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Murcko scaffold

Ring system with 3 rings and 18 atoms

25 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
25
With full pages
12
Scaffold SMILES

O=C1c2ccccc2CN1CCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1c2ccccc2CN1CCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

2-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid chemical structure, C17H15NO3, CAS 96017-10-6
2-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid
CAS 96017-10-6C17H15NO3
3-(4-Hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid chemical structure, C17H15NO4, CAS 477858-45-0
3-(4-Hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid
CAS 477858-45-0C17H15NO4
3-(4-Cyanophenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid chemical structure, C18H14N2O3, CAS 338393-91-2
3-(4-Cyanophenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid
CAS 338393-91-2C18H14N2O3
Methyl 3-(4-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)propanoate chemical structure, C18H17NO4, CAS 477864-16-7
Methyl 3-(4-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)propanoate
CAS 477864-16-7C18H17NO4
2-(1-Benzyl-2-hydroxyethyl)-1-isoindolinone chemical structure, C17H17NO2, CAS 477864-32-7
2-(1-Benzyl-2-hydroxyethyl)-1-isoindolinone
CAS 477864-32-7C17H17NO2
3-(4-Hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)propanohydrazide chemical structure, C17H17N3O3, CAS 477871-35-5
3-(4-Hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)propanohydrazide
CAS 477871-35-5C17H17N3O3
(2S)-2-(1-Oxo-2,3-dihydro-1H-isoindol-2-yl)-3-phenylpropanoic acid chemical structure, C17H15NO3, CAS 105776-76-9
(2S)-2-(1-Oxo-2,3-dihydro-1H-isoindol-2-yl)-3-phenylpropanoic acid
CAS 105776-76-9C17H15NO3
(2R)-2-(1-Oxo-2,3-dihydro-1H-isoindol-2-yl)-3-phenylpropanoic acid chemical structure, C17H15NO3, CAS 1644301-24-5
(2R)-2-(1-Oxo-2,3-dihydro-1H-isoindol-2-yl)-3-phenylpropanoic acid
CAS 1644301-24-5C17H15NO3
(S)-3-(4-Hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)propanoic acid chemical structure, C17H15NO4, CAS 316801-28-2
(S)-3-(4-Hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)propanoic acid
CAS 316801-28-2C17H15NO4
(2R)-3-(4-Hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)propanoic acid chemical structure, C17H15NO4
(2R)-3-(4-Hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)propanoic acid
C17H15NO4
4-Amino-2-(3,4-dimethoxyphenethyl)-1-isoindolinone chemical structure, C18H20N2O3, CAS 900015-11-4
4-Amino-2-(3,4-dimethoxyphenethyl)-1-isoindolinone
CAS 900015-11-4C18H20N2O3
Hericenone B chemical structure, C27H31NO4, CAS 126654-53-3
Hericenone B
CAS 126654-53-3C27H31NO4
2-(3,4-Dimethoxyphenethyl)-4-nitro-1-isoindolinone chemical structure, C18H18N2O5, CAS 900015-09-0
2-(3,4-Dimethoxyphenethyl)-4-nitro-1-isoindolinone
CAS 900015-09-0C18H18N2O5
2-(2-(4-Hydroxyphenyl)ethyl)-5-methoxy-4-(pentylamino)-2,3-dihydro-1H-isoindol-1-one chemical structure, C22H28N2O3, CAS 194358-72-0
2-(2-(4-Hydroxyphenyl)ethyl)-5-methoxy-4-(pentylamino)-2,3-dihydro-1H-isoindol-1-one
CAS 194358-72-0C22H28N2O3
3-Oxo-2-phenethyl-2,3-dihydro-1H-isoindole-4-carboxylic acid chemical structure, C17H15NO3, CAS 943251-45-4
3-Oxo-2-phenethyl-2,3-dihydro-1H-isoindole-4-carboxylic acid
CAS 943251-45-4C17H15NO3
2-[2-(3,4-Dimethoxyphenyl)ethyl]-3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid chemical structure, C19H19NO5, CAS 943251-46-5
2-[2-(3,4-Dimethoxyphenyl)ethyl]-3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid
CAS 943251-46-5C19H19NO5
Isohericerin chemical structure, C27H33NO3, CAS 140381-53-9
Isohericerin
CAS 140381-53-9C27H33NO3
2-[2-(4-Chlorophenyl)ethyl]-3H-isoindol-1-one chemical structure, C16H14ClNO, CAS 869623-57-4
2-[2-(4-Chlorophenyl)ethyl]-3H-isoindol-1-one
CAS 869623-57-4C16H14ClNO
2-[2-(4-Chlorophenyl)ethyl]-3,3-dimethyl-2,3-dihydro-1H-isoindol-1-one chemical structure, C18H18ClNO, CAS 918867-77-3
2-[2-(4-Chlorophenyl)ethyl]-3,3-dimethyl-2,3-dihydro-1H-isoindol-1-one
CAS 918867-77-3C18H18ClNO
5-[(2E)-3,7-Dimethyl-5-oxoocta-2,6-dienyl]-4-hydroxy-6-methoxy-2-(2-phenylethyl)-3H-isoindol-1-one chemical structure, C27H31NO4, CAS 1416052-89-5
5-[(2E)-3,7-Dimethyl-5-oxoocta-2,6-dienyl]-4-hydroxy-6-methoxy-2-(2-phenylethyl)-3H-isoindol-1-one
CAS 1416052-89-5C27H31NO4
3-Oxo-2-phenethylisoindoline-4-carboxamide chemical structure, C17H16N2O2, CAS 1606995-96-3
3-Oxo-2-phenethylisoindoline-4-carboxamide
CAS 1606995-96-3C17H16N2O2
4-Amino-2-(2-phenylethyl)-2,3-dihydro-1H-isoindol-1-one chemical structure, C16H16N2O, CAS 1266750-01-9
4-Amino-2-(2-phenylethyl)-2,3-dihydro-1H-isoindol-1-one
CAS 1266750-01-9C16H16N2O
CC-3052 chemical structure, C20H21NO5, CAS 216884-02-5
CC-3052
CAS 216884-02-5C20H21NO5
Corallocin B chemical structure, C27H33NO4, CAS 2651353-09-0
Corallocin B
CAS 2651353-09-0C27H33NO4