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Murcko scaffold

Isothiazole scaffold

1,868 chemicals on CompoundList share this ring system.

Rings
1
Scaffold atoms
5
Chemicals
1,868
With full pages
279
Scaffold SMILES

c1cnsc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks. This is a very common single ring, so the list below is broad.

Substructure search with this scaffoldOpen the Isothiazole page
Murcko scaffold c1cnsc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,681 to 1,728 of 1,868 chemicals

3-{[(tert-Butoxy)carbonyl]amino}-5-methyl-1,2-thiazole-4-carboxylic acid chemical structure, C10H14N2O4S, CAS 2580189-14-4
3-{[(tert-Butoxy)carbonyl]amino}-5-methyl-1,2-thiazole-4-carboxylic acid
CAS 2580189-14-4C10H14N2O4S
Lithium(1+) 2-(5-chloro-1,2-thiazol-4-yl)-2,2-difluoroacetate chemical structure, C5HClF2LiNO2S, CAS 2839156-87-3
Lithium(1+) 2-(5-chloro-1,2-thiazol-4-yl)-2,2-difluoroacetate
CAS 2839156-87-3C5HClF2LiNO2S
Ethyl 5-amino-3-tert-butyl-1,2-thiazole-4-carboxylate chemical structure, C10H16N2O2S, CAS 2580199-33-1
Ethyl 5-amino-3-tert-butyl-1,2-thiazole-4-carboxylate
CAS 2580199-33-1C10H16N2O2S
tert-Butyl 4-amino-3-carbamoyl-1,2-thiazole-5-carboxylate chemical structure, C9H13N3O3S, CAS 2383612-99-3
tert-Butyl 4-amino-3-carbamoyl-1,2-thiazole-5-carboxylate
CAS 2383612-99-3C9H13N3O3S
tert-Butyl N-(4-hydroxy-2-methylbutyl)-N-[1-(3-methoxy-1,2-thiazol-5-yl)ethyl]carbamate chemical structure, C16H28N2O4S, CAS 2580243-07-6
tert-Butyl N-(4-hydroxy-2-methylbutyl)-N-[1-(3-methoxy-1,2-thiazol-5-yl)ethyl]carbamate
CAS 2580243-07-6C16H28N2O4S
5-{[(tert-Butoxy)carbonyl]amino}-1,2-thiazole-3-carboxylic acid chemical structure, C9H12N2O4S, CAS 2580249-22-3
5-{[(tert-Butoxy)carbonyl]amino}-1,2-thiazole-3-carboxylic acid
CAS 2580249-22-3C9H12N2O4S
tert-Butyl N-[1-oxo-1-(1,2-thiazol-3-yl)butan-2-yl]carbamate chemical structure, C12H18N2O3S, CAS 1996591-76-4
tert-Butyl N-[1-oxo-1-(1,2-thiazol-3-yl)butan-2-yl]carbamate
CAS 1996591-76-4C12H18N2O3S
(3-Methoxy-1,2-thiazol-4-yl)methanamine hydrochloride chemical structure, C5H9ClN2OS, CAS 2866353-11-7
(3-Methoxy-1,2-thiazol-4-yl)methanamine hydrochloride
CAS 2866353-11-7C5H9ClN2OS
1,2-Thiazole-4-sulfonyl fluoride chemical structure, C3H2FNO2S2, CAS 2293955-43-6
1,2-Thiazole-4-sulfonyl fluoride
CAS 2293955-43-6C3H2FNO2S2
tert-Butyl N-(4-cyano-3-methyl-1,2-thiazol-5-yl)-N-propylcarbamate chemical structure, C13H19N3O2S, CAS 2680706-63-0
tert-Butyl N-(4-cyano-3-methyl-1,2-thiazol-5-yl)-N-propylcarbamate
CAS 2680706-63-0C13H19N3O2S
tert-Butyl N-(4-cyano-3-methyl-1,2-thiazol-5-yl)carbamate chemical structure, C10H13N3O2S, CAS 2680697-47-4
tert-Butyl N-(4-cyano-3-methyl-1,2-thiazol-5-yl)carbamate
CAS 2680697-47-4C10H13N3O2S
tert-Butyl N-(3-chloro-4-cyano-1,2-thiazol-5-yl)carbamate chemical structure, C9H10ClN3O2S, CAS 2680828-29-7
tert-Butyl N-(3-chloro-4-cyano-1,2-thiazol-5-yl)carbamate
CAS 2680828-29-7C9H10ClN3O2S
3-(Propan-2-yl)-5-(2,2,2-trifluoroacetamido)-1,2-thiazole-4-carboxylic acid chemical structure, C9H9F3N2O3S, CAS 2680698-05-7
3-(Propan-2-yl)-5-(2,2,2-trifluoroacetamido)-1,2-thiazole-4-carboxylic acid
CAS 2680698-05-7C9H9F3N2O3S
5-{[(Prop-2-en-1-yloxy)carbonyl]amino}-3-(propan-2-yl)-1,2-thiazole-4-carboxylic acid chemical structure, C11H14N2O4S, CAS 2680849-63-0
5-{[(Prop-2-en-1-yloxy)carbonyl]amino}-3-(propan-2-yl)-1,2-thiazole-4-carboxylic acid
CAS 2680849-63-0C11H14N2O4S
3-tert-Butyl-5-{[(prop-2-en-1-yloxy)carbonyl]amino}-1,2-thiazole-4-carboxylic acid chemical structure, C12H16N2O4S, CAS 2680808-99-3
3-tert-Butyl-5-{[(prop-2-en-1-yloxy)carbonyl]amino}-1,2-thiazole-4-carboxylic acid
CAS 2680808-99-3C12H16N2O4S
5-Acetamido-3-ethyl-1,2-thiazole-4-carboxylic acid chemical structure, C8H10N2O3S, CAS 2680872-94-8
5-Acetamido-3-ethyl-1,2-thiazole-4-carboxylic acid
CAS 2680872-94-8C8H10N2O3S
3-Methyl-4-{[(prop-2-en-1-yloxy)carbonyl]amino}-1,2-thiazole-5-carboxylic acid chemical structure, C9H10N2O4S, CAS 2680801-94-7
3-Methyl-4-{[(prop-2-en-1-yloxy)carbonyl]amino}-1,2-thiazole-5-carboxylic acid
CAS 2680801-94-7C9H10N2O4S
3-Ethyl-5-{[(prop-2-en-1-yloxy)carbonyl]amino}-1,2-thiazole-4-carboxylic acid chemical structure, C10H12N2O4S, CAS 2680731-16-0
3-Ethyl-5-{[(prop-2-en-1-yloxy)carbonyl]amino}-1,2-thiazole-4-carboxylic acid
CAS 2680731-16-0C10H12N2O4S
tert-Butyl N-(4-acetyl-3-methyl-1,2-thiazol-5-yl)carbamate chemical structure, C11H16N2O3S, CAS 2680699-57-2
tert-Butyl N-(4-acetyl-3-methyl-1,2-thiazol-5-yl)carbamate
CAS 2680699-57-2C11H16N2O3S
4-{[(Prop-2-en-1-yloxy)carbonyl]amino}-1,2-thiazole-3-carboxylic acid chemical structure, C8H8N2O4S, CAS 2680700-71-2
4-{[(Prop-2-en-1-yloxy)carbonyl]amino}-1,2-thiazole-3-carboxylic acid
CAS 2680700-71-2C8H8N2O4S
tert-Butyl N-(5-bromo-1,2-thiazol-4-yl)carbamate chemical structure, C8H11BrN2O2S, CAS 2680701-04-4
tert-Butyl N-(5-bromo-1,2-thiazol-4-yl)carbamate
CAS 2680701-04-4C8H11BrN2O2S
3-Ethyl-5-(2,2,2-trifluoroacetamido)-1,2-thiazole-4-carboxylic acid chemical structure, C8H7F3N2O3S, CAS 2680811-71-4
3-Ethyl-5-(2,2,2-trifluoroacetamido)-1,2-thiazole-4-carboxylic acid
CAS 2680811-71-4C8H7F3N2O3S
tert-Butyl N-(4-ethynyl-3-methyl-1,2-thiazol-5-yl)carbamate chemical structure, C11H14N2O2S, CAS 2680624-26-2
tert-Butyl N-(4-ethynyl-3-methyl-1,2-thiazol-5-yl)carbamate
CAS 2680624-26-2C11H14N2O2S
3-Methyl-4-(trifluoroacetamido)-1,2-thiazole-5-carboxylic acid chemical structure, C7H5F3N2O3S, CAS 2303436-96-4
3-Methyl-4-(trifluoroacetamido)-1,2-thiazole-5-carboxylic acid
CAS 2303436-96-4C7H5F3N2O3S