Murcko scaffold
8-Oxa-1-azaspiro[4.5]decane scaffold
95 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 10
- Chemicals
- 95
- With full pages
- 11
Scaffold SMILES
C1CNC2(C1)CCOCC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 95 chemicals
![8-Oxa-1-azaspiro[4.5]decane chemical structure, C8H15NO, CAS 51130-63-3](/s/FDDQZACIAJOJFY-UHFFFAOYSA-N.svg)
8-Oxa-1-azaspiro[4.5]decane
CAS 51130-63-3C8H15NO
![Ethyl 8-oxa-1-azaspiro[4.5]decane-2-carboxylate chemical structure, C11H19NO3, CAS 1272656-90-2](/s/QXZSSQNYUNNRJG-UHFFFAOYSA-N.svg)
Ethyl 8-oxa-1-azaspiro[4.5]decane-2-carboxylate
CAS 1272656-90-2C11H19NO3
![8-Oxa-1-azaspiro[4.5]decane hydrochloride chemical structure, C8H16ClNO, CAS 1427378-94-6](/s/GGZFYTDIYOCZCB-UHFFFAOYSA-N.svg)
8-Oxa-1-azaspiro[4.5]decane hydrochloride
CAS 1427378-94-6C8H16ClNO
![8-Oxa-1-azaspiro[4.5]decane-2-carboxylic acid chemical structure, C9H15NO3, CAS 1367705-58-5](/s/XXPMSRKJQZYENR-UHFFFAOYSA-N.svg)
8-Oxa-1-azaspiro[4.5]decane-2-carboxylic acid
CAS 1367705-58-5C9H15NO3
![8-Oxa-1-azaspiro[4.5]decan-4-ol chemical structure, C8H15NO2, CAS 1543318-40-6](/s/RVMCIARZPJYVEW-UHFFFAOYSA-N.svg)
8-Oxa-1-azaspiro[4.5]decan-4-ol
CAS 1543318-40-6C8H15NO2
![1-Methyl-8-oxa-1-azaspiro[4.5]decan-4-amine chemical structure, C9H18N2O, CAS 1543360-20-8](/s/NLZXEVBDUYONBM-UHFFFAOYSA-N.svg)
1-Methyl-8-oxa-1-azaspiro[4.5]decan-4-amine
CAS 1543360-20-8C9H18N2O
![8-Oxa-1-azaspiro[4.5]decane-4-carboxylic acid chemical structure, C9H15NO3, CAS 1545506-60-2](/s/XDBJSIHYLWQLGH-UHFFFAOYSA-N.svg)
8-Oxa-1-azaspiro[4.5]decane-4-carboxylic acid
CAS 1545506-60-2C9H15NO3
![{8-Oxa-1-azaspiro[4.5]decan-4-yl}methanol chemical structure, C9H17NO2, CAS 1784133-53-4](/s/YMHUAOJVKFCXLM-UHFFFAOYSA-N.svg)
{8-Oxa-1-azaspiro[4.5]decan-4-yl}methanol
CAS 1784133-53-4C9H17NO2
![Methyl 8-oxa-1-azaspiro[4.5]decane-4-carboxylate chemical structure, C10H17NO3, CAS 1784138-21-1](/s/GLVVXSGWRMFHHG-UHFFFAOYSA-N.svg)
Methyl 8-oxa-1-azaspiro[4.5]decane-4-carboxylate
CAS 1784138-21-1C10H17NO3
![4,4-Difluoro-8-oxa-1-azaspiro[4.5]decane chemical structure, C8H13F2NO, CAS 1781297-12-8](/s/PMTYFXQJWFPIRM-UHFFFAOYSA-N.svg)
4,4-Difluoro-8-oxa-1-azaspiro[4.5]decane
CAS 1781297-12-8C8H13F2NO
![8-Oxa-1-azaspiro[4.5]decan-3-ol chemical structure, C8H15NO2, CAS 1892474-88-2](/s/VBGNAFFFWRXMFL-UHFFFAOYSA-N.svg)
8-Oxa-1-azaspiro[4.5]decan-3-ol
CAS 1892474-88-2C8H15NO2
![3-Fluoro-8-oxa-1-azaspiro[4.5]decane chemical structure, C8H14FNO, CAS 1892412-08-6](/s/NMGHJFCJXFFEOB-UHFFFAOYSA-N.svg)
3-Fluoro-8-oxa-1-azaspiro[4.5]decane
CAS 1892412-08-6C8H14FNO
![4-Fluoro-8-oxa-1-azaspiro[4.5]decane chemical structure, C8H14FNO, CAS 1895169-72-8](/s/OHJOTHYSFYMQAP-UHFFFAOYSA-N.svg)
4-Fluoro-8-oxa-1-azaspiro[4.5]decane
CAS 1895169-72-8C8H14FNO
![3,3-Difluoro-8-oxa-1-azaspiro[4.5]decane chemical structure, C8H13F2NO, CAS 1888996-41-5](/s/OLFWKOULGVYNHN-UHFFFAOYSA-N.svg)
3,3-Difluoro-8-oxa-1-azaspiro[4.5]decane
CAS 1888996-41-5C8H13F2NO
![8-Oxa-1-azaspiro[4.5]decan-3-ol hydrochloride chemical structure, C8H16ClNO2, CAS 1894271-51-2](/s/XCUAZRCQTNGCMQ-UHFFFAOYSA-N.svg)
8-Oxa-1-azaspiro[4.5]decan-3-ol hydrochloride
CAS 1894271-51-2C8H16ClNO2
![3-Fluoro-8-oxa-1-azaspiro[4.5]decane hydrochloride chemical structure, C8H15ClFNO, CAS 1896602-20-2](/s/KFXFFHCMTFNBDH-UHFFFAOYSA-N.svg)
3-Fluoro-8-oxa-1-azaspiro[4.5]decane hydrochloride
CAS 1896602-20-2C8H15ClFNO
![3,3-Difluoro-8-oxa-1-azaspiro[4.5]decane hydrochloride chemical structure, C8H14ClF2NO, CAS 1888996-42-6](/s/IBHREJHVJDSTGR-UHFFFAOYSA-N.svg)
3,3-Difluoro-8-oxa-1-azaspiro[4.5]decane hydrochloride
CAS 1888996-42-6C8H14ClF2NO
![8-Oxa-1-azaspiro[4.5]decane-2-carbonitrile chemical structure, C9H14N2O, CAS 2091615-72-2](/s/WIALEIVBBDTFHN-UHFFFAOYSA-N.svg)
8-Oxa-1-azaspiro[4.5]decane-2-carbonitrile
CAS 2091615-72-2C9H14N2O
![Ethyl 8-oxa-1-azaspiro[4.5]decane-4-carboxylate chemical structure, C11H19NO3, CAS 2090138-86-4](/s/XOIWHDNZUZHFOI-UHFFFAOYSA-N.svg)
Ethyl 8-oxa-1-azaspiro[4.5]decane-4-carboxylate
CAS 2090138-86-4C11H19NO3
![tert-Butyl N-{8-oxa-1-azaspiro[4.5]decan-3-yl}carbamate hydrochloride chemical structure, C13H25ClN2O3, CAS 2219371-52-3](/s/VPUAFMZZGVHITD-UHFFFAOYSA-N.svg)
tert-Butyl N-{8-oxa-1-azaspiro[4.5]decan-3-yl}carbamate hydrochloride
CAS 2219371-52-3C13H25ClN2O3
![tert-Butyl N-{8-oxa-1-azaspiro[4.5]decan-3-yl}carbamate chemical structure, C13H24N2O3, CAS 2219371-51-2](/s/NTVMDPWQPMIUAO-UHFFFAOYSA-N.svg)
tert-Butyl N-{8-oxa-1-azaspiro[4.5]decan-3-yl}carbamate
CAS 2219371-51-2C13H24N2O3
![tert-Butyl 3-amino-8-oxa-1-azaspiro[4.5]decane-1-carboxylate hydrochloride chemical structure, C13H25ClN2O3, CAS 2253639-36-8](/s/VYGMMGLKICYUNZ-UHFFFAOYSA-N.svg)
tert-Butyl 3-amino-8-oxa-1-azaspiro[4.5]decane-1-carboxylate hydrochloride
CAS 2253639-36-8C13H25ClN2O3
![tert-Butyl 3-amino-8-oxa-1-azaspiro[4.5]decane-1-carboxylate chemical structure, C13H24N2O3, CAS 2253631-93-3](/s/OWFZMDKQLWXJNN-UHFFFAOYSA-N.svg)
tert-Butyl 3-amino-8-oxa-1-azaspiro[4.5]decane-1-carboxylate
CAS 2253631-93-3C13H24N2O3
![N,N-Dimethyl-8-oxa-1-azaspiro[4.5]decan-3-amine chemical structure, C10H20N2O, CAS 2248368-97-8](/s/JDMOFOUQATZQCF-UHFFFAOYSA-N.svg)
N,N-Dimethyl-8-oxa-1-azaspiro[4.5]decan-3-amine
CAS 2248368-97-8C10H20N2O
- 1-Methyl-8-oxa-1-azaspiro[4.5]decan-3-amine2248291-75-8C9H18N2O
- 8-Oxa-1-azaspiro[4.5]decane-3-carboxylic acid hydrochloride2287334-74-9C9H16ClNO3
- 8-Oxa-1-azaspiro[4.5]decane-3-carboxylic acid2287288-71-3C9H15NO3
- 1-((tert-Butoxy)carbonyl)-8-oxa-1-azaspiro(4.5)decane-3-carboxylic acid2287272-43-7C14H23NO5
- tert-Butyl N-(8-oxa-1-azaspiro[4.5]decan-3-ylmethyl)carbamate2287275-22-1C14H26N2O3
- 2-{1-[(tert-Butoxy)carbonyl]-8-oxa-1-azaspiro[4.5]decan-3-yl}aceticacid2287286-10-4C15H25NO5
- Methyl8-oxa-1-azaspiro[4.5]decane-3-carboxylatehydrochloride2287318-54-9C10H18ClNO3
- Methyl 8-oxa-1-azaspiro[4.5]decane-3-carboxylate2287270-95-3C10H17NO3
- 1-[(2-Methylpropan-2-yl)oxycarbonyl]-8-oxa-1-azaspiro[4.5]decane-4-carboxylic acid2305253-73-8C14H23NO5
- {8-Oxa-1-azaspiro[4.5]decan-3-yl}methanol2305255-21-2C9H17NO2
- 8-Oxa-1-azaspiro[4.5]decane-4-carboxylic acid hydrochloride2305253-44-3C9H16ClNO3
- 2-(8-Oxa-1-azaspiro[4.5]decan-3-yl)acetic acid, hydrochloride2344679-98-5C10H18ClNO3
- 2-{8-Oxa-1-azaspiro[4.5]decan-3-yl}acetic acid2344679-35-0C10H17NO3
- Methyl 2-{8-oxa-1-azaspiro[4.5]decan-3-yl}acetate hydrochloride2361730-65-4C11H20ClNO3
- Methyl 2-{8-oxa-1-azaspiro[4.5]decan-3-yl}acetate2361730-64-3C11H19NO3
- 3-Methanesulfonyl-8-oxa-1-azaspiro[4.5]decane hydrochloride2375259-98-4C9H18ClNO3S
- 3-Methanesulfonyl-8-oxa-1-azaspiro[4.5]decane2375259-97-3C9H17NO3S
- N-Methyl-N-[2-(8-oxa-1-azaspiro[4.5]decan-1-yl)-2-oxoethyl]prop-2-enamide2361841-50-9C14H22N2O3
- (3R,4S)-8-Oxa-1-azaspiro[4.5]decane-3,4-diol, hydrochloride2377004-56-1C8H16ClNO3
- N-{1-Methyl-8-oxa-1-azaspiro[4.5]decan-3-yl}prop-2-enamide2361657-61-4C12H20N2O2
- 3-Methoxy-8-oxa-1-azaspiro[4.5]decane2503208-43-1C9H17NO2
- 3-(Methylsulfanyl)-8-oxa-1-azaspiro[4.5]decane hydrochloride2551114-72-6C9H18ClNOS
- 3-(Methylsulfanyl)-8-oxa-1-azaspiro[4.5]decane2551114-71-5C9H17NOS
- Imino(methyl){8-oxa-1-azaspiro[4.5]decan-3-yl}-lambda6-sulfanone dihydrochloride2551114-76-0C9H20Cl2N2O2S
Related scaffolds
Same ring framework with different atoms or bond orders
C1CCC2(CC1)OCCO258 chemicals
O=C1NC(=O)C2(CCCCC2)N145 chemicals
C1CCC2(C1)CCNCC221 chemicals
C1COC2(C1)CCNCC219 chemicals
C1CCC2(CC1)CCCC218 chemicals
C1CC2(CCOCC2)CN118 chemicals
C1CCC2(CC1)CCNC218 chemicals
C1CC2(CCN1)CCOC215 chemicals
C1CC2(CCN1)CCNC213 chemicals
C1CNC2(C1)CCNCC211 chemicals
C1CCC2(CC1)NCCO210 chemicals
C1CCC2(CC1)CCCO210 chemicals