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Murcko scaffold

Isothiazole scaffold

1,868 chemicals on CompoundList share this ring system.

Rings
1
Scaffold atoms
5
Chemicals
1,868
With full pages
279
Scaffold SMILES

c1cnsc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks. This is a very common single ring, so the list below is broad.

Substructure search with this scaffoldOpen the Isothiazole page
Murcko scaffold c1cnsc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,777 to 1,824 of 1,868 chemicals

(3R)-3-Amino-3-(1,2-thiazol-4-yl)propanamide chemical structure, C6H9N3OS, CAS 2171154-02-0
(3R)-3-Amino-3-(1,2-thiazol-4-yl)propanamide
CAS 2171154-02-0C6H9N3OS
1-Chloro-N-[(3-methoxy-1,2-thiazol-5-yl)methyl]-N-methylmethanesulfonamide chemical structure, C7H11ClN2O3S2, CAS 2138057-29-9
1-Chloro-N-[(3-methoxy-1,2-thiazol-5-yl)methyl]-N-methylmethanesulfonamide
CAS 2138057-29-9C7H11ClN2O3S2
2-Methoxy-2-(3-methoxy-1,2-thiazol-5-yl)ethan-1-amine chemical structure, C7H12N2O2S, CAS 2024244-39-9
2-Methoxy-2-(3-methoxy-1,2-thiazol-5-yl)ethan-1-amine
CAS 2024244-39-9C7H12N2O2S
(3S)-3-Formamido-3-(1,2-thiazol-5-yl)propanoic acid chemical structure, C7H8N2O3S, CAS 1997342-88-7
(3S)-3-Formamido-3-(1,2-thiazol-5-yl)propanoic acid
CAS 1997342-88-7C7H8N2O3S
Lithium(1+) 2-(3-chloro-1,2-thiazol-4-yl)-2,2-difluoroacetate chemical structure, C5HClF2LiNO2S, CAS 2758006-50-5
Lithium(1+) 2-(3-chloro-1,2-thiazol-4-yl)-2,2-difluoroacetate
CAS 2758006-50-5C5HClF2LiNO2S
2-(3-Chloro-1,2-thiazol-4-yl)-2,2-difluoroacetic acid chemical structure, C5H2ClF2NO2S, CAS 2757952-93-3
2-(3-Chloro-1,2-thiazol-4-yl)-2,2-difluoroacetic acid
CAS 2757952-93-3C5H2ClF2NO2S
3-(2-Methoxyethoxy)-1,2-thiazole-5-carboxylic acid chemical structure, C7H9NO4S, CAS 2870673-76-8
3-(2-Methoxyethoxy)-1,2-thiazole-5-carboxylic acid
CAS 2870673-76-8C7H9NO4S
3-(Propan-2-yloxy)-1,2-thiazole-5-carboxylic acid chemical structure, C7H9NO3S, CAS 2757916-68-8
3-(Propan-2-yloxy)-1,2-thiazole-5-carboxylic acid
CAS 2757916-68-8C7H9NO3S
2-Chloro-1-(5-methyl-1,2-thiazol-3-yl)ethan-1-one chemical structure, C6H6ClNOS, CAS 2758000-95-0
2-Chloro-1-(5-methyl-1,2-thiazol-3-yl)ethan-1-one
CAS 2758000-95-0C6H6ClNOS
5-Formyl-1,2-thiazole-4-carboxylic acid chemical structure, C5H3NO3S, CAS 2168114-80-3
5-Formyl-1,2-thiazole-4-carboxylic acid
CAS 2168114-80-3C5H3NO3S
3-Ethyl-1,2-thiazol-4-amine hydrochloride chemical structure, C5H9ClN2S, CAS 2763759-11-9
3-Ethyl-1,2-thiazol-4-amine hydrochloride
CAS 2763759-11-9C5H9ClN2S
2-Chloro-1-(3-methyl-1,2-thiazol-4-yl)ethan-1-one chemical structure, C6H6ClNOS, CAS 2764018-51-9
2-Chloro-1-(3-methyl-1,2-thiazol-4-yl)ethan-1-one
CAS 2764018-51-9C6H6ClNOS
4-Bromo-5-(2-bromoethyl)-1,2-thiazole chemical structure, C5H5Br2NS, CAS 2147747-14-4
4-Bromo-5-(2-bromoethyl)-1,2-thiazole
CAS 2147747-14-4C5H5Br2NS
4-Iodo-3-methoxy-1,2-thiazole-5-carboxylic acid chemical structure, C5H4INO3S, CAS 2763759-62-0
4-Iodo-3-methoxy-1,2-thiazole-5-carboxylic acid
CAS 2763759-62-0C5H4INO3S
2-(1,2-Thiazol-5-yl)ethane-1-thiol chemical structure, C5H7NS2, CAS 2764020-86-0
2-(1,2-Thiazol-5-yl)ethane-1-thiol
CAS 2764020-86-0C5H7NS2
4-Ethynyl-1,2-thiazole-3-carbaldehyde chemical structure, C6H3NOS, CAS 2763940-09-4
4-Ethynyl-1,2-thiazole-3-carbaldehyde
CAS 2763940-09-4C6H3NOS
Methyl 3-formyl-1,2-thiazole-5-carboxylate chemical structure, C6H5NO3S, CAS 2763750-63-4
Methyl 3-formyl-1,2-thiazole-5-carboxylate
CAS 2763750-63-4C6H5NO3S
2-Amino-1-(1,2-thiazol-3-yl)ethan-1-one hydrochloride chemical structure, C5H7ClN2OS, CAS 2866334-70-3
2-Amino-1-(1,2-thiazol-3-yl)ethan-1-one hydrochloride
CAS 2866334-70-3C5H7ClN2OS
2-Bromo-1-(1,2-thiazol-4-yl)ethan-1-one chemical structure, C5H4BrNOS, CAS 2153825-58-0
2-Bromo-1-(1,2-thiazol-4-yl)ethan-1-one
CAS 2153825-58-0C5H4BrNOS
4-(2-Bromoethyl)-1,2-thiazole chemical structure, C5H6BrNS, CAS 1999858-62-6
4-(2-Bromoethyl)-1,2-thiazole
CAS 1999858-62-6C5H6BrNS
5-Iodo-4-(2,2,2-trifluoroacetamido)-1,2-thiazole-3-carboxylic acid chemical structure, C6H2F3IN2O3S, CAS 2870645-17-1
5-Iodo-4-(2,2,2-trifluoroacetamido)-1,2-thiazole-3-carboxylic acid
CAS 2870645-17-1C6H2F3IN2O3S
4-Ethyl-1,2-thiazole-5-carbaldehyde chemical structure, C6H7NOS, CAS 2764015-97-4
4-Ethyl-1,2-thiazole-5-carbaldehyde
CAS 2764015-97-4C6H7NOS
Methyl 3-(bromomethyl)-1,2-thiazole-5-carboxylate chemical structure, C6H6BrNO2S, CAS 2763780-16-9
Methyl 3-(bromomethyl)-1,2-thiazole-5-carboxylate
CAS 2763780-16-9C6H6BrNO2S
3-(Propan-2-yl)-1,2-thiazol-4-amine hydrochloride chemical structure, C6H11ClN2S, CAS 2768332-34-7
3-(Propan-2-yl)-1,2-thiazol-4-amine hydrochloride
CAS 2768332-34-7C6H11ClN2S