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Murcko scaffold

Ring system with 3 rings and 23 atoms

77 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 23
Chemicals: 77
With full pages: 7

Scaffold SMILES

O=C(C=Cc1ccccc1)Nc1ncc(Cc2ccccc2)s1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C=Cc1ccccc1)Nc1ncc(Cc2ccccc2)s1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 77 chemicals

(2E)-N-[5-(3-Methylbenzyl)-1,3-thiazol-2-yl]-3-phenylprop-2-enamide chemical structure, C20H18N2OS, CAS 304895-53-2

(2E)-N-[5-(3-Methylbenzyl)-1,3-thiazol-2-yl]-3-phenylprop-2-enamide

CAS 304895-53-2C₂₀H₁₈N₂OS

(2E)-N-[5-(4-Methylbenzyl)-1,3-thiazol-2-yl]-3-phenylprop-2-enamide chemical structure, C20H18N2OS, CAS 304895-54-3

(2E)-N-[5-(4-Methylbenzyl)-1,3-thiazol-2-yl]-3-phenylprop-2-enamide

CAS 304895-54-3C₂₀H₁₈N₂OS

(2E)-N-(5-Benzyl-1,3-thiazol-2-yl)-3-phenylprop-2-enamide chemical structure, C19H16N2OS, CAS 301176-80-7

(2E)-N-(5-Benzyl-1,3-thiazol-2-yl)-3-phenylprop-2-enamide

CAS 301176-80-7C₁₉H₁₆N₂OS

(E)-3-(2-Chlorophenyl)-N-[5-[(3-methylphenyl)methyl]-1,3-thiazol-2-yl]prop-2-enamide chemical structure, C20H17ClN2OS, CAS 304895-60-1

(E)-3-(2-Chlorophenyl)-N-[5-[(3-methylphenyl)methyl]-1,3-thiazol-2-yl]prop-2-enamide

CAS 304895-60-1C₂₀H₁₇ClN₂OS

(2E)-3-Phenyl-N-{5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl}prop-2-enamide chemical structure, C20H15F3N2OS, CAS 292057-05-7

(2E)-3-Phenyl-N-{5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl}prop-2-enamide

CAS 292057-05-7C₂₀H₁₅F₃N₂OS

(E)-3-(2-Chlorophenyl)-N-[5-[(2-chlorophenyl)methyl]-1,3-thiazol-2-yl]prop-2-enamide chemical structure, C19H14Cl2N2OS, CAS 304895-59-8

(E)-3-(2-Chlorophenyl)-N-[5-[(2-chlorophenyl)methyl]-1,3-thiazol-2-yl]prop-2-enamide

CAS 304895-59-8C₁₉H₁₄Cl₂N₂OS

(E)-N-[5-[(3-Chlorophenyl)methyl]-1,3-thiazol-2-yl]-3-(3-methylphenyl)prop-2-enamide chemical structure, C20H17ClN2OS, CAS 304895-69-0

(E)-N-[5-[(3-Chlorophenyl)methyl]-1,3-thiazol-2-yl]-3-(3-methylphenyl)prop-2-enamide

CAS 304895-69-0C₂₀H₁₇ClN₂OS

(E)-3-(4-Methoxyphenyl)-N-[5-[(3-methylphenyl)methyl]-1,3-thiazol-2-yl]prop-2-enamide chemical structure, C21H20N2O2S, CAS 304895-75-8

(E)-3-(4-Methoxyphenyl)-N-[5-[(3-methylphenyl)methyl]-1,3-thiazol-2-yl]prop-2-enamide

CAS 304895-75-8C₂₁H₂₀N₂O₂S

(E)-N-[5-[(4-Bromophenyl)methyl]-1,3-thiazol-2-yl]-3-(4-methoxyphenyl)prop-2-enamide chemical structure, C20H17BrN2O2S, CAS 292056-85-0

(E)-N-[5-[(4-Bromophenyl)methyl]-1,3-thiazol-2-yl]-3-(4-methoxyphenyl)prop-2-enamide

CAS 292056-85-0C₂₀H₁₇BrN₂O₂S

3-(4-Methoxyphenyl)-N-(5-(3-(trifluoromethyl)benzyl)thiazol-2-yl)acrylamide chemical structure, C21H17F3N2O2S, CAS 304895-80-5

3-(4-Methoxyphenyl)-N-(5-(3-(trifluoromethyl)benzyl)thiazol-2-yl)acrylamide

CAS 304895-80-5C₂₁H₁₇F₃N₂O₂S

(E)-3-(3,4-Dichlorophenyl)-N-[5-[(3-methylphenyl)methyl]-1,3-thiazol-2-yl]prop-2-enamide chemical structure, C20H16Cl2N2OS, CAS 292056-99-6

(E)-3-(3,4-Dichlorophenyl)-N-[5-[(3-methylphenyl)methyl]-1,3-thiazol-2-yl]prop-2-enamide

CAS 292056-99-6C₂₀H₁₆Cl₂N₂OS

(2E)-3-(2,5-Dichlorophenyl)-N-[5-(3-methylbenzyl)-1,3-thiazol-2-yl]prop-2-enamide chemical structure, C20H16Cl2N2OS, CAS 304895-92-9

(2E)-3-(2,5-Dichlorophenyl)-N-[5-(3-methylbenzyl)-1,3-thiazol-2-yl]prop-2-enamide

CAS 304895-92-9C₂₀H₁₆Cl₂N₂OS

N-[5-(3-Chloro-benzyl)-thiazol-2-yl]-3-(3-trifluoromethyl-phenyl)-acrylamide chemical structure, C20H14ClF3N2OS, CAS 292056-88-3

N-[5-(3-Chloro-benzyl)-thiazol-2-yl]-3-(3-trifluoromethyl-phenyl)-acrylamide

CAS 292056-88-3C₂₀H₁₄ClF₃N₂OS

(Z)-N-(5-(3-Chlorobenzyl)thiazol-2-yl)-2-cyano-3-(3,4-dimethoxyphenyl)acrylamide chemical structure, C22H18ClN3O3S, CAS 307541-93-1

(Z)-N-(5-(3-Chlorobenzyl)thiazol-2-yl)-2-cyano-3-(3,4-dimethoxyphenyl)acrylamide

CAS 307541-93-1C₂₂H₁₈ClN₃O₃S

(Z)-N-(5-(4-Bromobenzyl)thiazol-2-yl)-2-cyano-3-(4-methoxyphenyl)acrylamide chemical structure, C21H16BrN3O2S, CAS 469870-85-7

(Z)-N-(5-(4-Bromobenzyl)thiazol-2-yl)-2-cyano-3-(4-methoxyphenyl)acrylamide

CAS 469870-85-7C₂₁H₁₆BrN₃O₂S

(Z)-N-(5-(4-Bromobenzyl)thiazol-2-yl)-2-cyano-3-(3,4-dimethoxyphenyl)acrylamide chemical structure, C22H18BrN3O3S, CAS 469870-86-8

(Z)-N-(5-(4-Bromobenzyl)thiazol-2-yl)-2-cyano-3-(3,4-dimethoxyphenyl)acrylamide

CAS 469870-86-8C₂₂H₁₈BrN₃O₃S

(2E)-3-(4-Chlorophenyl)-N-[5-(4-fluorobenzyl)-1,3-thiazol-2-yl]-2-propenamide chemical structure, C19H14ClFN2OS, CAS 292057-18-2

(2E)-3-(4-Chlorophenyl)-N-[5-(4-fluorobenzyl)-1,3-thiazol-2-yl]-2-propenamide

CAS 292057-18-2C₁₉H₁₄ClFN₂OS

(2E)-N-[5-(4-Fluorobenzyl)-1,3-thiazol-2-yl]-3-(4-fluorophenyl)prop-2-enamide chemical structure, C19H14F2N2OS, CAS 327062-24-8

(2E)-N-[5-(4-Fluorobenzyl)-1,3-thiazol-2-yl]-3-(4-fluorophenyl)prop-2-enamide

CAS 327062-24-8C₁₉H₁₄F₂N₂OS

(2E)-N-(5-Benzyl-1,3-thiazol-2-yl)-2-cyano-3-(4-methoxyphenyl)prop-2-enamide chemical structure, C21H17N3O2S, CAS 468767-51-3

(2E)-N-(5-Benzyl-1,3-thiazol-2-yl)-2-cyano-3-(4-methoxyphenyl)prop-2-enamide

CAS 468767-51-3C₂₁H₁₇N₃O₂S

(E)-N-(5-Benzylthiazol-2-yl)-2-cyano-3-(4-fluorophenyl)acrylamide chemical structure, C20H14FN3OS, CAS 468767-57-9

(E)-N-(5-Benzylthiazol-2-yl)-2-cyano-3-(4-fluorophenyl)acrylamide

CAS 468767-57-9C₂₀H₁₄FN₃OS

(E)-N-(5-(2-Chlorobenzyl)thiazol-2-yl)-2-cyano-3-(4-hydroxy-3-methoxyphenyl)acrylamide chemical structure, C21H16ClN3O3S, CAS 468768-45-8

(E)-N-(5-(2-Chlorobenzyl)thiazol-2-yl)-2-cyano-3-(4-hydroxy-3-methoxyphenyl)acrylamide

CAS 468768-45-8C₂₁H₁₆ClN₃O₃S

(E)-2-Cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide chemical structure, C21H16FN3OS, CAS 468769-36-0

(E)-2-Cyano-N-(5-(4-fluorobenzyl)thiazol-2-yl)-3-(o-tolyl)acrylamide

CAS 468769-36-0C₂₁H₁₆FN₃OS

(2E)-2-Cyano-3-(4-fluorophenyl)-N-[5-(4-methylbenzyl)-1,3-thiazol-2-yl]prop-2-enamide chemical structure, C21H16FN3OS, CAS 468771-19-9

(2E)-2-Cyano-3-(4-fluorophenyl)-N-[5-(4-methylbenzyl)-1,3-thiazol-2-yl]prop-2-enamide

CAS 468771-19-9C₂₁H₁₆FN₃OS

(2E)-N-[5-(4-Methoxybenzyl)-1,3-thiazol-2-yl]-3-(4-nitrophenyl)prop-2-enamide chemical structure, C20H17N3O4S, CAS 315241-29-3

(2E)-N-[5-(4-Methoxybenzyl)-1,3-thiazol-2-yl]-3-(4-nitrophenyl)prop-2-enamide

CAS 315241-29-3C₂₀H₁₇N₃O₄S