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Murcko scaffold

2,5-Pyrrolidinedione, 1-phenyl-3-(phenylthio)- scaffold

93 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
93
With full pages
31
Scaffold SMILES

O=C1CC(Sc2ccccc2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2,5-Pyrrolidinedione, 1-phenyl-3-(phenylthio)- page
Murcko scaffold O=C1CC(Sc2ccccc2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 93 chemicals

2,5-Pyrrolidinedione, 1-phenyl-3-(phenylthio)- chemical structure, C16H13NO2S, CAS 71724-33-9
2,5-Pyrrolidinedione, 1-phenyl-3-(phenylthio)-
CAS 71724-33-9C16H13NO2S
3-[(4-Methylphenyl)thio]-1-[2-(trifluoromethyl)phenyl]-2,5-pyrrolidinedione chemical structure, C18H14F3NO2S, CAS 301307-89-1
3-[(4-Methylphenyl)thio]-1-[2-(trifluoromethyl)phenyl]-2,5-pyrrolidinedione
CAS 301307-89-1C18H14F3NO2S
3-(4-Chlorophenyl)sulfanyl-1-(3,5-dichlorophenyl)pyrrolidine-2,5-dione chemical structure, C16H10Cl3NO2S, CAS 32809-05-5
3-(4-Chlorophenyl)sulfanyl-1-(3,5-dichlorophenyl)pyrrolidine-2,5-dione
CAS 32809-05-5C16H10Cl3NO2S
3-((2-(3-((2-Aminophenyl)thio)-2,5-dioxopyrrolidin-1-yl)phenyl)thio)propanenitrile chemical structure, C19H17N3O2S2, CAS 883039-79-0
3-((2-(3-((2-Aminophenyl)thio)-2,5-dioxopyrrolidin-1-yl)phenyl)thio)propanenitrile
CAS 883039-79-0C19H17N3O2S2
RefChem:345352 chemical structure, C17H13NO4S, CAS 301229-04-9
RefChem:345352
CAS 301229-04-9C17H13NO4S
2-[1-(4-Chlorophenyl)-2,5-dioxoazolidin-3-ylthio]benzoic acid chemical structure, C17H12ClNO4S, CAS 301683-47-6
2-[1-(4-Chlorophenyl)-2,5-dioxoazolidin-3-ylthio]benzoic acid
CAS 301683-47-6C17H12ClNO4S
4-{3-[(4-Chlorophenyl)thio]-2,5-dioxotetrahydro-1H-pyrrol-1-yl}-3-fluorobenzene-1-sulphonyl fluoride chemical structure, C16H10ClF2NO4S2, CAS 284674-62-0
4-{3-[(4-Chlorophenyl)thio]-2,5-dioxotetrahydro-1H-pyrrol-1-yl}-3-fluorobenzene-1-sulphonyl fluoride
CAS 284674-62-0C16H10ClF2NO4S2
2-{[1-(4-Methylphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid chemical structure, C18H15NO4S, CAS 301307-88-0
2-{[1-(4-Methylphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid
CAS 301307-88-0C18H15NO4S
2-{[1-(4-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid chemical structure, C17H12BrNO4S, CAS 300559-67-5
2-{[1-(4-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid
CAS 300559-67-5C17H12BrNO4S
2-((2,5-Dioxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidin-3-yl)thio)benzoic acid chemical structure, C18H12F3NO5S, CAS 278609-78-2
2-((2,5-Dioxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidin-3-yl)thio)benzoic acid
CAS 278609-78-2C18H12F3NO5S
2,5-Pyrrolidinedione, 3-[(4-methylphenyl)thio]-1-phenyl- chemical structure, C17H15NO2S, CAS 109448-23-9
2,5-Pyrrolidinedione, 3-[(4-methylphenyl)thio]-1-phenyl-
CAS 109448-23-9C17H15NO2S
2-{[1-(2-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid chemical structure, C17H12ClNO4S, CAS 301227-26-9
2-{[1-(2-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid
CAS 301227-26-9C17H12ClNO4S
2-{[1-(4-Ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid chemical structure, C19H17NO5S, CAS 308293-17-6
2-{[1-(4-Ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid
CAS 308293-17-6C19H17NO5S
2-{[1-(2,3-Dimethylphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid chemical structure, C19H17NO4S, CAS 314278-90-5
2-{[1-(2,3-Dimethylphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid
CAS 314278-90-5C19H17NO4S
2-({2,5-Dioxo-1-[2-(trifluoromethyl)phenyl]pyrrolidin-3-yl}sulfanyl)benzoic acid chemical structure, C18H12F3NO4S, CAS 300559-66-4
2-({2,5-Dioxo-1-[2-(trifluoromethyl)phenyl]pyrrolidin-3-yl}sulfanyl)benzoic acid
CAS 300559-66-4C18H12F3NO4S
2-({2,5-Dioxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl}sulfanyl)benzoic acid chemical structure, C18H12F3NO4S, CAS 301683-45-4
2-({2,5-Dioxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl}sulfanyl)benzoic acid
CAS 301683-45-4C18H12F3NO4S
2-{[1-(2,4-Dimethylphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid chemical structure, C19H17NO4S, CAS 301683-44-3
2-{[1-(2,4-Dimethylphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid
CAS 301683-44-3C19H17NO4S
2-{[1-(2-Ethylphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid chemical structure, C19H17NO4S, CAS 305372-99-0
2-{[1-(2-Ethylphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid
CAS 305372-99-0C19H17NO4S
2-((2,5-Dioxo-1-(2-((trifluoromethyl)thio)phenyl)pyrrolidin-3-yl)thio)benzoic acid chemical structure, C18H12F3NO4S2, CAS 302552-57-4
2-((2,5-Dioxo-1-(2-((trifluoromethyl)thio)phenyl)pyrrolidin-3-yl)thio)benzoic acid
CAS 302552-57-4C18H12F3NO4S2
2-{[1-(3-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid chemical structure, C17H12ClNO4S, CAS 302552-56-3
2-{[1-(3-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid
CAS 302552-56-3C17H12ClNO4S
1-(4-Bromophenyl)-3-[(4-chlorophenyl)sulfanyl]-2,5-pyrrolidinedione chemical structure, C16H11BrClNO2S, CAS 326920-95-0
1-(4-Bromophenyl)-3-[(4-chlorophenyl)sulfanyl]-2,5-pyrrolidinedione
CAS 326920-95-0C16H11BrClNO2S
2-((1-(4-Acetoxyphenyl)-2,5-dioxopyrrolidin-3-yl)thio)benzoic acid chemical structure, C19H15NO6S, CAS 305373-35-7
2-((1-(4-Acetoxyphenyl)-2,5-dioxopyrrolidin-3-yl)thio)benzoic acid
CAS 305373-35-7C19H15NO6S
2-{[1-(4-Methyl-2-nitrophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid chemical structure, C18H14N2O6S, CAS 302804-35-9
2-{[1-(4-Methyl-2-nitrophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid
CAS 302804-35-9C18H14N2O6S
2-{[1-(2-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid chemical structure, C17H12FNO4S, CAS 302804-34-8
2-{[1-(2-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}benzoic acid
CAS 302804-34-8C17H12FNO4S