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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,729 to 1,776 of 6,403 chemicals

N-[3-Chloro-4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl]propanamide chemical structure, C18H26ClN3O2, CAS 898114-56-2
N-[3-Chloro-4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl]propanamide
CAS 898114-56-2C18H26ClN3O2
N-[3-Chloro-4-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]phenyl]-2-methylpropanamide chemical structure, C19H28ClN3O2, CAS 898116-08-0
N-[3-Chloro-4-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]phenyl]-2-methylpropanamide
CAS 898116-08-0C19H28ClN3O2
N-[3-Chloro-4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl]acetamide chemical structure, C17H24ClN3O2, CAS 898117-78-7
N-[3-Chloro-4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl]acetamide
CAS 898117-78-7C17H24ClN3O2
Ethyl 2-[4-(2-methoxyphenyl)piperazinyl]acetate chemical structure, C15H22N2O3, CAS 63854-11-5
Ethyl 2-[4-(2-methoxyphenyl)piperazinyl]acetate
CAS 63854-11-5C15H22N2O3
2-(2-Oxo-2-{4-[3-(trifluoromethyl)phenyl]piperazinyl}ethylthio)acetic acid chemical structure, C15H17F3N2O3S, CAS 847475-55-2
2-(2-Oxo-2-{4-[3-(trifluoromethyl)phenyl]piperazinyl}ethylthio)acetic acid
CAS 847475-55-2C15H17F3N2O3S
2-{2-[4-(4-Acetylphenyl)piperazinyl]-2-oxoethoxy}acetic acid chemical structure, C16H20N2O5, CAS 774195-22-1
2-{2-[4-(4-Acetylphenyl)piperazinyl]-2-oxoethoxy}acetic acid
CAS 774195-22-1C16H20N2O5
3-Methyl-1-(2-nitrophenyl)piperazine hydrochloride chemical structure, C11H16ClN3O2, CAS 299425-74-4
3-Methyl-1-(2-nitrophenyl)piperazine hydrochloride
CAS 299425-74-4C11H16ClN3O2
N-Ethyl-4-(4-fluorophenyl)piperazine-1-carboxamide chemical structure, C13H18FN3O, CAS 923121-38-4
N-Ethyl-4-(4-fluorophenyl)piperazine-1-carboxamide
CAS 923121-38-4C13H18FN3O
N-(1-Cyano-1,2-dimethylpropyl)-2-[4-(4-fluorophenyl)piperazin-1-yl]propanamide chemical structure, C19H27FN4O, CAS 923690-11-3
N-(1-Cyano-1,2-dimethylpropyl)-2-[4-(4-fluorophenyl)piperazin-1-yl]propanamide
CAS 923690-11-3C19H27FN4O
N-(1-Cyano-1,2-dimethylpropyl)-2-[4-(2-fluorophenyl)piperazin-1-yl]acetamide chemical structure, C18H25FN4O, CAS 923206-12-6
N-(1-Cyano-1,2-dimethylpropyl)-2-[4-(2-fluorophenyl)piperazin-1-yl]acetamide
CAS 923206-12-6C18H25FN4O
2-[4-(2-Methoxyphenyl)piperazin-1-yl]-N-prop-2-enylacetamide chemical structure, C16H23N3O2, CAS 930996-16-0
2-[4-(2-Methoxyphenyl)piperazin-1-yl]-N-prop-2-enylacetamide
CAS 930996-16-0C16H23N3O2
1-[4-[4-Nitro-3-(trifluoromethyl)phenyl]-1-piperazinyl]ethanone chemical structure, C13H14F3N3O3, CAS 940860-26-4
1-[4-[4-Nitro-3-(trifluoromethyl)phenyl]-1-piperazinyl]ethanone
CAS 940860-26-4C13H14F3N3O3
2-(4-(2-Hydroxyethyl)piperazin-1-yl)benzonitrile chemical structure, C13H17N3O, CAS 120116-37-2
2-(4-(2-Hydroxyethyl)piperazin-1-yl)benzonitrile
CAS 120116-37-2C13H17N3O
4-[4-(2-Chloroacetyl)-1-piperazinyl]benzoic Acid chemical structure, C13H15ClN2O3, CAS 944886-14-0
4-[4-(2-Chloroacetyl)-1-piperazinyl]benzoic Acid
CAS 944886-14-0C13H15ClN2O3
2-(4-Ethylpiperazin-1-yl)-5-nitrobenzaldehyde chemical structure, C13H17N3O3, CAS 952900-46-8
2-(4-Ethylpiperazin-1-yl)-5-nitrobenzaldehyde
CAS 952900-46-8C13H17N3O3
4-(3,5-Dimethylpiperazin-1-yl)aniline chemical structure, C12H19N3, CAS 251372-19-7
4-(3,5-Dimethylpiperazin-1-yl)aniline
CAS 251372-19-7C12H19N3
4-(4-Ethylpiperazin-1-yl)-3-(trifluoromethyl)aniline chemical structure, C13H18F3N3, CAS 915020-73-4
4-(4-Ethylpiperazin-1-yl)-3-(trifluoromethyl)aniline
CAS 915020-73-4C13H18F3N3
5-Methyl-2-(4-methylpiperazin-1-yl)aniline chemical structure, C12H19N3, CAS 946731-22-2
5-Methyl-2-(4-methylpiperazin-1-yl)aniline
CAS 946731-22-2C12H19N3
2-(4-Ethyl-1-piperazinyl)-5-methylbenzenamine chemical structure, C13H21N3, CAS 946719-47-7
2-(4-Ethyl-1-piperazinyl)-5-methylbenzenamine
CAS 946719-47-7C13H21N3
2-(3,5-Dimethyl-1-piperazinyl)-5-methylbenzenamine chemical structure, C13H21N3, CAS 946731-24-4
2-(3,5-Dimethyl-1-piperazinyl)-5-methylbenzenamine
CAS 946731-24-4C13H21N3
2-(4-Phenylpiperazin-1-yl)propanoic acid chemical structure, C13H18N2O2, CAS 856929-62-9
2-(4-Phenylpiperazin-1-yl)propanoic acid
CAS 856929-62-9C13H18N2O2
2-(4-Phenylpiperazin-1-yl)butanoic acid chemical structure, C14H20N2O2, CAS 946762-54-5
2-(4-Phenylpiperazin-1-yl)butanoic acid
CAS 946762-54-5C14H20N2O2
5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile chemical structure, C12H16N4, CAS 288251-82-1
5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile
CAS 288251-82-1C12H16N4
Ethyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate chemical structure, C13H18FN3O2, CAS 952919-05-0
Ethyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate
CAS 952919-05-0C13H18FN3O2