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Murcko scaffold

Ring system with 3 rings and 19 atoms

39 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
39
With full pages
5
Scaffold SMILES

c1ccc(Sc2cnnc(-c3ccccc3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Sc2cnnc(-c3ccccc3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 39 of 39 chemicals

4-Fluorophenyl 3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl sulfide chemical structure, C16H9F4N3S, CAS 478048-09-8
4-Fluorophenyl 3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl sulfide
CAS 478048-09-8C16H9F4N3S
3-Phenyl-5-(phenylsulfanyl)-6-(trifluoromethyl)-1,2,4-triazine chemical structure, C16H10F3N3S, CAS 478048-14-5
3-Phenyl-5-(phenylsulfanyl)-6-(trifluoromethyl)-1,2,4-triazine
CAS 478048-14-5C16H10F3N3S
Ethyl 5-[(4-methoxyphenyl)sulfanyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate chemical structure, C20H16F3N3O3S, CAS 338956-96-0
Ethyl 5-[(4-methoxyphenyl)sulfanyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate
CAS 338956-96-0C20H16F3N3O3S
Ethyl 5-(phenylsulfanyl)-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate chemical structure, C19H14F3N3O2S, CAS 338957-00-9
Ethyl 5-(phenylsulfanyl)-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate
CAS 338957-00-9C19H14F3N3O2S
Ethyl 5-[(4-bromophenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C18H14BrN3O2S, CAS 338957-11-2
Ethyl 5-[(4-bromophenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-11-2C18H14BrN3O2S
Ethyl 3-phenyl-5-{[3-(trifluoromethyl)phenyl]sulfanyl}-1,2,4-triazine-6-carboxylate chemical structure, C19H14F3N3O2S, CAS 338957-12-3
Ethyl 3-phenyl-5-{[3-(trifluoromethyl)phenyl]sulfanyl}-1,2,4-triazine-6-carboxylate
CAS 338957-12-3C19H14F3N3O2S
Ethyl 5-[(2,6-dichlorophenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C18H13Cl2N3O2S, CAS 338957-13-4
Ethyl 5-[(2,6-dichlorophenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-13-4C18H13Cl2N3O2S
Ethyl 5-[(4-methoxyphenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C19H17N3O3S, CAS 338957-16-7
Ethyl 5-[(4-methoxyphenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-16-7C19H17N3O3S
Ethyl 5-[(2-methylphenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C19H17N3O2S, CAS 338957-17-8
Ethyl 5-[(2-methylphenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-17-8C19H17N3O2S
Ethyl 5-[(2,5-dimethylphenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C20H19N3O2S, CAS 338957-18-9
Ethyl 5-[(2,5-dimethylphenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-18-9C20H19N3O2S
Ethyl 5-[(2-chlorophenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C18H14ClN3O2S, CAS 338957-31-6
Ethyl 5-[(2-chlorophenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-31-6C18H14ClN3O2S
Ethyl 5-[(4-methylphenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C19H17N3O2S, CAS 338957-32-7
Ethyl 5-[(4-methylphenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-32-7C19H17N3O2S
Ethyl 5-[(4-fluorophenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C18H14FN3O2S, CAS 338957-33-8
Ethyl 5-[(4-fluorophenyl)sulfanyl]-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-33-8C18H14FN3O2S
Ethyl 5-{[2-(methoxycarbonyl)phenyl]sulfanyl}-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C20H17N3O4S, CAS 338957-34-9
Ethyl 5-{[2-(methoxycarbonyl)phenyl]sulfanyl}-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-34-9C20H17N3O4S
Ethyl 5-{[2-(methoxycarbonyl)phenyl]sulfanyl}-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate chemical structure, C21H16F3N3O4S, CAS 338957-59-8
Ethyl 5-{[2-(methoxycarbonyl)phenyl]sulfanyl}-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate
CAS 338957-59-8C21H16F3N3O4S
2-Chlorophenyl 6-methyl-3-phenyl-1,2,4-triazin-5-yl sulfide chemical structure, C16H12ClN3S, CAS 339013-28-4
2-Chlorophenyl 6-methyl-3-phenyl-1,2,4-triazin-5-yl sulfide
CAS 339013-28-4C16H12ClN3S
Methyl 4-{[6-methyl-3-(4-methylphenyl)-1,2,4-triazin-5-yl]sulfanyl}phenyl ether chemical structure, C18H17N3OS, CAS 339102-46-4
Methyl 4-{[6-methyl-3-(4-methylphenyl)-1,2,4-triazin-5-yl]sulfanyl}phenyl ether
CAS 339102-46-4C18H17N3OS
Methyl 2-({6-methyl-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazin-5-yl}sulfanyl)benzenecarboxylate chemical structure, C19H14F3N3O2S, CAS 339103-77-4
Methyl 2-({6-methyl-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazin-5-yl}sulfanyl)benzenecarboxylate
CAS 339103-77-4C19H14F3N3O2S
4-Fluorophenyl 6-methyl-3-(4-methylphenyl)-1,2,4-triazin-5-yl sulfide chemical structure, C17H14FN3S, CAS 478260-76-3
4-Fluorophenyl 6-methyl-3-(4-methylphenyl)-1,2,4-triazin-5-yl sulfide
CAS 478260-76-3C17H14FN3S
Ethyl 3-[3-(trifluoromethyl)phenyl]-5-{[3-(trifluoromethyl)phenyl]sulfanyl}-1,2,4-triazine-6-carboxylate chemical structure, C20H13F6N3O2S, CAS 338956-94-8
Ethyl 3-[3-(trifluoromethyl)phenyl]-5-{[3-(trifluoromethyl)phenyl]sulfanyl}-1,2,4-triazine-6-carboxylate
CAS 338956-94-8C20H13F6N3O2S
Ethyl 3-(4-methylphenyl)-5-(phenylsulfanyl)-1,2,4-triazine-6-carboxylate chemical structure, C19H17N3O2S, CAS 338965-77-8
Ethyl 3-(4-methylphenyl)-5-(phenylsulfanyl)-1,2,4-triazine-6-carboxylate
CAS 338965-77-8C19H17N3O2S
Ethyl 5-[(2-chlorophenyl)sulfanyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate chemical structure, C19H13ClF3N3O2S, CAS 338957-57-6
Ethyl 5-[(2-chlorophenyl)sulfanyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate
CAS 338957-57-6C19H13ClF3N3O2S
Ethyl 5-[(3-chlorophenyl)sulfanyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate chemical structure, C19H13ClF3N3O2S, CAS 338957-58-7
Ethyl 5-[(3-chlorophenyl)sulfanyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate
CAS 338957-58-7C19H13ClF3N3O2S
5-[(2,6-Dichlorophenyl)sulfanyl]-6-methyl-3-(4-methylphenyl)-1,2,4-triazine chemical structure, C17H13Cl2N3S, CAS 339013-38-6
5-[(2,6-Dichlorophenyl)sulfanyl]-6-methyl-3-(4-methylphenyl)-1,2,4-triazine
CAS 339013-38-6C17H13Cl2N3S