CompoundList
Sign in
Murcko scaffold

Ring system with 3 rings and 19 atoms

166 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
166
With full pages
15
Scaffold SMILES

O=C1C(=Cc2ccccc2)C=NN1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=Cc2ccccc2)C=NN1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 166 chemicals

4-((4-(Dimethylamino)phenyl)methylene)-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one chemical structure, C19H19N3O, CAS 25111-96-0
4-((4-(Dimethylamino)phenyl)methylene)-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
CAS 25111-96-0C19H19N3O
Benzenesulfonic acid, 4-chloro-3-(4-((4-(dimethylamino)phenyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)- chemical structure, C19H18ClN3O4S, CAS 65036-66-0
Benzenesulfonic acid, 4-chloro-3-(4-((4-(dimethylamino)phenyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)-
CAS 65036-66-0C19H18ClN3O4S
Benzenesulfonic acid, 4-[4-[[4-[bis(2-cyanoethyl)amino]phenyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]- chemical structure, C23H21N5O4S
Benzenesulfonic acid, 4-[4-[[4-[bis(2-cyanoethyl)amino]phenyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-
C23H21N5O4S
4-[4-[[4-(Dimethylamino)phenyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzenesulfonic acid chemical structure, C19H19N3O4S, CAS 33981-19-0
4-[4-[[4-(Dimethylamino)phenyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzenesulfonic acid
CAS 33981-19-0C19H19N3O4S
5-Methyl-4-(4-methylbenzylidene)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C18H16N2O, CAS 53316-56-6
5-Methyl-4-(4-methylbenzylidene)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
CAS 53316-56-6C18H16N2O
N-[4-[(1,5-Dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]phenyl]acetamide chemical structure, C19H17N3O2, CAS 313268-58-5
N-[4-[(1,5-Dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]phenyl]acetamide
CAS 313268-58-5C19H17N3O2
(4Z)-4-[[4-(Diethylamino)phenyl]methylidene]-5-methyl-2-phenylpyrazol-3-one chemical structure, C21H23N3O, CAS 75955-76-9
(4Z)-4-[[4-(Diethylamino)phenyl]methylidene]-5-methyl-2-phenylpyrazol-3-one
CAS 75955-76-9C21H23N3O
(4-(4-(4-Dimethylaminobenzyliden-1-yl)-3-methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid chemical structure, C20H19N3O3, CAS 117573-89-4
(4-(4-(4-Dimethylaminobenzyliden-1-yl)-3-methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid
CAS 117573-89-4C20H19N3O3
1-(4-Chlorophenyl)-3-methyl-4-[(4-methylphenyl)methylidene]-4,5-dihydro-1H-pyrazol-5-one chemical structure, C18H15ClN2O
1-(4-Chlorophenyl)-3-methyl-4-[(4-methylphenyl)methylidene]-4,5-dihydro-1H-pyrazol-5-one
C18H15ClN2O
(4Z)-2-(4-Chlorophenyl)-5-methyl-4-[(4-methylphenyl)methylidene]pyrazol-3-one chemical structure, C18H15ClN2O, CAS 333342-12-4
(4Z)-2-(4-Chlorophenyl)-5-methyl-4-[(4-methylphenyl)methylidene]pyrazol-3-one
CAS 333342-12-4C18H15ClN2O
(4E)-2-(3,4-Dichlorophenyl)-5-methyl-4-[(4-methylphenyl)methylidene]pyrazol-3-one chemical structure, C18H14Cl2N2O, CAS 354541-34-7
(4E)-2-(3,4-Dichlorophenyl)-5-methyl-4-[(4-methylphenyl)methylidene]pyrazol-3-one
CAS 354541-34-7C18H14Cl2N2O
2-(2-Chlorophenyl)-4-(2-ethoxybenzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C19H17ClN2O2, CAS 353771-65-0
2-(2-Chlorophenyl)-4-(2-ethoxybenzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one
CAS 353771-65-0C19H17ClN2O2
1-(4-Chlorophenyl)-4-(3,4-dimethoxybenzylidene)-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one chemical structure, C19H14ClF3N2O3, CAS 431999-74-5
1-(4-Chlorophenyl)-4-(3,4-dimethoxybenzylidene)-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one
CAS 431999-74-5C19H14ClF3N2O3
(4Z)-4-[(2-Bromo-5-ethoxy-4-methoxyphenyl)methylidene]-5-methyl-2-(3-methylphenyl)pyrazol-3-one chemical structure, C21H21BrN2O3, CAS 355003-16-6
(4Z)-4-[(2-Bromo-5-ethoxy-4-methoxyphenyl)methylidene]-5-methyl-2-(3-methylphenyl)pyrazol-3-one
CAS 355003-16-6C21H21BrN2O3
4-{4-[4-(Carboxymethoxy)-3-ethoxy-5-iodobenzylidene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}benzoic acid chemical structure, C22H19IN2O7, CAS 353771-08-1
4-{4-[4-(Carboxymethoxy)-3-ethoxy-5-iodobenzylidene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}benzoic acid
CAS 353771-08-1C22H19IN2O7
(4Z)-4-[(3,4-Diethoxyphenyl)methylidene]-5-methyl-2-(3-methylphenyl)pyrazol-3-one chemical structure, C22H24N2O3, CAS 353771-46-7
(4Z)-4-[(3,4-Diethoxyphenyl)methylidene]-5-methyl-2-(3-methylphenyl)pyrazol-3-one
CAS 353771-46-7C22H24N2O3
4-[4-(3-Chloro-5-ethoxy-4-hydroxybenzylidene)-5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzenesulfonamide chemical structure, C19H15ClF3N3O5S, CAS 433687-79-7
4-[4-(3-Chloro-5-ethoxy-4-hydroxybenzylidene)-5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzenesulfonamide
CAS 433687-79-7C19H15ClF3N3O5S
Ethyl 4-[4-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzoate chemical structure, C22H18ClF3N2O5, CAS 431927-18-3
Ethyl 4-[4-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzoate
CAS 431927-18-3C22H18ClF3N2O5
3-[(4E)-4-[(3-Ethoxy-4-hydroxyphenyl)methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid chemical structure, C20H18N2O5, CAS 6040-84-2
3-[(4E)-4-[(3-Ethoxy-4-hydroxyphenyl)methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
CAS 6040-84-2C20H18N2O5
3-[4-[(2-Bromo-4-hydroxy-5-methoxyphenyl)methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid chemical structure, C19H15BrN2O5, CAS 354547-72-1
3-[4-[(2-Bromo-4-hydroxy-5-methoxyphenyl)methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid
CAS 354547-72-1C19H15BrN2O5
4-[(4Z)-4-[[3-Methoxy-4-(2-methylpropoxy)phenyl]methylidene]-5-oxo-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide chemical structure, C22H22F3N3O5S, CAS 665008-67-3
4-[(4Z)-4-[[3-Methoxy-4-(2-methylpropoxy)phenyl]methylidene]-5-oxo-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
CAS 665008-67-3C22H22F3N3O5S
4-[(4,5-Dimethoxy-2-nitrophenyl)methylidene]-5-methyl-2-phenylpyrazol-3-one chemical structure, C19H17N3O5, CAS 10234-92-1
4-[(4,5-Dimethoxy-2-nitrophenyl)methylidene]-5-methyl-2-phenylpyrazol-3-one
CAS 10234-92-1C19H17N3O5
3-[(4Z)-4-(5-Chloro-2-ethoxybenzylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid chemical structure, C20H17ClN2O4, CAS 328966-95-6
3-[(4Z)-4-(5-Chloro-2-ethoxybenzylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid
CAS 328966-95-6C20H17ClN2O4
(4Z)-2-(3,4-Dichlorophenyl)-4-[(4-ethoxy-3-methoxyphenyl)methylidene]-5-methylpyrazol-3-one chemical structure, C20H18Cl2N2O3, CAS 1225468-42-7
(4Z)-2-(3,4-Dichlorophenyl)-4-[(4-ethoxy-3-methoxyphenyl)methylidene]-5-methylpyrazol-3-one
CAS 1225468-42-7C20H18Cl2N2O3