Murcko scaffold
Ring system with 3 rings and 23 atoms
68 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 23
- Chemicals
- 68
- With full pages
- 5
Scaffold SMILES
O=C(COc1ccccc1)Nc1ncc(Cc2ccccc2)s1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 68 chemicals
![2-(4-Chlorophenoxy)-N-[5-[(2-chlorophenyl)methyl]-1,3-thiazol-2-yl]acetamide chemical structure, C18H14Cl2N2O2S, CAS 304895-97-4](/s/JCJAJPXVULIKNS-UHFFFAOYSA-N.svg)
2-(4-Chlorophenoxy)-N-[5-[(2-chlorophenyl)methyl]-1,3-thiazol-2-yl]acetamide
CAS 304895-97-4C18H14Cl2N2O2S
2-(4-Chlorophenoxy)-N-(5-(3-methylbenzyl)-1,3-thiazol-2-yl)acetamide
CAS 303093-71-2C19H17ClN2O2S
2-(4-Chlorophenoxy)-N-(5-(3,4-dichlorobenzyl)-1,3-thiazol-2-yl)acetamide
CAS 301176-42-1C18H13Cl3N2O2S
![N-{5-[(2-Chlorophenyl)methyl]-1,3-thiazol-2-YL}-2-(4-methylphenoxy)acetamide chemical structure, C19H17ClN2O2S, CAS 301176-01-2](/s/BZAXOUQDRKBYID-UHFFFAOYSA-N.svg)
N-{5-[(2-Chlorophenyl)methyl]-1,3-thiazol-2-YL}-2-(4-methylphenoxy)acetamide
CAS 301176-01-2C19H17ClN2O2S
![N-{5-[(3-Chlorophenyl)methyl]-1,3-thiazol-2-YL}-2-(4-methylphenoxy)acetamide chemical structure, C19H17ClN2O2S, CAS 301176-02-3](/s/WIECEVKAWXJGDL-UHFFFAOYSA-N.svg)
N-{5-[(3-Chlorophenyl)methyl]-1,3-thiazol-2-YL}-2-(4-methylphenoxy)acetamide
CAS 301176-02-3C19H17ClN2O2S
N-(5-(4-Fluorobenzyl)thiazol-2-yl)-2-(p-tolyloxy)acetamide
CAS 301176-06-7C19H17FN2O2S
![N-{5-[(3-Chlorophenyl)methyl]-1,3-thiazol-2-YL}-2-(3-methylphenoxy)acetamide chemical structure, C19H17ClN2O2S, CAS 301176-10-3](/s/LAKZCFHPYXZUEK-UHFFFAOYSA-N.svg)
N-{5-[(3-Chlorophenyl)methyl]-1,3-thiazol-2-YL}-2-(3-methylphenoxy)acetamide
CAS 301176-10-3C19H17ClN2O2S
![N-{5-[(4-Bromophenyl)methyl]-1,3-thiazol-2-YL}-2-(2-methylphenoxy)acetamide chemical structure, C19H17BrN2O2S, CAS 301176-22-7](/s/JTDJLNUBRJYKLR-UHFFFAOYSA-N.svg)
N-{5-[(4-Bromophenyl)methyl]-1,3-thiazol-2-YL}-2-(2-methylphenoxy)acetamide
CAS 301176-22-7C19H17BrN2O2S
![2-(2-Chlorophenoxy)-N-{5-[(3-methylphenyl)methyl]-1,3-thiazol-2-YL}acetamide chemical structure, C19H17ClN2O2S, CAS 301176-31-8](/s/KIBYTEMILAPBMD-UHFFFAOYSA-N.svg)
2-(2-Chlorophenoxy)-N-{5-[(3-methylphenyl)methyl]-1,3-thiazol-2-YL}acetamide
CAS 301176-31-8C19H17ClN2O2S
2-(2-Chlorophenoxy)-N-(5-(4-methoxybenzyl)thiazol-2-yl)acetamide
CAS 301176-33-0C19H17ClN2O3S
![2-(2-Chlorophenoxy)-N-[5-[(4-fluorophenyl)methyl]-1,3-thiazol-2-yl]acetamide chemical structure, C18H14ClFN2O2S, CAS 301176-34-1](/s/JSQVBOGWUVBQKL-UHFFFAOYSA-N.svg)
2-(2-Chlorophenoxy)-N-[5-[(4-fluorophenyl)methyl]-1,3-thiazol-2-yl]acetamide
CAS 301176-34-1C18H14ClFN2O2S
![N-{5-[(2-Chlorophenyl)methyl]-1,3-thiazol-2-YL}-2-(2-methoxyphenoxy)acetamide chemical structure, C19H17ClN2O3S, CAS 301176-45-4](/s/YARGWRQRQRKJNX-UHFFFAOYSA-N.svg)
N-{5-[(2-Chlorophenyl)methyl]-1,3-thiazol-2-YL}-2-(2-methoxyphenoxy)acetamide
CAS 301176-45-4C19H17ClN2O3S
![N-{5-[(4-Chlorophenyl)methyl]-1,3-thiazol-2-YL}-2-(2-methoxyphenoxy)acetamide chemical structure, C19H17ClN2O3S, CAS 301176-47-6](/s/QKBSLRHRNJKOTE-UHFFFAOYSA-N.svg)
N-{5-[(4-Chlorophenyl)methyl]-1,3-thiazol-2-YL}-2-(2-methoxyphenoxy)acetamide
CAS 301176-47-6C19H17ClN2O3S
![2-(2-Methoxyphenoxy)-N-{5-[(4-methylphenyl)methyl]-1,3-thiazol-2-YL}acetamide chemical structure, C20H20N2O3S, CAS 301176-48-7](/s/NSODFEZUBXBIGE-UHFFFAOYSA-N.svg)
2-(2-Methoxyphenoxy)-N-{5-[(4-methylphenyl)methyl]-1,3-thiazol-2-YL}acetamide
CAS 301176-48-7C20H20N2O3S
![N-[5-[(2,5-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-2-(2-methoxyphenoxy)acetamide chemical structure, C19H16Cl2N2O3S, CAS 301176-49-8](/s/XACMBWXHGKUHLU-UHFFFAOYSA-N.svg)
N-[5-[(2,5-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-2-(2-methoxyphenoxy)acetamide
CAS 301176-49-8C19H16Cl2N2O3S
![N-{5-[(3,4-Dichlorophenyl)methyl]-1,3-thiazol-2-YL}-2-(2-methoxyphenoxy)acetamide chemical structure, C19H16Cl2N2O3S, CAS 301176-51-2](/s/JODHFVHAZDJDLC-UHFFFAOYSA-N.svg)
N-{5-[(3,4-Dichlorophenyl)methyl]-1,3-thiazol-2-YL}-2-(2-methoxyphenoxy)acetamide
CAS 301176-51-2C19H16Cl2N2O3S
![N-{5-[(4-Bromophenyl)methyl]-1,3-thiazol-2-YL}-2-(2-methoxyphenoxy)acetamide chemical structure, C19H17BrN2O3S, CAS 301176-54-5](/s/GEMZPEUMGBPVTO-UHFFFAOYSA-N.svg)
N-{5-[(4-Bromophenyl)methyl]-1,3-thiazol-2-YL}-2-(2-methoxyphenoxy)acetamide
CAS 301176-54-5C19H17BrN2O3S
N-(5-(2-Chlorobenzyl)thiazol-2-yl)-2-(4-methoxyphenoxy)acetamide
CAS 301176-55-6C19H17ClN2O3S
![2-(4-Methoxyphenoxy)-N-[5-(3-methylbenzyl)-1,3-thiazol-2-yl]acetamide chemical structure, C20H20N2O3S, CAS 450361-41-8](/s/MJCSJUVGMSWMFN-UHFFFAOYSA-N.svg)
2-(4-Methoxyphenoxy)-N-[5-(3-methylbenzyl)-1,3-thiazol-2-yl]acetamide
CAS 450361-41-8C20H20N2O3S
![N-[5-(4-Methoxybenzyl)-1,3-thiazol-2-yl]-2-(4-methoxyphenoxy)acetamide chemical structure, C20H20N2O4S, CAS 450361-45-2](/s/BYPVDKZTZQMBLA-UHFFFAOYSA-N.svg)
N-[5-(4-Methoxybenzyl)-1,3-thiazol-2-yl]-2-(4-methoxyphenoxy)acetamide
CAS 450361-45-2C20H20N2O4S
![N-{5-[(2-Chlorophenyl)methyl]-1,3-thiazol-2-YL}-2-[3-(trifluoromethyl)phenoxy]acetamide chemical structure, C19H14ClF3N2O2S, CAS 301176-63-6](/s/AEMGYILRNIECEY-UHFFFAOYSA-N.svg)
N-{5-[(2-Chlorophenyl)methyl]-1,3-thiazol-2-YL}-2-[3-(trifluoromethyl)phenoxy]acetamide
CAS 301176-63-6C19H14ClF3N2O2S
![N-[5-(4-Chloro-benzyl)-thiazol-2-yl]-2-(3-trifluoromethyl-phenoxy)-acetamide chemical structure, C19H14ClF3N2O2S, CAS 301176-64-7](/s/SJMNAUYURPUXKY-UHFFFAOYSA-N.svg)
N-[5-(4-Chloro-benzyl)-thiazol-2-yl]-2-(3-trifluoromethyl-phenoxy)-acetamide
CAS 301176-64-7C19H14ClF3N2O2S
N-(5-(4-Methoxybenzyl)thiazol-2-yl)-2-(3-(trifluoromethyl)phenoxy)acetamide
CAS 301176-67-0C20H17F3N2O3S
![N-[5-(4-Fluorobenzyl)-1,3-thiazol-2-yl]-2-[3-(trifluoromethyl)phenoxy]acetamide chemical structure, C19H14F4N2O2S, CAS 301176-69-2](/s/DLZIOTKLKOAGRP-UHFFFAOYSA-N.svg)
N-[5-(4-Fluorobenzyl)-1,3-thiazol-2-yl]-2-[3-(trifluoromethyl)phenoxy]acetamide
CAS 301176-69-2C19H14F4N2O2S
- N-(5-Benzyl-1,3-thiazol-2-yl)-2-(4-methoxyphenoxy)acetamide450362-33-1C19H18N2O3S
- N-[5-(4-Fluorobenzyl)-1,3-thiazol-2-yl]-2-(2-methylphenoxy)acetamide301176-21-6C19H17FN2O2S
- N-(5-(2,4-Dichlorobenzyl)thiazol-2-yl)-2-(o-tolyloxy)acetamide314258-19-0C19H16Cl2N2O2S
- N-(5-(4-Methoxybenzyl)thiazol-2-yl)-2-(m-tolyloxy)acetamide301176-14-7C20H20N2O3S
- 2-(2-Methoxyphenoxy)-N-{5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl}acetamide301176-44-3C20H17F3N2O3S
- 2-(2-Methylphenoxy)-N-{5-[(4-methylphenyl)methyl]-1,3-thiazol-2-YL}acetamide301176-20-5C20H20N2O2S
- 2-(4-Methoxyphenoxy)-N-(5-(3-(trifluoromethyl)benzyl)thiazol-2-yl)acetamide301176-61-4C20H17F3N2O3S
- 2-(m-Tolyloxy)-N-(5-(3-(trifluoromethyl)benzyl)thiazol-2-yl)acetamide301176-08-9C20H17F3N2O2S
- 2-(4-Bromophenoxy)-N-[5-(2,5-dichlorobenzyl)-1,3-thiazol-2-yl]acetamide327063-06-9C18H13BrCl2N2O2S
- 2-(4-Bromophenoxy)-N-[5-(4-fluorobenzyl)-1,3-thiazol-2-yl]acetamide327063-08-1C18H14BrFN2O2S
- 2-Phenoxy-N-(5-(3-(trifluoromethyl)benzyl)-1,3-thiazol-2-yl)acetamide303093-70-1C19H15F3N2O2S
- 2-(3,4-Dimethylphenoxy)-N-[5-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl]acetamide831212-71-6C21H19F3N2O2S
- N-(5-Benzyl-1,3-thiazol-2-yl)-2-(3,4-dimethylphenoxy)acetamide831233-05-7C20H20N2O2S
- 2-(4-Bromophenoxy)-N-[5-(3,4-dichlorobenzyl)-1,3-thiazol-2-yl]acetamide327063-07-0C18H13BrCl2N2O2S
- N-{5-[(4-Chlorophenyl)methyl]-1,3-thiazol-2-YL}-2-(3-methylphenoxy)acetamide301176-12-5C19H17ClN2O2S
- N-{5-[(4-Chlorophenyl)methyl]-1,3-thiazol-2-YL}-2-(2-methylphenoxy)acetamide301176-19-2C19H17ClN2O2S
- N-[5-(2,4-Dichlorobenzyl)-1,3-thiazol-2-yl]-2-(3-methylphenoxy)acetamide314258-20-3C19H16Cl2N2O2S
- 2-(3-Methylphenoxy)-N-{5-[(3-methylphenyl)methyl]-1,3-thiazol-2-YL}acetamide301176-11-4C20H20N2O2S
- 2-(2-Chlorophenoxy)-N-[5-[(3,4-dichlorophenyl)methyl]-1,3-thiazol-2-yl]acetamide327063-02-5C18H13Cl3N2O2S
- N-{5-[(4-Methylphenyl)methyl]-1,3-thiazol-2-YL}-2-[3-(trifluoromethyl)phenoxy]acetamide301176-65-8C20H17F3N2O2S
- 2-(4-Methylphenoxy)-N-{5-[(3-methylphenyl)methyl]-1,3-thiazol-2-YL}acetamide301176-03-4C20H20N2O2S
- 2-(4-Chlorophenoxy)-N-{5-[(4-methylphenyl)methyl]-1,3-thiazol-2-YL}acetamide292057-17-1C19H17ClN2O2S
- N-[5-(2,5-Dichlorobenzyl)-1,3-thiazol-2-yl]-2-(4-methylphenoxy)acetamide301176-05-6C19H16Cl2N2O2S
- N-[5-(4-Chlorobenzyl)-1,3-thiazol-2-yl]-2-(4-chlorophenoxy)acetamide301176-40-9C18H14Cl2N2O2S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(CCN1C(=O)C(=Cc2ccccc2)SC1=S)Nc1ccccc110 chemicals
O=C(C=Cc1ccccc1)Nc1ncc(Cc2ccccc2)s17 chemicals
O=C(CSc1nnc(Cc2ccccc2)o1)Nc1ccccc17 chemicals
O=C(CCCN1C(=O)C(=Cc2ccccc2)SC1=S)N1CCCCC15 chemicals
O=C(CSc1ncccn1)Nc1ncc(Cc2ccccc2)s14 chemicals
O=C(CCCN1C(=O)C(=Cc2ccccc2)SC1=S)N1CCOCC14 chemicals
O=C(CCCN1C(=O)C(=Cc2ccccc2)SC1=S)N1CCNCC14 chemicals![Scaffold O=C(CSc1nnc(Cc2ccccc2)[nH]1)NC1CCCCC1](/scaffold/CBTZTDMAEVXSAM-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(Cc2ccccc2)[nH]1)NC1CCCCC13 chemicals
O=C(COc1ccccc1)Nc1ncc(S(=O)(=O)c2ccccc2)s13 chemicals
O=C(CSc1nnc(Cc2ccccc2)o1)NC1CCCCC13 chemicals![Scaffold O=C(CSc1nnc(CN2CCOCC2)[nH]1)Nc1ccccc1](/scaffold/FYVSEUIOBWARFG-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(CN2CCOCC2)[nH]1)Nc1ccccc13 chemicals
O=C(CSc1ccccc1)Nc1nnc(Cc2ccccc2)s13 chemicals