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Murcko scaffold

Ring system with 3 rings and 20 atoms

183 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
183
With full pages
19
Scaffold SMILES

O=S(=O)(c1ccccc1)c1coc(-c2ccccc2)n1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=S(=O)(c1ccccc1)c1coc(-c2ccccc2)n1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 183 chemicals

5-Oxazolamine, N,N-dimethyl-4-[(4-methylphenyl)sulfonyl]-2-phenyl- chemical structure, C18H18N2O3S, CAS 117847-47-9
5-Oxazolamine, N,N-dimethyl-4-[(4-methylphenyl)sulfonyl]-2-phenyl-
CAS 117847-47-9C18H18N2O3S
4-(Benzenesulfonyl)-2-(4-methoxyphenyl)-N-methyl-1,3-oxazol-5-amine chemical structure, C17H16N2O4S, CAS 305330-94-3
4-(Benzenesulfonyl)-2-(4-methoxyphenyl)-N-methyl-1,3-oxazol-5-amine
CAS 305330-94-3C17H16N2O4S
4-(Benzenesulfonyl)-N,N-dimethyl-2-phenyl-1,3-oxazol-5-amine chemical structure, C17H16N2O3S, CAS 313684-06-9
4-(Benzenesulfonyl)-N,N-dimethyl-2-phenyl-1,3-oxazol-5-amine
CAS 313684-06-9C17H16N2O3S
5-(Methylthio)-2-phenyl-4-tosyloxazole chemical structure, C17H15NO3S2, CAS 145317-92-6
5-(Methylthio)-2-phenyl-4-tosyloxazole
CAS 145317-92-6C17H15NO3S2
5-(Methylthio)-4-(phenylsulfonyl)-2-(p-tolyl)oxazole chemical structure, C17H15NO3S2, CAS 314747-50-7
5-(Methylthio)-4-(phenylsulfonyl)-2-(p-tolyl)oxazole
CAS 314747-50-7C17H15NO3S2
2-(4-Fluorophenyl)-5-(methylthio)-4-(phenylsulfonyl)-1,3-oxazole chemical structure, C16H12FNO3S2, CAS 850927-00-3
2-(4-Fluorophenyl)-5-(methylthio)-4-(phenylsulfonyl)-1,3-oxazole
CAS 850927-00-3C16H12FNO3S2
2-(2,4-Dichlorophenyl)-N,N-dimethyl-4-tosyloxazol-5-amine chemical structure, C18H16Cl2N2O3S, CAS 276263-62-8
2-(2,4-Dichlorophenyl)-N,N-dimethyl-4-tosyloxazol-5-amine
CAS 276263-62-8C18H16Cl2N2O3S
4-(Benzenesulfonyl)-2-(4-chlorophenyl)-N,N-dimethyl-1,3-oxazol-5-amine chemical structure, C17H15ClN2O3S, CAS 313684-03-6
4-(Benzenesulfonyl)-2-(4-chlorophenyl)-N,N-dimethyl-1,3-oxazol-5-amine
CAS 313684-03-6C17H15ClN2O3S
4-(Benzenesulfonyl)-2-(4-methoxyphenyl)-N,N-dimethyl-1,3-oxazol-5-amine chemical structure, C18H18N2O4S, CAS 492997-86-1
4-(Benzenesulfonyl)-2-(4-methoxyphenyl)-N,N-dimethyl-1,3-oxazol-5-amine
CAS 492997-86-1C18H18N2O4S
4-(4-Chlorophenyl)sulfonyl-N-methyl-2-(3-methylphenyl)-1,3-oxazol-5-amine chemical structure, C17H15ClN2O3S, CAS 330681-90-8
4-(4-Chlorophenyl)sulfonyl-N-methyl-2-(3-methylphenyl)-1,3-oxazol-5-amine
CAS 330681-90-8C17H15ClN2O3S
N,N-Dimethyl-4-(4-methylbenzenesulfonyl)-2-(2-methylphenyl)-1,3-oxazol-5-amine chemical structure, C19H20N2O3S, CAS 620558-77-2
N,N-Dimethyl-4-(4-methylbenzenesulfonyl)-2-(2-methylphenyl)-1,3-oxazol-5-amine
CAS 620558-77-2C19H20N2O3S
2-((2-Phenyl-4-tosyloxazol-5-yl)thio)acetamide chemical structure, C18H16N2O4S2, CAS 405920-33-4
2-((2-Phenyl-4-tosyloxazol-5-yl)thio)acetamide
CAS 405920-33-4C18H16N2O4S2
4-[(4-Methylphenyl)sulfonyl]-5-(methylsulfonyl)-2-phenyl-1,3-oxazole chemical structure, C17H15NO5S2, CAS 405920-35-6
4-[(4-Methylphenyl)sulfonyl]-5-(methylsulfonyl)-2-phenyl-1,3-oxazole
CAS 405920-35-6C17H15NO5S2
N-Methyl-4-(4-methylphenyl)sulfonyl-2-phenyl-1,3-oxazol-5-amine chemical structure, C17H16N2O3S, CAS 312606-69-2
N-Methyl-4-(4-methylphenyl)sulfonyl-2-phenyl-1,3-oxazol-5-amine
CAS 312606-69-2C17H16N2O3S
4-((4-Chlorophenyl)sulfonyl)-N-methyl-2-phenyloxazol-5-amine chemical structure, C16H13ClN2O3S, CAS 823828-24-6
4-((4-Chlorophenyl)sulfonyl)-N-methyl-2-phenyloxazol-5-amine
CAS 823828-24-6C16H13ClN2O3S
4-((4-Bromophenyl)sulfonyl)-N,N-dimethyl-2-(o-tolyl)oxazol-5-amine chemical structure, C18H17BrN2O3S, CAS 823828-27-9
4-((4-Bromophenyl)sulfonyl)-N,N-dimethyl-2-(o-tolyl)oxazol-5-amine
CAS 823828-27-9C18H17BrN2O3S
N-Ethyl-4-((4-fluorophenyl)sulfonyl)-2-(p-tolyl)oxazol-5-amine chemical structure, C18H17FN2O3S, CAS 823828-29-1
N-Ethyl-4-((4-fluorophenyl)sulfonyl)-2-(p-tolyl)oxazol-5-amine
CAS 823828-29-1C18H17FN2O3S
4-((4-Chlorophenyl)sulfonyl)-N-ethyl-2-(4-fluorophenyl)oxazol-5-amine chemical structure, C17H14ClFN2O3S, CAS 823828-30-4
4-((4-Chlorophenyl)sulfonyl)-N-ethyl-2-(4-fluorophenyl)oxazol-5-amine
CAS 823828-30-4C17H14ClFN2O3S
4-(Benzenesulfonyl)-2-(4-ethoxyphenyl)-N-methyl-1,3-oxazol-5-amine chemical structure, C18H18N2O4S, CAS 823829-05-6
4-(Benzenesulfonyl)-2-(4-ethoxyphenyl)-N-methyl-1,3-oxazol-5-amine
CAS 823829-05-6C18H18N2O4S
4-(Benzenesulfonyl)-2-(2-chlorophenyl)-N-ethyl-1,3-oxazol-5-amine chemical structure, C17H15ClN2O3S, CAS 823829-69-2
4-(Benzenesulfonyl)-2-(2-chlorophenyl)-N-ethyl-1,3-oxazol-5-amine
CAS 823829-69-2C17H15ClN2O3S
4-(4-Bromophenyl)sulfonyl-2-(2-chlorophenyl)-N,N-dimethyl-1,3-oxazol-5-amine chemical structure, C17H14BrClN2O3S, CAS 823829-78-3
4-(4-Bromophenyl)sulfonyl-2-(2-chlorophenyl)-N,N-dimethyl-1,3-oxazol-5-amine
CAS 823829-78-3C17H14BrClN2O3S
4-(4-Chlorophenyl)sulfonyl-2-(2-fluorophenyl)-N-methyl-1,3-oxazol-5-amine chemical structure, C16H12ClFN2O3S, CAS 823829-87-4
4-(4-Chlorophenyl)sulfonyl-2-(2-fluorophenyl)-N-methyl-1,3-oxazol-5-amine
CAS 823829-87-4C16H12ClFN2O3S
4-((4-Bromophenyl)sulfonyl)-N-ethyl-2-(4-methoxyphenyl)oxazol-5-amine chemical structure, C18H17BrN2O4S, CAS 823830-01-9
4-((4-Bromophenyl)sulfonyl)-N-ethyl-2-(4-methoxyphenyl)oxazol-5-amine
CAS 823830-01-9C18H17BrN2O4S
2-((2-Phenyl-4-(phenylsulfonyl)oxazol-5-yl)thio)acetamide chemical structure, C17H14N2O4S2, CAS 686736-75-4
2-((2-Phenyl-4-(phenylsulfonyl)oxazol-5-yl)thio)acetamide
CAS 686736-75-4C17H14N2O4S2