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Murcko scaffold

2,8-Dioxaspiro[4.5]decan-1-one scaffold

12 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
12
With full pages
3
Scaffold SMILES

O=C1OCCC12CCOCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2,8-Dioxaspiro[4.5]decan-1-one page
Murcko scaffold O=C1OCCC12CCOCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

2,8-Dioxaspiro[4.5]decan-1-one chemical structure, C8H12O3, CAS 1690338-28-3
2,8-Dioxaspiro[4.5]decan-1-one
CAS 1690338-28-3C8H12O3
3-(Iodomethyl)-2,8-dioxaspiro[4.5]decan-1-one chemical structure, C9H13IO3, CAS 2246354-70-9
3-(Iodomethyl)-2,8-dioxaspiro[4.5]decan-1-one
CAS 2246354-70-9C9H13IO3
(1-Oxo-2,8-dioxaspiro[4.5]decan-3-yl)methanesulfonyl chloride chemical structure, C9H13ClO5S, CAS 2309446-43-1
(1-Oxo-2,8-dioxaspiro[4.5]decan-3-yl)methanesulfonyl chloride
CAS 2309446-43-1C9H13ClO5S
3-(Difluoromethyl)-1-oxo-2,8-dioxaspiro[4.5]decane-3-carboxylic acid chemical structure, C10H12F2O5, CAS 2171894-65-6
3-(Difluoromethyl)-1-oxo-2,8-dioxaspiro[4.5]decane-3-carboxylic acid
CAS 2171894-65-6C10H12F2O5
1-Oxo-3-(trifluoromethyl)-2,8-dioxaspiro[4.5]decane-3-carboxylic acid chemical structure, C10H11F3O5, CAS 2172591-77-2
1-Oxo-3-(trifluoromethyl)-2,8-dioxaspiro[4.5]decane-3-carboxylic acid
CAS 2172591-77-2C10H11F3O5
3-tert-Butyl-1-oxo-2,8-dioxaspiro[4.5]decane-3-carboxylic acid chemical structure, C13H20O5, CAS 2172053-88-0
3-tert-Butyl-1-oxo-2,8-dioxaspiro[4.5]decane-3-carboxylic acid
CAS 2172053-88-0C13H20O5
3-Ethyl-1-oxo-2,8-dioxaspiro[4.5]decane-3-carboxylic acid chemical structure, C11H16O5, CAS 2172451-54-4
3-Ethyl-1-oxo-2,8-dioxaspiro[4.5]decane-3-carboxylic acid
CAS 2172451-54-4C11H16O5
1-Oxo-3-(propan-2-yl)-2,8-dioxaspiro[4.5]decane-3-carboxylic acid chemical structure, C12H18O5, CAS 2172589-40-9
1-Oxo-3-(propan-2-yl)-2,8-dioxaspiro[4.5]decane-3-carboxylic acid
CAS 2172589-40-9C12H18O5
1-Oxo-3-propyl-2,8-dioxaspiro[4.5]decane-3-carboxylic acid chemical structure, C12H18O5, CAS 2172091-37-9
1-Oxo-3-propyl-2,8-dioxaspiro[4.5]decane-3-carboxylic acid
CAS 2172091-37-9C12H18O5
3-Methyl-1-oxo-2,8-dioxaspiro[4.5]decane-3-carboxylic acid chemical structure, C10H14O5, CAS 2171896-11-8
3-Methyl-1-oxo-2,8-dioxaspiro[4.5]decane-3-carboxylic acid
CAS 2171896-11-8C10H14O5
{1-Oxo-2,8-dioxaspiro[4.5]decan-3-yl}methanesulfonamide chemical structure, C9H15NO5S, CAS 2580222-81-5
{1-Oxo-2,8-dioxaspiro[4.5]decan-3-yl}methanesulfonamide
CAS 2580222-81-5C9H15NO5S
{1-Oxo-2,8-dioxaspiro[4.5]decan-3-yl}methanesulfonyl fluoride chemical structure, C9H13FO5S, CAS 2648956-64-1
{1-Oxo-2,8-dioxaspiro[4.5]decan-3-yl}methanesulfonyl fluoride
CAS 2648956-64-1C9H13FO5S