(E)-3-(4-Isopropylstyryl)-1-methylquinoxalin-2(1H)-one chemical structure, C20H20N2O, CAS 867135-89-5
(E)-3-(4-Isopropylstyryl)-1-methylquinoxalin-2(1H)-one
CAS 867135-89-5C20H20N2O
(E)-3-(4-Ethylstyryl)quinoxalin-2(1H)-one chemical structure, C18H16N2O, CAS 868155-49-1
(E)-3-(4-Ethylstyryl)quinoxalin-2(1H)-one
CAS 868155-49-1C18H16N2O
3-[(E)-2-(2-Ethoxyphenyl)ethenyl]-1H-quinoxalin-2-one chemical structure, C18H16N2O2, CAS 868214-14-6
3-[(E)-2-(2-Ethoxyphenyl)ethenyl]-1H-quinoxalin-2-one
CAS 868214-14-6C18H16N2O2
(E)-3-(2,4-Dichlorostyryl)quinoxalin-2(1H)-one chemical structure, C16H10Cl2N2O, CAS 496845-76-2
(E)-3-(2,4-Dichlorostyryl)quinoxalin-2(1H)-one
CAS 496845-76-2C16H10Cl2N2O
7-Methyl-3-[(E)-2-(3-nitrophenyl)ethenyl]-1H-quinoxalin-2-one chemical structure, C17H13N3O3, CAS 6322-10-7
7-Methyl-3-[(E)-2-(3-nitrophenyl)ethenyl]-1H-quinoxalin-2-one
CAS 6322-10-7C17H13N3O3
7-Methyl-3-[(E)-2-phenylethenyl]-1H-quinoxalin-2-one chemical structure, C17H14N2O, CAS 6322-12-9
7-Methyl-3-[(E)-2-phenylethenyl]-1H-quinoxalin-2-one
CAS 6322-12-9C17H14N2O
3-[(Z)-3-Hydroxy-1-phenylprop-1-en-2-yl]-1H-quinoxalin-2-one chemical structure, C17H14N2O2, CAS 7478-53-7
3-[(Z)-3-Hydroxy-1-phenylprop-1-en-2-yl]-1H-quinoxalin-2-one
CAS 7478-53-7C17H14N2O2
3-[(E)-2-(2-Chlorophenyl)ethenyl]-7-methyl-1H-quinoxalin-2-one chemical structure, C17H13ClN2O, CAS 6322-09-4
3-[(E)-2-(2-Chlorophenyl)ethenyl]-7-methyl-1H-quinoxalin-2-one
CAS 6322-09-4C17H13ClN2O
(E)-1-Methyl-3-styrylquinoxalin-2(1H)-one chemical structure, C17H14N2O, CAS 93585-00-3
(E)-1-Methyl-3-styrylquinoxalin-2(1H)-one
CAS 93585-00-3C17H14N2O
3-[(E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1H-quinoxalin-2-one chemical structure, C18H16N2O3, CAS 868214-11-3
3-[(E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1H-quinoxalin-2-one
CAS 868214-11-3C18H16N2O3