Murcko scaffold
2-Oxa-8-azaspiro(4.5)decane scaffold
169 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 10
- Chemicals
- 169
- With full pages
- 15
Scaffold SMILES
C1CC2(CCN1)CCOC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 169 chemicals
![1,1-Dimethyl-2-oxa-8-azaspiro[4.5]decane chemical structure, C10H19NO, CAS 374794-98-6](/s/VBFWOAOPBSWXNQ-UHFFFAOYSA-N.svg)
1,1-Dimethyl-2-oxa-8-azaspiro[4.5]decane
CAS 374794-98-6C10H19NO
![tert-Butyl 3-hydroxy-2-oxa-8-azaspiro[4.5]decane-8-carboxylate chemical structure, C13H23NO4, CAS 203662-20-8](/s/DIRFZLKSWFXVAK-UHFFFAOYSA-N.svg)
tert-Butyl 3-hydroxy-2-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS 203662-20-8C13H23NO4
![tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate chemical structure, C13H23NO3, CAS 374794-96-4](/s/JHFMRJOXVOCJJQ-UHFFFAOYSA-N.svg)
tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS 374794-96-4C13H23NO3
2-Oxa-8-azaspiro(4.5)decane hydrochloride
CAS 479195-19-2C8H16ClNO
2-Oxa-8-azaspiro(4.5)decane
CAS 176-69-2C8H15NO
3,3-Dimethyl-2-oxa-8-azaspiro(4.5)decane
CAS 374795-01-4C10H19NO
![2-Oxa-8-azaspiro[4.5]decan-4-ol, hydrochloride chemical structure, C8H16ClNO2, CAS 374795-07-0](/s/RXRQFJVKYFXOJJ-UHFFFAOYSA-N.svg)
2-Oxa-8-azaspiro[4.5]decan-4-ol, hydrochloride
CAS 374795-07-0C8H16ClNO2
![2-Oxa-8-azaspiro[4.5]decan-4-ol chemical structure, C8H15NO2, CAS 777049-50-0](/s/TUXFSVNDVGOMQY-UHFFFAOYSA-N.svg)
2-Oxa-8-azaspiro[4.5]decan-4-ol
CAS 777049-50-0C8H15NO2
![tert-Butyl 3-(hydroxymethyl)-2-oxa-8-azaspiro[4.5]decane-8-carboxylate chemical structure, C14H25NO4, CAS 1245649-50-6](/s/ALDMZOAPVQUUIX-UHFFFAOYSA-N.svg)
tert-Butyl 3-(hydroxymethyl)-2-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS 1245649-50-6C14H25NO4
![3-((Methylthio)methyl)-2-oxa-8-azaspiro[4.5]decane chemical structure, C10H19NOS, CAS 1209297-97-1](/s/CQESTZGPIRSWTO-UHFFFAOYSA-N.svg)
3-((Methylthio)methyl)-2-oxa-8-azaspiro[4.5]decane
CAS 1209297-97-1C10H19NOS
![tert-Butyl 3-(Bromomethyl)-2-oxa-8-azaspiro[4.5]decane-8-carboxylate chemical structure, C14H24BrNO3, CAS 1216815-21-2](/s/MMYHBYDKBBFVKS-UHFFFAOYSA-N.svg)
tert-Butyl 3-(Bromomethyl)-2-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS 1216815-21-2C14H24BrNO3
![3-(Methylthiomethyl)-2-oxa-8-azaspiro[4.5]decane hydrochloride chemical structure, C10H20ClNOS, CAS 1263281-42-0](/s/GRDXPGUOWHPCHX-UHFFFAOYSA-N.svg)
3-(Methylthiomethyl)-2-oxa-8-azaspiro[4.5]decane hydrochloride
CAS 1263281-42-0C10H20ClNOS
8-((tert-Butoxy)carbonyl)-2-oxa-8-azaspiro(4.5)decane-3-carboxylic acid
CAS 1160246-86-5C14H23NO5
![3-(Iodomethyl)-2-oxa-8-azaspiro[4.5]decane chemical structure, C9H16INO, CAS 2060032-59-7](/s/AWMKOEBGHORCSG-UHFFFAOYSA-N.svg)
3-(Iodomethyl)-2-oxa-8-azaspiro[4.5]decane
CAS 2060032-59-7C9H16INO
![2-Oxa-8-azaspiro[4.5]decan-3-ylmethanol chemical structure, C9H17NO2, CAS 1824076-74-5](/s/GHDGYXGAYAYPOG-UHFFFAOYSA-N.svg)
2-Oxa-8-azaspiro[4.5]decan-3-ylmethanol
CAS 1824076-74-5C9H17NO2
![3-(Bromomethyl)-2-oxa-8-azaspiro[4.5]decane chemical structure, C9H16BrNO, CAS 2060061-70-1](/s/NGFMYMVGIRFWSW-UHFFFAOYSA-N.svg)
3-(Bromomethyl)-2-oxa-8-azaspiro[4.5]decane
CAS 2060061-70-1C9H16BrNO
![(R)-2-Oxa-8-azaspiro[4.5]decan-4-ol chemical structure, C8H15NO2, CAS 1162654-42-3](/s/TUXFSVNDVGOMQY-ZETCQYMHSA-N.svg)
(R)-2-Oxa-8-azaspiro[4.5]decan-4-ol
CAS 1162654-42-3C8H15NO2
![1,1-Dimethyl-2-oxa-8-azaspiro[4.5]decane hydrochloride chemical structure, C10H20ClNO, CAS 1427425-91-9](/s/ARKAAOPPBJHPNW-UHFFFAOYSA-N.svg)
1,1-Dimethyl-2-oxa-8-azaspiro[4.5]decane hydrochloride
CAS 1427425-91-9C10H20ClNO
![4-Hydroxy-3,3-dimethyl-2-oxa-8-azaspiro[4.5]decane chemical structure, C10H19NO2, CAS 757239-73-9](/s/XFSZJHPPUMVEKA-UHFFFAOYSA-N.svg)
4-Hydroxy-3,3-dimethyl-2-oxa-8-azaspiro[4.5]decane
CAS 757239-73-9C10H19NO2
![tert-Butyl 4-hydroxy-2-oxa-8-azaspiro[4.5]decane-8-carboxylate chemical structure, C13H23NO4, CAS 757239-42-2](/s/NINPBWKLSQKRJE-UHFFFAOYSA-N.svg)
tert-Butyl 4-hydroxy-2-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS 757239-42-2C13H23NO4
![(4S)-2-Oxa-8-azaspiro[4.5]decan-4-ol, hydrochloride chemical structure, C8H16ClNO2, CAS 2387566-56-3](/s/RXRQFJVKYFXOJJ-OGFXRTJISA-N.svg)
(4S)-2-Oxa-8-azaspiro[4.5]decan-4-ol, hydrochloride
CAS 2387566-56-3C8H16ClNO2
![(S)-2-Oxa-8-azaspiro[4.5]decan-4-ol chemical structure, C8H15NO2, CAS 2387566-55-2](/s/TUXFSVNDVGOMQY-SSDOTTSWSA-N.svg)
(S)-2-Oxa-8-azaspiro[4.5]decan-4-ol
CAS 2387566-55-2C8H15NO2
![tert-Butyl 1,1-dimethyl-2-oxa-8-azaspiro[4.5]decane-8-carboxylate chemical structure, C15H27NO3, CAS 1333222-28-8](/s/SDMOPPLAMMWWHF-UHFFFAOYSA-N.svg)
tert-Butyl 1,1-dimethyl-2-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS 1333222-28-8C15H27NO3
tert-Butyl 3-(aminomethyl)-2-oxa-8-azaspiro(4.5)decane-8-carboxylate
CAS 1268520-21-3C14H26N2O3
- 2-Oxa-8-azaspiro[4.5]decane oxalate1588441-03-5C10H17NO5
- tert-Butyl 3-(iodomethyl)-2-oxa-8-azaspiro(4.5)decane-8-carboxylate1250998-93-6C14H24INO3
- 3,3-Dimethyl-2-oxa-8-azaspiro[4.5]decane hydrochloride1379315-59-9C10H20ClNO
- 6-Methyl-2-oxa-8-azaspiro[4.5]decane1427356-57-7C9H17NO
- 1-Methyl-2-oxa-8-azaspiro[4.5]decane1555778-41-0C9H17NO
- tert-Butyl 3-(acetoxymethyl)-2-oxa-8-azaspiro[4.5]decane-8-carboxylate1416372-24-1C16H27NO5
- 2-Oxa-8-azaspiro[4.5]decane hemioxalate1951444-83-9C18H32N2O6
- tert-Butyl (2-oxa-8-azaspiro[4.5]decan-3-ylmethyl)carbamate1657033-43-6C14H26N2O3
- 3-Methyl-2-oxa-8-azaspiro[4.5]decane hydrochloride1657033-36-7C9H18ClNO
- 3-Methyl-2-oxa-8-azaspiro[4.5]decane1657742-07-8C9H17NO
- tert-Butyl 3-(aminomethyl)-2-oxa-8-azaspiro[4.5]decane-8-carboxylate hydrochloride1778734-66-9C14H27ClN2O3
- (3S,4S)-3-Methyl-2-oxa-8-azaspiro[4.5]decan-4-amine1801767-25-8C9H18N2O
- (R)-2-Methyl-N-((S)-2-oxa-8-azaspiro[4.5]decan-4-yl)propane-2-sulfinamide2169224-53-5C12H24N2O2S
- (3R,4S)-tert-Butyl 4-((R)-1,1-dimethylethylsulfinamido)-3-methyl-2-oxa-8-azaspiro[4.5]decane-8-carboxylate1801766-79-9C18H34N2O4S
- (3R,4S)-3-Methyl-2-oxa-8-azaspiro[4.5]decan-4-amine1801767-24-7C9H18N2O
- (3S,4s)-tert-Butyl4-((r)-1,1-dimethylethylsulfinamido)-3-methyl-2-oxa-8-azaspiro[4.5]decane-8-carboxylateC18H34N2O4S
- (3R,4R)-3-Methyl-2-oxa-8-azaspiro[4.5]decan-4-amine hydrochloride2055760-53-5C9H19ClN2O
- (3R,4R)-3-Methyl-2-oxa-8-azaspiro[4.5]decan-4-amine2055760-52-4C9H18N2O
- 1 suppliers(3S,4S)-3-Methyl-2-oxa-8-azaspiro[4.5]decan-4-amine dihydrochloride2055761-19-6C9H20Cl2N2O
- (S)-2-Oxa-8-azaspiro[4.5]decan-4-amine2055760-60-4C8H16N2O
- tert-Butyl (S)-4-(((R)-tert-butylsulfinyl)amino)-2-oxa-8-azaspiro[4.5]decane-8-carboxylate1801766-69-7C17H32N2O4S
- 1 supplierstert-Butyl (3S)-4-hydroxy-3-methyl-2-oxa-8-azaspiro[4.5]decane-8-carboxylate1801766-82-4C14H25NO4
- tert-Butyl (3S,4S)-4-(((R)-tert-butylsulfinyl)amino)-3-methyl-2-oxa-8-azaspiro[4.5]decane-8-carboxylateC18H34N2O4S
- 2-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 4-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]-, 1,1-dimethylethyl ester, (4S)-C17H32N2O4S
Related scaffolds
Same ring framework with different atoms or bond orders
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