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Murcko scaffold

1-Phenyl-3-(pyridin-2-ylsulfanyl)pyrrolidine-2,5-dione scaffold

59 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 20
Chemicals: 59
With full pages: 13

Scaffold SMILES

O=C1CC(Sc2ccccn2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 1-Phenyl-3-(pyridin-2-ylsulfanyl)pyrrolidine-2,5-dione page

Murcko scaffold O=C1CC(Sc2ccccn2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 59 chemicals

1-(4-Chlorophenyl)-3-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]sulfanyl}dihydro-1H-pyrrole-2,5-dione chemical structure, C16H9Cl2F3N2O2S, CAS 303988-45-6

1-(4-Chlorophenyl)-3-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]sulfanyl}dihydro-1H-pyrrole-2,5-dione

CAS 303988-45-6C₁₆H₉Cl₂F₃N₂O₂S

2-((2,5-Dioxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidin-3-yl)thio)nicotinic acid chemical structure, C17H11F3N2O5S, CAS 280133-24-6

2-((2,5-Dioxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidin-3-yl)thio)nicotinic acid

CAS 280133-24-6C₁₇H₁₁F₃N₂O₅S

1-Phenyl-3-(pyridin-2-ylsulfanyl)pyrrolidine-2,5-dione chemical structure, C15H12N2O2S, CAS 71644-17-2

1-Phenyl-3-(pyridin-2-ylsulfanyl)pyrrolidine-2,5-dione

CAS 71644-17-2C₁₅H₁₂N₂O₂S

1-(4-Methylphenyl)-3-(pyridin-2-ylsulfanyl)pyrrolidine-2,5-dione chemical structure, C16H14N2O2S, CAS 281212-31-5

1-(4-Methylphenyl)-3-(pyridin-2-ylsulfanyl)pyrrolidine-2,5-dione

CAS 281212-31-5C₁₆H₁₄N₂O₂S

2-((1-(4-Nitrophenyl)-2,5-dioxopyrrolidin-3-yl)thio)nicotinic acid chemical structure, C16H11N3O6S, CAS 308293-33-6

2-((1-(4-Nitrophenyl)-2,5-dioxopyrrolidin-3-yl)thio)nicotinic acid

CAS 308293-33-6C₁₆H₁₁N₃O₆S

2-({2,5-Dioxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl}sulfanyl)pyridine-3-carboxylic acid chemical structure, C17H11F3N2O4S, CAS 302552-60-9

2-({2,5-Dioxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl}sulfanyl)pyridine-3-carboxylic acid

CAS 302552-60-9C₁₇H₁₁F₃N₂O₄S

2-{[1-(4-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}pyridine-3-carboxylic acid chemical structure, C17H14N2O5S, CAS 302804-31-5

2-{[1-(4-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}pyridine-3-carboxylic acid

CAS 302804-31-5C₁₇H₁₄N₂O₅S

2-{[1-(2-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}pyridine-3-carboxylic acid chemical structure, C16H11ClN2O4S, CAS 303033-72-9

2-{[1-(2-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}pyridine-3-carboxylic acid

CAS 303033-72-9C₁₆H₁₁ClN₂O₄S

2-{[1-(4-Iodo-2-methylphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}pyridine-3-carboxylic acid chemical structure, C17H13IN2O4S, CAS 459417-85-7

2-{[1-(4-Iodo-2-methylphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}pyridine-3-carboxylic acid

CAS 459417-85-7C₁₇H₁₃IN₂O₄S

1-(3-Methoxy-phenyl)-3-(pyridin-2-ylsulfanyl)-pyrrolidine-2,5-dione chemical structure, C16H14N2O3S, CAS 383900-59-2

1-(3-Methoxy-phenyl)-3-(pyridin-2-ylsulfanyl)-pyrrolidine-2,5-dione

CAS 383900-59-2C₁₆H₁₄N₂O₃S

1-(2,3-Dichlorophenyl)-3-(pyridin-2-ylsulfanyl)pyrrolidine-2,5-dione chemical structure, C15H10Cl2N2O2S, CAS 385424-42-0

1-(2,3-Dichlorophenyl)-3-(pyridin-2-ylsulfanyl)pyrrolidine-2,5-dione

CAS 385424-42-0C₁₅H₁₀Cl₂N₂O₂S

1-(4-Ethyl-phenyl)-3-(pyridin-2-ylsulfanyl)-pyrrolidine-2,5-dione chemical structure, C17H16N2O2S, CAS 371127-47-8

1-(4-Ethyl-phenyl)-3-(pyridin-2-ylsulfanyl)-pyrrolidine-2,5-dione

CAS 371127-47-8C₁₇H₁₆N₂O₂S

1-(4-Ethoxyphenyl)-3-(pyridin-2-ylsulfanyl)pyrrolidine-2,5-dione chemical structure, C17H16N2O3S, CAS 371232-87-0

1-(4-Ethoxyphenyl)-3-(pyridin-2-ylsulfanyl)pyrrolidine-2,5-dione

CAS 371232-87-0C₁₇H₁₆N₂O₃S

1-(4-Fluorophenyl)-3-(pyridin-2-ylsulfanyl)pyrrolidine-2,5-dione chemical structure, C15H11FN2O2S, CAS 385420-71-3

1-(4-Fluorophenyl)-3-(pyridin-2-ylsulfanyl)pyrrolidine-2,5-dione

CAS 385420-71-3C₁₅H₁₁FN₂O₂S

1-(3-Methylphenyl)-3-(pyridin-2-ylsulfanyl)pyrrolidine-2,5-dione chemical structure, C16H14N2O2S, CAS 433694-00-9

1-(3-Methylphenyl)-3-(pyridin-2-ylsulfanyl)pyrrolidine-2,5-dione

CAS 433694-00-9C₁₆H₁₄N₂O₂S

1-(3,4-Dichlorophenyl)-3-(2-pyridylthio)azolidine-2,5-dione chemical structure, C15H10Cl2N2O2S, CAS 433962-41-5

1-(3,4-Dichlorophenyl)-3-(2-pyridylthio)azolidine-2,5-dione

CAS 433962-41-5C₁₅H₁₀Cl₂N₂O₂S

2-({1-[2-(Ethoxycarbonyl)phenyl]-2,5-dioxopyrrolidin-3-yl}sulfanyl)pyridine-3-carboxylic acid chemical structure, C19H16N2O6S, CAS 526190-74-9

2-({1-[2-(Ethoxycarbonyl)phenyl]-2,5-dioxopyrrolidin-3-yl}sulfanyl)pyridine-3-carboxylic acid

CAS 526190-74-9C₁₉H₁₆N₂O₆S

2-{[1-(4-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}pyridine-3-carboxylic acid chemical structure, C16H11FN2O4S, CAS 496779-17-0

2-{[1-(4-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}pyridine-3-carboxylic acid

CAS 496779-17-0C₁₆H₁₁FN₂O₄S

2-((1-(2-Bromo-4-methylphenyl)-2,5-dioxopyrrolidin-3-yl)thio)nicotinic acid chemical structure, C17H13BrN2O4S, CAS 496779-20-5

2-((1-(2-Bromo-4-methylphenyl)-2,5-dioxopyrrolidin-3-yl)thio)nicotinic acid

CAS 496779-20-5C₁₇H₁₃BrN₂O₄S

2-[1-(2-Ethylphenyl)-2,5-dioxoazolidin-3-ylthio]pyridine-3-carboxylic acid chemical structure, C18H16N2O4S, CAS 692267-46-2

2-[1-(2-Ethylphenyl)-2,5-dioxoazolidin-3-ylthio]pyridine-3-carboxylic acid

CAS 692267-46-2C₁₈H₁₆N₂O₄S

2-[1-(3-Methylphenyl)-2,5-dioxoazolidin-3-ylthio]pyridine-3-carboxylic acid chemical structure, C17H14N2O4S, CAS 643746-44-5

2-[1-(3-Methylphenyl)-2,5-dioxoazolidin-3-ylthio]pyridine-3-carboxylic acid

CAS 643746-44-5C₁₇H₁₄N₂O₄S

2-({1-[4-Chloro-3-(trifluoromethyl)phenyl]-2,5-dioxopyrrolidin-3-yl}sulfanyl)pyridine-3-carboxylic acid chemical structure, C17H10ClF3N2O4S, CAS 670255-07-9

2-({1-[4-Chloro-3-(trifluoromethyl)phenyl]-2,5-dioxopyrrolidin-3-yl}sulfanyl)pyridine-3-carboxylic acid

CAS 670255-07-9C₁₇H₁₀ClF₃N₂O₄S

2-((1-(4-Methyl-2-nitrophenyl)-2,5-dioxopyrrolidin-3-yl)thio)nicotinic acid chemical structure, C17H13N3O6S, CAS 643746-45-6

2-((1-(4-Methyl-2-nitrophenyl)-2,5-dioxopyrrolidin-3-yl)thio)nicotinic acid

CAS 643746-45-6C₁₇H₁₃N₃O₆S

2-((1-(2-Butoxyphenyl)-2,5-dioxopyrrolidin-3-yl)thio)nicotinic acid chemical structure, C20H20N2O5S, CAS 643746-43-4

2-((1-(2-Butoxyphenyl)-2,5-dioxopyrrolidin-3-yl)thio)nicotinic acid

CAS 643746-43-4C₂₀H₂₀N₂O₅S