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Murcko scaffold

1-Phenyl-3-(pyrimidin-2-ylsulfanyl)-pyrrolidine-2,5-dione scaffold

47 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
47
With full pages
38
Scaffold SMILES

O=C1CC(Sc2ncccn2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-3-(pyrimidin-2-ylsulfanyl)-pyrrolidine-2,5-dione page
Murcko scaffold O=C1CC(Sc2ncccn2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 47 of 47 chemicals

1-(4-Methoxyphenyl)-3-[(4-methyl-2-pyrimidinyl)sulfanyl]-2,5-pyrrolidinedione chemical structure, C16H15N3O3S, CAS 352659-51-9
1-(4-Methoxyphenyl)-3-[(4-methyl-2-pyrimidinyl)sulfanyl]-2,5-pyrrolidinedione
CAS 352659-51-9C16H15N3O3S
3-[(4-Methyl-2-pyrimidinyl)sulfanyl]-1-phenyl-2,5-pyrrolidinedione chemical structure, C15H13N3O2S, CAS 330833-65-3
3-[(4-Methyl-2-pyrimidinyl)sulfanyl]-1-phenyl-2,5-pyrrolidinedione
CAS 330833-65-3C15H13N3O2S
3-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-1-(4-methylphenyl)pyrrolidine-2,5-dione chemical structure, C17H17N3O2S, CAS 317324-82-6
3-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-1-(4-methylphenyl)pyrrolidine-2,5-dione
CAS 317324-82-6C17H17N3O2S
3-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-1-(2-ethylphenyl)pyrrolidine-2,5-dione chemical structure, C18H19N3O2S, CAS 373619-05-7
3-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-1-(2-ethylphenyl)pyrrolidine-2,5-dione
CAS 373619-05-7C18H19N3O2S
1-(2-Methoxyphenyl)-3-(4-methylpyrimidin-2-yl)sulfanylpyrrolidine-2,5-dione chemical structure, C16H15N3O3S, CAS 372494-46-7
1-(2-Methoxyphenyl)-3-(4-methylpyrimidin-2-yl)sulfanylpyrrolidine-2,5-dione
CAS 372494-46-7C16H15N3O3S
1-(4-Methylphenyl)-3-[(4-methylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C16H15N3O2S, CAS 364619-41-0
1-(4-Methylphenyl)-3-[(4-methylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 364619-41-0C16H15N3O2S
N-(4-{3-[(4-Methylpyrimidin-2-yl)sulfanyl]-2,5-dioxopyrrolidin-1-yl}benzenesulfonyl)acetamide chemical structure, C17H16N4O5S2, CAS 375830-26-5
N-(4-{3-[(4-Methylpyrimidin-2-yl)sulfanyl]-2,5-dioxopyrrolidin-1-yl}benzenesulfonyl)acetamide
CAS 375830-26-5C17H16N4O5S2
N-(4-{3-[(4-Methylpyrimidin-2-yl)sulfanyl]-2,5-dioxopyrrolidin-1-yl}phenyl)acetamide chemical structure, C17H16N4O3S, CAS 375360-05-7
N-(4-{3-[(4-Methylpyrimidin-2-yl)sulfanyl]-2,5-dioxopyrrolidin-1-yl}phenyl)acetamide
CAS 375360-05-7C17H16N4O3S
1-(4-Chlorophenyl)-3-(4,6-dimethylpyrimidin-2-yl)sulfanylpyrrolidine-2,5-dione chemical structure, C16H14ClN3O2S, CAS 377058-21-4
1-(4-Chlorophenyl)-3-(4,6-dimethylpyrimidin-2-yl)sulfanylpyrrolidine-2,5-dione
CAS 377058-21-4C16H14ClN3O2S
1-(4-Ethoxyphenyl)-3-pyrimidin-2-ylsulfanylpyrrolidine-2,5-dione chemical structure, C16H15N3O3S, CAS 354790-15-1
1-(4-Ethoxyphenyl)-3-pyrimidin-2-ylsulfanylpyrrolidine-2,5-dione
CAS 354790-15-1C16H15N3O3S
1-(2,4-Dimethoxyphenyl)-3-[(4-methylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C17H17N3O4S, CAS 370586-67-7
1-(2,4-Dimethoxyphenyl)-3-[(4-methylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 370586-67-7C17H17N3O4S
3-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-1-(4-ethoxyphenyl)pyrrolidine-2,5-dione chemical structure, C18H19N3O3S, CAS 354790-90-2
3-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-1-(4-ethoxyphenyl)pyrrolidine-2,5-dione
CAS 354790-90-2C18H19N3O3S
1-(4-Fluorophenyl)-3-[(4-methylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C15H12FN3O2S, CAS 385393-07-7
1-(4-Fluorophenyl)-3-[(4-methylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 385393-07-7C15H12FN3O2S
1-(2-Iodophenyl)-3-[(4-methylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C15H12IN3O2S, CAS 384350-68-9
1-(2-Iodophenyl)-3-[(4-methylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 384350-68-9C15H12IN3O2S
1-(4-Bromophenyl)-3-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C16H14BrN3O2S, CAS 370871-06-0
1-(4-Bromophenyl)-3-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 370871-06-0C16H14BrN3O2S
1-(4-Bromo-phenyl)-3-(4-methyl-pyrimidin-2-ylsulfanyl)-pyrrolidine-2,5-dione chemical structure, C15H12BrN3O2S, CAS 371143-58-7
1-(4-Bromo-phenyl)-3-(4-methyl-pyrimidin-2-ylsulfanyl)-pyrrolidine-2,5-dione
CAS 371143-58-7C15H12BrN3O2S
3-(4-Methyl-pyrimidin-2-ylsulfanyl)-1-m-tolyl-pyrrolidine-2,5-dione chemical structure, C16H15N3O2S, CAS 433941-51-6
3-(4-Methyl-pyrimidin-2-ylsulfanyl)-1-m-tolyl-pyrrolidine-2,5-dione
CAS 433941-51-6C16H15N3O2S
1-(2-Methoxy-4-nitrophenyl)-3-[(4-methylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C16H14N4O5S, CAS 433952-75-1
1-(2-Methoxy-4-nitrophenyl)-3-[(4-methylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 433952-75-1C16H14N4O5S
1-(3,4-Dichlorophenyl)-3-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C16H13Cl2N3O2S, CAS 433971-73-4
1-(3,4-Dichlorophenyl)-3-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 433971-73-4C16H13Cl2N3O2S
N-[4-[3-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-2,5-dioxopyrrolidin-1-yl]phenyl]acetamide chemical structure, C18H18N4O3S, CAS 543696-85-1
N-[4-[3-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-2,5-dioxopyrrolidin-1-yl]phenyl]acetamide
CAS 543696-85-1C18H18N4O3S
3-[(4-Methylpyrimidin-2-yl)sulfanyl]-1-(4-nitrophenyl)pyrrolidine-2,5-dione chemical structure, C15H12N4O4S, CAS 489396-92-1
3-[(4-Methylpyrimidin-2-yl)sulfanyl]-1-(4-nitrophenyl)pyrrolidine-2,5-dione
CAS 489396-92-1C15H12N4O4S
1-(2-Ethoxyphenyl)-3-[(4-methylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C17H17N3O3S, CAS 488723-19-9
1-(2-Ethoxyphenyl)-3-[(4-methylpyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 488723-19-9C17H17N3O3S
1-Phenyl-3-(pyrimidin-2-ylsulfanyl)-pyrrolidine-2,5-dione chemical structure, C14H11N3O2S, CAS 519145-94-9
1-Phenyl-3-(pyrimidin-2-ylsulfanyl)-pyrrolidine-2,5-dione
CAS 519145-94-9C14H11N3O2S
1-(4-Isopropyl-phenyl)-3-(pyrimidin-2-ylsulfanyl)-pyrrolidine-2,5-dione chemical structure, C17H17N3O2S, CAS 489401-60-7
1-(4-Isopropyl-phenyl)-3-(pyrimidin-2-ylsulfanyl)-pyrrolidine-2,5-dione
CAS 489401-60-7C17H17N3O2S