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Murcko scaffold

1,4-Dioxaspiro(4.5)decane scaffold

634 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
634
With full pages
58
Scaffold SMILES

C1CCC2(CC1)OCCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,4-Dioxaspiro(4.5)decane page
Murcko scaffold C1CCC2(CC1)OCCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 634 chemicals

1,4-Dioxaspiro(4.5)decane chemical structure, C8H14O2, CAS 177-10-6
1,4-Dioxaspiro(4.5)decane
CAS 177-10-6C8H14O2
(1,4-Dioxaspiro(4.5)decan-2-yl)methanol chemical structure, C9H16O3, CAS 4167-35-5
(1,4-Dioxaspiro(4.5)decan-2-yl)methanol
CAS 4167-35-5C9H16O3
1,4-Dioxaspiro[4.5]decane, 2-methyl- chemical structure, C9H16O2, CAS 4722-68-3
1,4-Dioxaspiro[4.5]decane, 2-methyl-
CAS 4722-68-3C9H16O2
1,4-Dioxaspiro(4.5)decane-2-methanol, carbamate chemical structure, C10H17NO4, CAS 27450-15-3
1,4-Dioxaspiro(4.5)decane-2-methanol, carbamate
CAS 27450-15-3C10H17NO4
Guanadrel chemical structure, C10H19N3O2, CAS 40580-59-4
Guanadrel
CAS 40580-59-4C10H19N3O2
1,4-Dioxaspiro(4.5)decane-3-methanol, 6-methyl- chemical structure, C10H18O3, CAS 63917-43-1
1,4-Dioxaspiro(4.5)decane-3-methanol, 6-methyl-
CAS 63917-43-1C10H18O3
1,4-Dioxaspiro(4.5)decane-3-methanol, 7-methyl- chemical structure, C10H18O3, CAS 63917-44-2
1,4-Dioxaspiro(4.5)decane-3-methanol, 7-methyl-
CAS 63917-44-2C10H18O3
1,4-Dioxaspiro(4.5)decane-3-methanol, 8-methyl- chemical structure, C10H18O3, CAS 63917-45-3
1,4-Dioxaspiro(4.5)decane-3-methanol, 8-methyl-
CAS 63917-45-3C10H18O3
1,4-Dioxaspiro[4.5]decane, 8-(1,1-dimethylethyl)- chemical structure, C12H22O2, CAS 2223-71-4
1,4-Dioxaspiro[4.5]decane, 8-(1,1-dimethylethyl)-
CAS 2223-71-4C12H22O2
Spiroxamine chemical structure, C18H35NO2, CAS 118134-30-8
Spiroxamine
CAS 118134-30-8C18H35NO2
2-(Chloromethyl)-1,4-dioxaspiro[4.5]decane chemical structure, C9H15ClO2, CAS 5503-32-2
2-(Chloromethyl)-1,4-dioxaspiro[4.5]decane
CAS 5503-32-2C9H15ClO2
1,4-Dioxaspiro[4.5]decane, 7,7,9-trimethyl- chemical structure, C11H20O2, CAS 941-29-7
1,4-Dioxaspiro[4.5]decane, 7,7,9-trimethyl-
CAS 941-29-7C11H20O2
1,4-Dioxaspiro(4.5)decane, 8-(1,1-dimethylethyl)-2-methyl- chemical structure, C13H24O2, CAS 62406-83-1
1,4-Dioxaspiro(4.5)decane, 8-(1,1-dimethylethyl)-2-methyl-
CAS 62406-83-1C13H24O2
2,9-Dimethyl-6-(1-methylethyl)-1,4-dioxaspiro[4.5]decane chemical structure, C13H24O2, CAS 33889-48-4
2,9-Dimethyl-6-(1-methylethyl)-1,4-dioxaspiro[4.5]decane
CAS 33889-48-4C13H24O2
2,3-Dimethyl-1,4-dioxaspiro[4.5]decane chemical structure, C10H18O2, CAS 5413-48-9
2,3-Dimethyl-1,4-dioxaspiro[4.5]decane
CAS 5413-48-9C10H18O2
2,8-Dimethyl-1,4-dioxaspiro[4.5]decane chemical structure, C10H18O2, CAS 5406-40-6
2,8-Dimethyl-1,4-dioxaspiro[4.5]decane
CAS 5406-40-6C10H18O2
2,3,8-Trimethyl-1,4-dioxaspiro[4.5]decane chemical structure, C11H20O2, CAS 5406-45-1
2,3,8-Trimethyl-1,4-dioxaspiro[4.5]decane
CAS 5406-45-1C11H20O2
1,4-Dioxaspiro[4.5]decan-3-ylmethyl acetate chemical structure, C11H18O4, CAS 82372-19-8
1,4-Dioxaspiro[4.5]decan-3-ylmethyl acetate
CAS 82372-19-8C11H18O4
4-(1,4-Dioxaspiro[4.5]dec-2-yl)butan-1-ol chemical structure, C12H22O3, CAS 4994-41-6
4-(1,4-Dioxaspiro[4.5]dec-2-yl)butan-1-ol
CAS 4994-41-6C12H22O3
1,4-Dioxaspiro[4.5]decan-7-ylmethanamine chemical structure, C9H17NO2, CAS 7143-13-7
1,4-Dioxaspiro[4.5]decan-7-ylmethanamine
CAS 7143-13-7C9H17NO2
1-(1,4-Dioxaspiro[4.5]decan-6-yl)-N,N-dimethylmethanamine chemical structure, C11H21NO2, CAS 6309-23-5
1-(1,4-Dioxaspiro[4.5]decan-6-yl)-N,N-dimethylmethanamine
CAS 6309-23-5C11H21NO2
7,9,9-Trimethyl-1,4-dioxaspiro[4.5]decane-7-carbonitrile chemical structure, C12H19NO2, CAS 6309-26-8
7,9,9-Trimethyl-1,4-dioxaspiro[4.5]decane-7-carbonitrile
CAS 6309-26-8C12H19NO2
1-(7,9,9-Trimethyl-1,4-dioxaspiro[4.5]dec-7-yl)methanamine chemical structure, C12H23NO2, CAS 6309-29-1
1-(7,9,9-Trimethyl-1,4-dioxaspiro[4.5]dec-7-yl)methanamine
CAS 6309-29-1C12H23NO2
3-(Ethoxymethyl)-1,4-dioxaspiro[4.5]decane chemical structure, C11H20O3, CAS 6339-76-0
3-(Ethoxymethyl)-1,4-dioxaspiro[4.5]decane
CAS 6339-76-0C11H20O3