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Murcko scaffold

Ring system with 3 rings and 20 atoms

35 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
35
With full pages
5
Scaffold SMILES

O=C1C(=Cc2cccnc2)SC(=S)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=Cc2cccnc2)SC(=S)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 35 of 35 chemicals

(E)-4-(4-Oxo-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-3-yl)benzoic acid chemical structure, C16H10N2O3S2, CAS 329224-21-7
(E)-4-(4-Oxo-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-3-yl)benzoic acid
CAS 329224-21-7C16H10N2O3S2
4-[(5Z)-4-Oxo-5-(pyridin-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]benzoic acid chemical structure, C16H10N2O3S2, CAS 1427537-93-6
4-[(5Z)-4-Oxo-5-(pyridin-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]benzoic acid
CAS 1427537-93-6C16H10N2O3S2
3-(4-Chlorophenyl)-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H9ClN2OS2, CAS 294893-85-9
3-(4-Chlorophenyl)-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 294893-85-9C15H9ClN2OS2
3-(3,4-Dichlorophenyl)-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H8Cl2N2OS2, CAS 612803-16-4
3-(3,4-Dichlorophenyl)-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 612803-16-4C15H8Cl2N2OS2
(Z)-3-(4-Hydroxyphenyl)-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-4-one chemical structure, C15H10N2O2S2, CAS 612802-66-1
(Z)-3-(4-Hydroxyphenyl)-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-4-one
CAS 612802-66-1C15H10N2O2S2
3-(3,5-Dichlorophenyl)-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H8Cl2N2OS2, CAS 612803-08-4
3-(3,5-Dichlorophenyl)-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 612803-08-4C15H8Cl2N2OS2
3-(4-Bromophenyl)-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H9BrN2OS2, CAS 497229-85-3
3-(4-Bromophenyl)-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 497229-85-3C15H9BrN2OS2
3-Phenyl-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H10N2OS2, CAS 1164468-86-3
3-Phenyl-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 1164468-86-3C15H10N2OS2
(5E)-3-Phenyl-5-(pyridin-3-ylmethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C15H10N2OS2, CAS 92427-60-6
(5E)-3-Phenyl-5-(pyridin-3-ylmethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 92427-60-6C15H10N2OS2
(Z)-3-(2-Fluorophenyl)-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-4-one chemical structure, C15H9FN2OS2, CAS 488705-62-0
(Z)-3-(2-Fluorophenyl)-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-4-one
CAS 488705-62-0C15H9FN2OS2
3-(4-Oxo-5-pyridin-3-ylmethylene-2-thioxo-thiazolidin-3-yl)-benzoic acid chemical structure, C16H10N2O3S2, CAS 329224-22-8
3-(4-Oxo-5-pyridin-3-ylmethylene-2-thioxo-thiazolidin-3-yl)-benzoic acid
CAS 329224-22-8C16H10N2O3S2
(Z)-3-(4-Ethoxyphenyl)-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-4-one chemical structure, C17H14N2O2S2, CAS 356569-04-5
(Z)-3-(4-Ethoxyphenyl)-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-4-one
CAS 356569-04-5C17H14N2O2S2
3-(2-Methylphenyl)-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C16H12N2OS2, CAS 488793-42-6
3-(2-Methylphenyl)-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 488793-42-6C16H12N2OS2
3-(4-Fluorophenyl)-5-(3-pyridinylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H9FN2OS2, CAS 1164552-88-8
3-(4-Fluorophenyl)-5-(3-pyridinylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 1164552-88-8C15H9FN2OS2
(Z)-3-(3-Hydroxyphenyl)-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-4-one chemical structure, C15H10N2O2S2, CAS 488794-56-5
(Z)-3-(3-Hydroxyphenyl)-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-4-one
CAS 488794-56-5C15H10N2O2S2
(Z)-3-(2,3-Dimethylphenyl)-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-4-one chemical structure, C17H14N2OS2, CAS 488726-64-3
(Z)-3-(2,3-Dimethylphenyl)-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-4-one
CAS 488726-64-3C17H14N2OS2
3-(2-Methoxyphenyl)-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C16H12N2O2S2, CAS 488804-16-6
3-(2-Methoxyphenyl)-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 488804-16-6C16H12N2O2S2
(Z)-3-(2-Ethoxyphenyl)-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-4-one chemical structure, C17H14N2O2S2, CAS 488096-68-0
(Z)-3-(2-Ethoxyphenyl)-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-4-one
CAS 488096-68-0C17H14N2O2S2
(Z)-5-(Pyridin-3-ylmethylene)-2-thioxo-3-(m-tolyl)thiazolidin-4-one chemical structure, C16H12N2OS2, CAS 496795-97-2
(Z)-5-(Pyridin-3-ylmethylene)-2-thioxo-3-(m-tolyl)thiazolidin-4-one
CAS 496795-97-2C16H12N2OS2
3-(3-Fluoro-phenyl)-5-pyridin-3-ylmethylene-2-thioxo-thiazolidin-4-one chemical structure, C15H9FN2OS2, CAS 327054-25-1
3-(3-Fluoro-phenyl)-5-pyridin-3-ylmethylene-2-thioxo-thiazolidin-4-one
CAS 327054-25-1C15H9FN2OS2
(5Z)-3-(3-Chlorophenyl)-5-(pyridin-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H9ClN2OS2, CAS 314030-85-8
(5Z)-3-(3-Chlorophenyl)-5-(pyridin-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 314030-85-8C15H9ClN2OS2
3-(3-Bromophenyl)-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H9BrN2OS2, CAS 488826-62-6
3-(3-Bromophenyl)-5-(3-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 488826-62-6C15H9BrN2OS2
3-(4-Methylphenyl)-5-(3-pyridinylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C16H12N2OS2, CAS 1164486-59-2
3-(4-Methylphenyl)-5-(3-pyridinylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 1164486-59-2C16H12N2OS2
(E)-3-(3,4-Dimethylphenyl)-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-4-one chemical structure, C17H14N2OS2, CAS 487020-13-3
(E)-3-(3,4-Dimethylphenyl)-5-(pyridin-3-ylmethylene)-2-thioxothiazolidin-4-one
CAS 487020-13-3C17H14N2OS2