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Respiratory, allergy and digestive drugs

Thiethylperazine

Also known as Ethylthioperazine, Tietilperazina, Thiethylperazinum

CAS 1420-55-9Formula C22H29N3S2Molar mass 399.63 g/molEC 215-819-0
1 supplier listed
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Thiethylperazine chemical structure, C22H29N3S2, CAS 1420-55-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from acetone
Melting point
62 to 64 °C
Boiling point
227 °C
Solubility
WHITE TO FAINTLY YELLOW CRYSTALLINE POWDER, SLIGHT ODOR, FREELY SOL IN WATER, SOL IN MET…
HS code
293430
Category
Respiratory, allergy and digestive drugs
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Thiethylperazine?

Plain description, key identifiers and synonyms

Thiethylperazine is a member of the class of phenothiazines that is perazine substituted by a ethylsulfanyl group at position 2. It has a role as a phenothiazine antipsychotic drug, a histamine antagonist, a serotonergic antagonist, a dopaminergic antagonist, a muscarinic antagonist and an antiemetic. It is a member of phenothiazines and a N-methylpiperazine. It is functionally related to a perazine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-ethylsulfanyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
CAS number
1420-55-9 CAS number cross-checked
EC number
215-819-0
Molecular formula
C22H29N3S2
UNII
8ETK1WAF6R
MDL number
MFCD00865537
InChIKey
XCTYLCDETUVOIP-UHFFFAOYSA-N
InChI
InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3
SMILES (canonical and isomeric)
CCSC1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN4CCN(CC4)C

Synonyms

  • Ethylthioperazine
  • Tietilperazina
  • Thiethylperazinum
  • 2-(ethylsulfanyl)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
  • 3-Ethylmercapto-10-(1'-methylpiperazinyl-4'-propyl)phenothiazine
  • 2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
  • 10H-Phenothiazine, 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)-
  • Phenothiazine, 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)-
  • 2-(ethylthio)-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine
  • 10H-Phenothiazine, 2-(ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]-
  • Phenothiazine, 2-(ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]-
  • 2-(ethylsulfanyl)-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine
  • Torecan
  • 2-ethylsulfanyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
  • 2-(Ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine
  • Thiethylpipezazine
  • 2-Ethylthio-10-(3-(4-methylpiperazin-1-yl)propyl)phenothiazine
  • Theithylperazine
  • 2-(Ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine
  • Thioethylperazine
  • Norzine (*Dimaleate*)
  • GS-95 (*Dimaleate*)
  • Thiethylperazine (USAN/INN)
  • Norzine (Salt/Mix)
  • Torecan (Salt/Mix)
Show all 27 synonyms
  • Tresten (Salt/Mix)
  • Thiethylperazine - API Standards

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from acetoneexp.
Melting point
62 to 64 °Cexp.
Boiling point
227 °Cexp.
Solubility
WHITE TO FAINTLY YELLOW CRYSTALLINE POWDER, SLIGHT ODOR, FREELY SOL IN WATER, SOL IN METHANOL, PH (FRESHLY PREPARED 1 IN 100 SOLN) BETWEEN 2.8-3.8 /MALATE/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
399.63 g/molcalc.
Exact mass
399.1803 Dacalc.
LogP (octanol/water)
5.04calc.
Topological polar surface area
9.72 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
6calc.
Heavy atoms
27calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.46calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)Sc1ccccc1N2CCCN1CCNCC1

c1ccc2c(c1)Sc1ccccc1N2CCCN1CCNCC1

4 rings, 23 atoms, the 10-Piperazinylpropylphenothiazine ring system.

206 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Thiethylperazine suppliers

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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

1 supplier in 1 country

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Thiethylperazine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Antiemetics
  • Dopamine Antagonists

Roles

  • antagonist
  • antiemetic
  • antipsychotic agent
  • central nervous system depressant
  • central nervous system drug
  • cholinergic antagonist
  • cholinergic drug
  • dopaminergic agent
  • dopaminergic antagonist
  • first generation antipsychotic
  • histamine antagonist
  • histaminergic drug
  • muscarinic antagonist
  • neurotransmitter agent
  • pharmaceutical
  • phenothiazine antipsychotic drug
  • psychotropic drug
  • serotonergic antagonist
  • serotonergic drug
  • tranquilizing drug

Pharmacology

Thiethylperazine is a piperazine phenothiazine derivative and a dopamine antagonist used as antiemetic. Thiethylperazine blocks postsynaptic dopamine 2 (D2) receptors in the medullary chemoreceptor trigger zone (CTZ), thereby decreasing stimulation of the vomiting center in the brain. Peripherally, thiethylperazine blocks the vagus nerve in the gastrointestinal tract. In addition, this agent also shows antagonistic activities mediated through muscarinic receptors, H1-receptors, and alpha(1)-receptors.

How it is made

Bourquin et al, Helv Chim Acta 41, 1072 (1958).

Thiethylperazine is reacted with a double equimolar quantity of malic acid. (Malate)

Reacting 2-(ethylthio)-phenothiazine with 1-(3-chloropropyl)-4-methylpiperazine in presence of sodamide... Base is dissolved in suitable solvent & reacted with double molar quantity of maleic acid... US patent 3,336,197. (Maleate)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Thiethylperazine is traded under.

HS 2934.30Indicative HS code

Compounds containing in the structure a phenothiazine ring-system (whether or not…

World exports in 2024
$89.3M
−7.1% vs 2023, imports $97M
2019 to 2024
Top exporters
  1. Germany21.6%
  2. France * partner reported14.6%
  3. China13.0%
Top importers
  1. United States14.2%
  2. Brazil12.7%
  3. India * partner reported10.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Thiethylperazine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Thiethylperazine, based on the data on this page

What is Thiethylperazine?

Thiethylperazine is a member of the class of phenothiazines that is perazine substituted by a ethylsulfanyl group at position 2. It has a role as a phenothiazine antipsychotic drug, a histamine antagonist, a serotonergic antagonist, a dopaminergic antagonist, a muscarinic antagonist and an antiemetic.

What is the CAS number of Thiethylperazine?

The CAS registry number of Thiethylperazine is 1420-55-9.

What is the molecular formula and weight of Thiethylperazine?

The molecular formula of Thiethylperazine is C22H29N3S2 and its molar mass is 399.63 g/mol.

What is Thiethylperazine used for?

Use classes: Pharmaceuticals.

Is Thiethylperazine hazardous?

No GHS hazard classification for Thiethylperazine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Thiethylperazine?

Thiethylperazine is usually classified under HS code 293430 (Compounds containing in the structure a phenothiazine ring-system (whether or not…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Thiethylperazine?

CompoundList lists 1 supplier of Thiethylperazine in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Thiethylperazine?

Suppliers quote Thiethylperazine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Thiethylperazine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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