Murcko scaffold
1-Oxa-8-azaspiro(4.5)decane scaffold
220 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 10
- Chemicals
- 220
- With full pages
- 19
Scaffold SMILES
C1COC2(C1)CCNCC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 220 chemicals
![8-Ethoxycarbonyl-3-hydroxy-2-methyl-1-oxa-8-azaspiro[4,5]decane chemical structure, C12H21NO4, CAS 123319-31-3](/s/FAGRQKLLMXVQML-UHFFFAOYSA-N.svg)
8-Ethoxycarbonyl-3-hydroxy-2-methyl-1-oxa-8-azaspiro[4,5]decane
CAS 123319-31-3C12H21NO4
![1-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 3-hydroxy-, ethyl ester chemical structure, C11H19NO4, CAS 133382-30-6](/s/UARTZSLRRHJQMX-UHFFFAOYSA-N.svg)
1-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 3-hydroxy-, ethyl ester
CAS 133382-30-6C11H19NO4
![tert-Butyl 3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate chemical structure, C13H22BrNO3, CAS 898157-46-5](/s/OWIBUDVDBOTXOB-UHFFFAOYSA-N.svg)
tert-Butyl 3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS 898157-46-5C13H22BrNO3
![3-Bromo-1-oxa-8-azaspiro[4.5]decane hydrochloride chemical structure, C8H15BrClNO, CAS 1147190-07-5](/s/FJKWULVJSBYVEJ-UHFFFAOYSA-N.svg)
3-Bromo-1-oxa-8-azaspiro[4.5]decane hydrochloride
CAS 1147190-07-5C8H15BrClNO
1-Oxa-8-azaspiro(4.5)decane hydrochloride
CAS 3970-79-4C8H16ClNO
1-Oxa-8-azaspiro(4.5)decane
CAS 176-92-1C8H15NO
![2,2-Dimethyl-1-oxa-8-azaspiro[4.5]decane chemical structure, C10H19NO, CAS 374794-94-2](/s/QLDPRSSIBTVEJA-UHFFFAOYSA-N.svg)
2,2-Dimethyl-1-oxa-8-azaspiro[4.5]decane
CAS 374794-94-2C10H19NO
![tert-Butyl 1-oxa-8-azaspiro[4.5]decane-8-carboxylate chemical structure, C13H23NO3, CAS 374794-89-5](/s/JLIBXBGSIZHAPD-UHFFFAOYSA-N.svg)
tert-Butyl 1-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS 374794-89-5C13H23NO3
![1-Oxa-8-azaspiro[4.5]decane, trifluoroacetate (9CI) chemical structure, C10H16F3NO3, CAS 774224-57-6](/s/OSSNEWDHFCVQNP-UHFFFAOYSA-N.svg)
1-Oxa-8-azaspiro[4.5]decane, trifluoroacetate (9CI)
CAS 774224-57-6C10H16F3NO3
![tert-Butyl 3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate chemical structure, C13H23NO4, CAS 240401-09-6](/s/HCDWHGFENXBNSC-UHFFFAOYSA-N.svg)
tert-Butyl 3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS 240401-09-6C13H23NO4
![1-Oxa-8-azaspiro[4.5]decan-2-ylmethanol chemical structure, C9H17NO2, CAS 1290627-73-4](/s/UJPIFNDLMZGVGO-UHFFFAOYSA-N.svg)
1-Oxa-8-azaspiro[4.5]decan-2-ylmethanol
CAS 1290627-73-4C9H17NO2
![8-Methyl-1-oxa-8-azaspiro[4.5]decan-3-ol--hydrogen chloride (1/1) chemical structure, C9H18ClNO2, CAS 133382-28-2](/s/QOUPYPDQPYZVJW-UHFFFAOYSA-N.svg)
8-Methyl-1-oxa-8-azaspiro[4.5]decan-3-ol--hydrogen chloride (1/1)
CAS 133382-28-2C9H18ClNO2
![1-Oxa-8-azaspiro[4.5]decane-3-carboxylic acid chemical structure, C9H15NO3, CAS 2260932-83-8](/s/JBRKCQQJLWGEKE-UHFFFAOYSA-N.svg)
1-Oxa-8-azaspiro[4.5]decane-3-carboxylic acid
CAS 2260932-83-8C9H15NO3
![tert-Butyl (R)-3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate chemical structure, C13H23NO4, CAS 2201583-40-4](/s/HCDWHGFENXBNSC-SNVBAGLBSA-N.svg)
tert-Butyl (R)-3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS 2201583-40-4C13H23NO4
![tert-Butyl (S)-3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate chemical structure, C13H23NO4, CAS 2239301-11-0](/s/HCDWHGFENXBNSC-JTQLQIEISA-N.svg)
tert-Butyl (S)-3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS 2239301-11-0C13H23NO4
![1-Oxa-8-azaspiro[4.5]decan-3-ol chemical structure, C8H15NO2, CAS 757239-76-2](/s/JQNSUWHWLBLHQL-UHFFFAOYSA-N.svg)
1-Oxa-8-azaspiro[4.5]decan-3-ol
CAS 757239-76-2C8H15NO2
![1-Oxa-8-azaspiro[4.5]decan-4-ol chemical structure, C8H15NO2, CAS 757239-68-2](/s/KUEFHUPQKWILNE-UHFFFAOYSA-N.svg)
1-Oxa-8-azaspiro[4.5]decan-4-ol
CAS 757239-68-2C8H15NO2
![N-((8-(3-Methylbutanoyl)-1-oxa-8-azaspiro[4.5]decan-2-yl)methyl)pivalamide chemical structure, C19H34N2O3, CAS 1061125-48-1](/s/QKWSDFBAXDZDAD-UHFFFAOYSA-N.svg)
N-((8-(3-Methylbutanoyl)-1-oxa-8-azaspiro[4.5]decan-2-yl)methyl)pivalamide
CAS 1061125-48-1C19H34N2O3
![tert-Butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate chemical structure, C13H24N2O3, CAS 1160246-91-2](/s/GBLUNQGZHFQTPW-UHFFFAOYSA-N.svg)
tert-Butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS 1160246-91-2C13H24N2O3
8-((tert-Butoxy)carbonyl)-1-oxa-8-azaspiro(4.5)decane-3-carboxylic acid
CAS 1160246-97-8C14H23NO5
![3-Fluoro-1-oxa-8-azaspiro[4.5]decane chemical structure, C8H14FNO, CAS 1214875-53-2](/s/NWFWQBSPKCCTMW-UHFFFAOYSA-N.svg)
3-Fluoro-1-oxa-8-azaspiro[4.5]decane
CAS 1214875-53-2C8H14FNO
![3,3-Difluoro-1-oxa-8-azaspiro[4.5]decane chemical structure, C8H13F2NO, CAS 1214875-09-8](/s/TXDBSMYUFFCTNM-UHFFFAOYSA-N.svg)
3,3-Difluoro-1-oxa-8-azaspiro[4.5]decane
CAS 1214875-09-8C8H13F2NO
![8-[(tert-Butoxy)carbonyl]-1-oxa-8-azaspiro[4.5]decane-2-carboxylic acid chemical structure, C14H23NO5, CAS 1160246-88-7](/s/RGBNXKRQHVDSGM-UHFFFAOYSA-N.svg)
8-[(tert-Butoxy)carbonyl]-1-oxa-8-azaspiro[4.5]decane-2-carboxylic acid
CAS 1160246-88-7C14H23NO5
![tert-Butyl 2-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate chemical structure, C13H23NO4, CAS 896103-70-1](/s/MTLANSXDLMFWGB-UHFFFAOYSA-N.svg)
tert-Butyl 2-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS 896103-70-1C13H23NO4
- tert-Butyl 3-cyano-1-oxa-8-azaspiro[4.5]decane-8-carboxylate1160246-93-4C14H22N2O3
- tert-Butyl 4-hydroxy-1-oxa-8-azaspiro(4.5)decane-8-carboxylate757239-67-1C13H23NO4
- tert-Butyl 3-allyl-3-methyl-1-oxa-8-azaspiro[4.5]decane-8-carboxylate723288-78-6C17H29NO3
- tert-Butyl 2-(iodomethyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate1373028-07-9C14H24INO3
- 1 suppliers2-(8-((tert-Butoxy)carbonyl)-1-oxa-8-azaspiro(4.5)decan-3-yl)acetic acid1160246-87-6C15H25NO5
- 8-tert-Butyl 2-methyl 1-oxa-8-azaspiro[4.5]decane-2,8-dicarboxylate1160246-95-6C15H25NO5
- 8-Boc-2-(hydroxymethyl)-1-oxa-8-azaspiro[4.5]decane1373028-78-4C14H25NO4
- tert-Butyl 3-(aminomethyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate1160246-96-7C14H26N2O3
- tert-Butyl 2-(aminomethyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate1160246-90-1C14H26N2O3
- 1-Oxa-8-azaspiro[4.5]decane-3-methanol1290625-37-4C9H17NO2
- 1-Oxa-8-azaspiro[4.5]decane-8-sulfonamide4193-56-0C8H16N2O3S
- tert-Butyl 1-oxa-8-azaspiro[4.5]dec-3-ylcarbamate1377187-33-1C13H24N2O3
- Methyl 1-oxa-8-azaspiro[4.5]decane-2-carboxylate hydrochloride1392804-61-3C10H18ClNO3
- Methyl 1-oxa-8-azaspiro[4.5]decane-2-carboxylate1392879-26-3C10H17NO3
- tert-Butyl 8-(2-ethylbutyl)-1-oxa-8-azaspiro[4.5]dec-3-ylcarbamate1439908-06-1C19H36N2O3
- 3-Methoxy-1-oxa-8-azaspiro(4.5)decane hydrochloride1390654-92-8C9H18ClNO2
- tert-Butyl (S)-3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate2387567-25-9C13H24N2O3
- tert-Butyl (R)-3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate2075639-26-6C13H24N2O3
- tert-Butyl (3RS)-3-[(methylsulfonyl)oxy]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate1227473-16-6C14H25NO6S
- 2,2-Dimethyl-1-oxa-8-aza-spiro[4.5]decane hydrochloride1965310-00-2C10H20ClNO
- (8-Methyl-1-oxa-8-azaspiro[4.5]decan-3-yl)methanol1330765-11-1C10H19NO2
- (8-Methyl-1-oxa-8-azaspiro[4.5]decan-2-yl)methanol1330763-53-5C10H19NO2
- 1-Oxa-8-azaspiro[4.5]decan-3-amine1434247-10-5C8H16N2O
- 1-Oxa-8-azaspiro[4.5]decan-3-ylmethanamine1434247-00-3C9H18N2O
Related scaffolds
Same ring framework with different atoms or bond orders
C1CCC2(CC1)OCCO258 chemicals
O=C1NC(=O)C2(CCCCC2)N145 chemicals
C1CCC2(C1)CCNCC221 chemicals
C1CCC2(CC1)CCCC218 chemicals
C1CC2(CCOCC2)CN118 chemicals
C1CCC2(CC1)CCNC218 chemicals
C1CC2(CCN1)CCOC215 chemicals
C1CC2(CCN1)CCNC213 chemicals
C1CNC2(C1)CCNCC211 chemicals
C1CNC2(C1)CCOCC211 chemicals
C1CCC2(CC1)NCCO210 chemicals
C1CCC2(CC1)CCCO210 chemicals