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Murcko scaffold

Ring system with 4 rings and 22 atoms

66 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 22
Chemicals: 66
With full pages: 10

Scaffold SMILES

O=C(Nc1ccccc1)c1cc2cc3c(nc2s1)CCCC3

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1ccccc1)c1cc2cc3c(nc2s1)CCCC3

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 66 of 66 chemicals

3-Amino-6-ethyl-N-[2-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C21H20F3N3OS, CAS 445269-05-6

3-Amino-6-ethyl-N-[2-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 445269-05-6C₂₁H₂₀F₃N₃OS

3-Amino-6-ethyl-N-(4-methylphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C21H23N3OS, CAS 445269-01-2

3-Amino-6-ethyl-N-(4-methylphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 445269-01-2C₂₁H₂₃N₃OS

3-Amino-N-(3-ethoxyphenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C22H25N3O2S, CAS 625370-19-6

3-Amino-N-(3-ethoxyphenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 625370-19-6C₂₂H₂₅N₃O₂S

3-Amino-N-(3,4-difluorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H19F2N3OS, CAS 445269-03-4

3-Amino-N-(3,4-difluorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 445269-03-4C₂₀H₁₉F₂N₃OS

3-Amino-6-ethyl-N-(5-fluoro-2-methylphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C21H22FN3OS, CAS 625370-68-5

3-Amino-6-ethyl-N-(5-fluoro-2-methylphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 625370-68-5C₂₁H₂₂FN₃OS

3-Amino-6-ethyl-N-(3-ethylphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C22H25N3OS, CAS 625370-17-4

3-Amino-6-ethyl-N-(3-ethylphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 625370-17-4C₂₂H₂₅N₃OS

3-Amino-N-(3-chloro-2-methylphenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C21H22ClN3OS, CAS 625370-13-0

3-Amino-N-(3-chloro-2-methylphenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 625370-13-0C₂₁H₂₂ClN₃OS

3-Amino-6-ethyl-N-(4-methoxyphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C21H23N3O2S, CAS 445269-08-9

3-Amino-6-ethyl-N-(4-methoxyphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 445269-08-9C₂₁H₂₃N₃O₂S

3-Amino-N-(2,4-difluorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H19F2N3OS, CAS 445269-11-4

3-Amino-N-(2,4-difluorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 445269-11-4C₂₀H₁₉F₂N₃OS

3-Amino-N-(3-chloro-4-fluorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H19ClFN3OS, CAS 445269-00-1

3-Amino-N-(3-chloro-4-fluorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 445269-00-1C₂₀H₁₉ClFN₃OS

3-Amino-6-ethyl-N-(2-fluorophenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C21H19F4N3OS, CAS 939888-76-3

3-Amino-6-ethyl-N-(2-fluorophenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 939888-76-3C₂₁H₁₉F₄N₃OS

3-Amino-6-ethyl-N-(4-fluorophenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C21H19F4N3OS, CAS 939893-72-8

3-Amino-6-ethyl-N-(4-fluorophenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 939893-72-8C₂₁H₁₉F₄N₃OS

3-Amino-N-(3,4-difluorophenyl)-6-ethyl-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C21H18F5N3OS, CAS 939888-79-6

3-Amino-N-(3,4-difluorophenyl)-6-ethyl-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 939888-79-6C₂₁H₁₈F₅N₃OS

Ethyl 4-({[3-amino-6-ethyl-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinolin-2-yl]carbonyl}amino)benzenecarboxylate chemical structure, C24H24F3N3O3S, CAS 939893-74-0

Ethyl 4-({[3-amino-6-ethyl-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinolin-2-yl]carbonyl}amino)benzenecarboxylate

CAS 939893-74-0C₂₄H₂₄F₃N₃O₃S

3-Amino-N-(5-chloro-2-methoxyphenyl)-6-ethyl-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C22H21ClF3N3O2S, CAS 939888-82-1

3-Amino-N-(5-chloro-2-methoxyphenyl)-6-ethyl-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 939888-82-1C₂₂H₂₁ClF₃N₃O₂S

3-Amino-N-(2,4-dimethoxyphenyl)-6-ethyl-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C23H24F3N3O3S, CAS 939893-77-3

3-Amino-N-(2,4-dimethoxyphenyl)-6-ethyl-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 939893-77-3C₂₃H₂₄F₃N₃O₃S

N-(4-Acetylphenyl)-3-amino-6-ethyl-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C23H22F3N3O2S, CAS 939888-85-4

N-(4-Acetylphenyl)-3-amino-6-ethyl-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 939888-85-4C₂₃H₂₂F₃N₃O₂S

3-Amino-N-(2-chlorophenyl)-5-hydroxy-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C18H16ClN3O2S, CAS 2055778-23-7

3-Amino-N-(2-chlorophenyl)-5-hydroxy-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 2055778-23-7C₁₈H₁₆ClN₃O₂S