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Murcko scaffold

Ring system with 3 rings and 26 atoms

72 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
26
Chemicals
72
With full pages
3
Scaffold SMILES

O=C(Cn1nc(C(=O)Nc2ccccc2)ccc1=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cn1nc(C(=O)Nc2ccccc2)ccc1=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 72 chemicals

N-(4-Methylphenyl)-6-oxo-1-[(phenylcarbamoyl)methyl]-1,6-dihydropyridazine-3-carboxamide chemical structure, C20H18N4O3, CAS 933254-10-5
N-(4-Methylphenyl)-6-oxo-1-[(phenylcarbamoyl)methyl]-1,6-dihydropyridazine-3-carboxamide
CAS 933254-10-5C20H18N4O3
6-Oxo-1-(2-oxo-2-(m-tolylamino)ethyl)-N-(p-tolyl)-1,6-dihydropyridazine-3-carboxamide chemical structure, C21H20N4O3, CAS 932990-70-0
6-Oxo-1-(2-oxo-2-(m-tolylamino)ethyl)-N-(p-tolyl)-1,6-dihydropyridazine-3-carboxamide
CAS 932990-70-0C21H20N4O3
1-{[(3,5-Dimethylphenyl)carbamoyl]methyl}-N-(4-methylphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide chemical structure, C22H22N4O3, CAS 933254-13-8
1-{[(3,5-Dimethylphenyl)carbamoyl]methyl}-N-(4-methylphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide
CAS 933254-13-8C22H22N4O3
1-(2-(Mesitylamino)-2-oxoethyl)-6-oxo-N-(p-tolyl)-1,6-dihydropyridazine-3-carboxamide chemical structure, C23H24N4O3, CAS 932990-75-5
1-(2-(Mesitylamino)-2-oxoethyl)-6-oxo-N-(p-tolyl)-1,6-dihydropyridazine-3-carboxamide
CAS 932990-75-5C23H24N4O3
Methyl 4-(2-{3-[(4-methylphenyl)carbamoyl]-6-oxo-1,6-dihydropyridazin-1-yl}acetamido)benzoate chemical structure, C22H20N4O5, CAS 932990-80-2
Methyl 4-(2-{3-[(4-methylphenyl)carbamoyl]-6-oxo-1,6-dihydropyridazin-1-yl}acetamido)benzoate
CAS 932990-80-2C22H20N4O5
1-({[3,5-Bis(trifluoromethyl)phenyl]carbamoyl}methyl)-N-(4-methylphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide chemical structure, C22H16F6N4O3, CAS 923211-04-5
1-({[3,5-Bis(trifluoromethyl)phenyl]carbamoyl}methyl)-N-(4-methylphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide
CAS 923211-04-5C22H16F6N4O3
1-(2-((3,5-Bis(trifluoromethyl)phenyl)amino)-2-oxoethyl)-N-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide chemical structure, C22H16F6N4O4, CAS 920368-09-8
1-(2-((3,5-Bis(trifluoromethyl)phenyl)amino)-2-oxoethyl)-N-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide
CAS 920368-09-8C22H16F6N4O4
1-{[(2-Methylphenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide chemical structure, C20H18N4O3, CAS 946366-59-2
1-{[(2-Methylphenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide
CAS 946366-59-2C20H18N4O3
1-{[(4-Methylphenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide chemical structure, C20H18N4O3, CAS 946207-74-5
1-{[(4-Methylphenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide
CAS 946207-74-5C20H18N4O3
1-(2-((2,3-Dimethylphenyl)amino)-2-oxoethyl)-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide chemical structure, C21H20N4O3, CAS 946316-74-1
1-(2-((2,3-Dimethylphenyl)amino)-2-oxoethyl)-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide
CAS 946316-74-1C21H20N4O3
1-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide chemical structure, C21H20N4O3, CAS 946287-34-9
1-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide
CAS 946287-34-9C21H20N4O3
1-(2-((4-Ethylphenyl)amino)-2-oxoethyl)-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide chemical structure, C21H20N4O3, CAS 946366-62-7
1-(2-((4-Ethylphenyl)amino)-2-oxoethyl)-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide
CAS 946366-62-7C21H20N4O3
1-{[(2,4-Dimethylphenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide chemical structure, C21H20N4O3, CAS 946207-77-8
1-{[(2,4-Dimethylphenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide
CAS 946207-77-8C21H20N4O3
1-{[(3,4-Dimethoxyphenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide chemical structure, C21H20N4O5, CAS 946287-38-3
1-{[(3,4-Dimethoxyphenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide
CAS 946287-38-3C21H20N4O5
1-{[(4-Acetamidophenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide chemical structure, C21H19N5O4, CAS 946366-68-3
1-{[(4-Acetamidophenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide
CAS 946366-68-3C21H19N5O4
1-{[(2-Fluorophenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide chemical structure, C19H15FN4O3, CAS 946287-42-9
1-{[(2-Fluorophenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide
CAS 946287-42-9C19H15FN4O3
Ethyl 2-{2-[6-oxo-3-(phenylcarbamoyl)-1,6-dihydropyridazin-1-yl]acetamido}benzoate chemical structure, C22H20N4O5, CAS 946207-83-6
Ethyl 2-{2-[6-oxo-3-(phenylcarbamoyl)-1,6-dihydropyridazin-1-yl]acetamido}benzoate
CAS 946207-83-6C22H20N4O5
Ethyl 4-{2-[6-oxo-3-(phenylcarbamoyl)-1,6-dihydropyridazin-1-yl]acetamido}benzoate chemical structure, C22H20N4O5, CAS 946287-46-3
Ethyl 4-{2-[6-oxo-3-(phenylcarbamoyl)-1,6-dihydropyridazin-1-yl]acetamido}benzoate
CAS 946287-46-3C22H20N4O5
1-(2-((3-Fluorophenyl)amino)-2-oxoethyl)-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide chemical structure, C19H15FN4O3, CAS 946316-96-7
1-(2-((3-Fluorophenyl)amino)-2-oxoethyl)-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide
CAS 946316-96-7C19H15FN4O3
1-(2-((4-Isopropylphenyl)amino)-2-oxoethyl)-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide chemical structure, C22H22N4O3, CAS 946366-85-4
1-(2-((4-Isopropylphenyl)amino)-2-oxoethyl)-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide
CAS 946366-85-4C22H22N4O3
1-{[(4-Butylphenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide chemical structure, C23H24N4O3, CAS 946287-60-1
1-{[(4-Butylphenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide
CAS 946287-60-1C23H24N4O3
1-(2-((3-Fluoro-4-methylphenyl)amino)-2-oxoethyl)-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide chemical structure, C20H17FN4O3, CAS 946366-89-8
1-(2-((3-Fluoro-4-methylphenyl)amino)-2-oxoethyl)-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide
CAS 946366-89-8C20H17FN4O3
1-{[(3,4-Difluorophenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide chemical structure, C19H14F2N4O3, CAS 946317-02-8
1-{[(3,4-Difluorophenyl)carbamoyl]methyl}-6-oxo-N-phenyl-1,6-dihydropyridazine-3-carboxamide
CAS 946317-02-8C19H14F2N4O3
6-Oxo-N-phenyl-1-({[4-(trifluoromethoxy)phenyl]carbamoyl}methyl)-1,6-dihydropyridazine-3-carboxamide chemical structure, C20H15F3N4O4, CAS 946207-94-9
6-Oxo-N-phenyl-1-({[4-(trifluoromethoxy)phenyl]carbamoyl}methyl)-1,6-dihydropyridazine-3-carboxamide
CAS 946207-94-9C20H15F3N4O4