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Murcko scaffold

Ring system with 3 rings and 25 atoms

122 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
122
With full pages
10
Scaffold SMILES

O=C(CCN1C(=O)C(=Cc2ccccc2)SC1=S)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCN1C(=O)C(=Cc2ccccc2)SC1=S)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 122 chemicals

3-[(5Z)-5-Benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(3-bromophenyl)propanamide chemical structure, C19H15BrN2O2S2, CAS 303055-92-7
3-[(5Z)-5-Benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(3-bromophenyl)propanamide
CAS 303055-92-7C19H15BrN2O2S2
N-(4-Hydroxyphenyl)-3-[(5E)-5-[(4-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanamide chemical structure, C20H18N2O4S2, CAS 313960-60-0
N-(4-Hydroxyphenyl)-3-[(5E)-5-[(4-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanamide
CAS 313960-60-0C20H18N2O4S2
3-[(5Z)-5-[(4-Ethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(3-methoxyphenyl)propanamide chemical structure, C22H22N2O4S2, CAS 361200-15-9
3-[(5Z)-5-[(4-Ethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(3-methoxyphenyl)propanamide
CAS 361200-15-9C22H22N2O4S2
N-(4-Fluorophenyl)-3-[5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanamide chemical structure, C20H17FN2O2S2, CAS 6588-85-8
N-(4-Fluorophenyl)-3-[5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanamide
CAS 6588-85-8C20H17FN2O2S2
3-[(5Z)-5-[(4-Ethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-[2-(trifluoromethyl)phenyl]propanamide chemical structure, C22H19F3N2O3S2, CAS 307546-29-8
3-[(5Z)-5-[(4-Ethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-[2-(trifluoromethyl)phenyl]propanamide
CAS 307546-29-8C22H19F3N2O3S2
3-[(5Z)-5-[(3,4-Dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(4-fluorophenyl)propanamide chemical structure, C21H19FN2O4S2, CAS 403829-90-3
3-[(5Z)-5-[(3,4-Dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(4-fluorophenyl)propanamide
CAS 403829-90-3C21H19FN2O4S2
N-(5-Chloro-2-hydroxyphenyl)-3-[(5Z)-5-[(2-chlorophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanamide chemical structure, C19H14Cl2N2O3S2, CAS 6598-32-9
N-(5-Chloro-2-hydroxyphenyl)-3-[(5Z)-5-[(2-chlorophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanamide
CAS 6598-32-9C19H14Cl2N2O3S2
3-({3-[(5Z)-5-(2-Chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoyl}amino)benzoic acid chemical structure, C20H15ClN2O4S2, CAS 6603-74-3
3-({3-[(5Z)-5-(2-Chlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoyl}amino)benzoic acid
CAS 6603-74-3C20H15ClN2O4S2
N-(2,3-Dimethylphenyl)-3-[5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanamide chemical structure, C22H22N2O2S2, CAS 6609-05-8
N-(2,3-Dimethylphenyl)-3-[5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanamide
CAS 6609-05-8C22H22N2O2S2
3-({3-[5-(4-Methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoyl}amino)benzoic acid chemical structure, C21H18N2O4S2, CAS 6615-95-8
3-({3-[5-(4-Methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoyl}amino)benzoic acid
CAS 6615-95-8C21H18N2O4S2
N-(3-Fluorophenyl)-3-[5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanamide chemical structure, C20H17FN2O2S2, CAS 6618-66-2
N-(3-Fluorophenyl)-3-[5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanamide
CAS 6618-66-2C20H17FN2O2S2
3-[(5Z)-5-[(3,4-Dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(3-fluorophenyl)propanamide chemical structure, C21H19FN2O4S2, CAS 425652-69-3
3-[(5Z)-5-[(3,4-Dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(3-fluorophenyl)propanamide
CAS 425652-69-3C21H19FN2O4S2
N-(5-Chloro-2-hydroxyphenyl)-3-[(5Z)-5-[(4-ethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanamide chemical structure, C21H19ClN2O4S2, CAS 307546-30-1
N-(5-Chloro-2-hydroxyphenyl)-3-[(5Z)-5-[(4-ethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanamide
CAS 307546-30-1C21H19ClN2O4S2
N-(5-Chloro-2-hydroxyphenyl)-3-[(5Z)-5-[(3,4-dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanamide chemical structure, C21H19ClN2O5S2, CAS 426236-91-1
N-(5-Chloro-2-hydroxyphenyl)-3-[(5Z)-5-[(3,4-dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanamide
CAS 426236-91-1C21H19ClN2O5S2
N-(4-Chlorophenyl)-3-[(5Z)-5-[(4-ethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanamide chemical structure, C21H19ClN2O3S2, CAS 361200-17-1
N-(4-Chlorophenyl)-3-[(5Z)-5-[(4-ethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanamide
CAS 361200-17-1C21H19ClN2O3S2
(Z)-N-(4-Hydroxyphenyl)-3-(5-(4-methylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanamide chemical structure, C20H18N2O3S2, CAS 300827-11-6
(Z)-N-(4-Hydroxyphenyl)-3-(5-(4-methylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanamide
CAS 300827-11-6C20H18N2O3S2
(Z)-N-(3-Hydroxyphenyl)-3-(5-(4-methylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanamide chemical structure, C20H18N2O3S2, CAS 304674-59-7
(Z)-N-(3-Hydroxyphenyl)-3-(5-(4-methylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanamide
CAS 304674-59-7C20H18N2O3S2
N-(3-Methoxyphenyl)-3-[(5E)-5-[(3-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanamide chemical structure, C21H20N2O4S2, CAS 304674-57-5
N-(3-Methoxyphenyl)-3-[(5E)-5-[(3-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanamide
CAS 304674-57-5C21H20N2O4S2
(Z)-3-(5-(4-Methylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-N-(m-tolyl)propanamide chemical structure, C21H20N2O2S2, CAS 301158-30-5
(Z)-3-(5-(4-Methylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-N-(m-tolyl)propanamide
CAS 301158-30-5C21H20N2O2S2
(Z)-N-(3-Methoxyphenyl)-3-(5-(4-methylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanamide chemical structure, C21H20N2O3S2, CAS 301158-31-6
(Z)-N-(3-Methoxyphenyl)-3-(5-(4-methylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanamide
CAS 301158-31-6C21H20N2O3S2
(Z)-N-(3-Hydroxyphenyl)-3-(5-(3-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanamide chemical structure, C20H18N2O4S2, CAS 303056-01-1
(Z)-N-(3-Hydroxyphenyl)-3-(5-(3-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanamide
CAS 303056-01-1C20H18N2O4S2
N-(4-Hydroxyphenyl)-3-[(5E)-5-(3-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanamide chemical structure, C20H18N2O4S2, CAS 299952-74-2
N-(4-Hydroxyphenyl)-3-[(5E)-5-(3-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanamide
CAS 299952-74-2C20H18N2O4S2
N-(4-Bromophenyl)-3-[(5Z)-5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanamide chemical structure, C20H17BrN2O2S2, CAS 300827-09-2
N-(4-Bromophenyl)-3-[(5Z)-5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanamide
CAS 300827-09-2C20H17BrN2O2S2
3-[(5Z)-5-[(4-Ethylphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(3-fluorophenyl)propanamide chemical structure, C21H19FN2O2S2, CAS 356572-56-0
3-[(5Z)-5-[(4-Ethylphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(3-fluorophenyl)propanamide
CAS 356572-56-0C21H19FN2O2S2