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Murcko scaffold

N-(5-Benzyl-1,3-thiazol-2-yl)-2-pyrimidin-2-ylsulfanylacetamide scaffold

18 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
18
With full pages
4
Scaffold SMILES

O=C(CSc1ncccn1)Nc1ncc(Cc2ccccc2)s1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-(5-Benzyl-1,3-thiazol-2-yl)-2-pyrimidin-2-ylsulfanylacetamide page
Murcko scaffold O=C(CSc1ncccn1)Nc1ncc(Cc2ccccc2)s1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

N-(5-Benzyl-1,3-thiazol-2-yl)-2-pyrimidin-2-ylsulfanylacetamide chemical structure, C16H14N4OS2, CAS 842970-63-2
N-(5-Benzyl-1,3-thiazol-2-yl)-2-pyrimidin-2-ylsulfanylacetamide
CAS 842970-63-2C16H14N4OS2
2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(4-fluorobenzyl)-1,3-thiazol-2-yl]acetamide chemical structure, C18H17FN4OS2, CAS 618390-98-0
2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(4-fluorobenzyl)-1,3-thiazol-2-yl]acetamide
CAS 618390-98-0C18H17FN4OS2
N-[5-[(3-Chlorophenyl)methyl]-1,3-thiazol-2-yl]-2-pyrimidin-2-ylsulfanylacetamide chemical structure, C16H13ClN4OS2, CAS 708292-87-9
N-[5-[(3-Chlorophenyl)methyl]-1,3-thiazol-2-yl]-2-pyrimidin-2-ylsulfanylacetamide
CAS 708292-87-9C16H13ClN4OS2
N-[5-[(3,5-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-2-pyrimidin-2-ylsulfanylacetamide chemical structure, C16H12Cl2N4OS2, CAS 5291-99-6
N-[5-[(3,5-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-2-pyrimidin-2-ylsulfanylacetamide
CAS 5291-99-6C16H12Cl2N4OS2
N-(5-(4-Chlorobenzyl)thiazol-2-yl)-2-((4,6-dimethylpyrimidin-2-yl)thio)acetamide chemical structure, C18H17ClN4OS2, CAS 618390-84-4
N-(5-(4-Chlorobenzyl)thiazol-2-yl)-2-((4,6-dimethylpyrimidin-2-yl)thio)acetamide
CAS 618390-84-4C18H17ClN4OS2
N-(5-Benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide chemical structure, C18H18N4OS2, CAS 801227-82-7
N-(5-Benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide
CAS 801227-82-7C18H18N4OS2
N-[5-[(4-Fluorophenyl)methyl]-1,3-thiazol-2-yl]-2-pyrimidin-2-ylsulfanylacetamide chemical structure, C16H13FN4OS2, CAS 708996-13-8
N-[5-[(4-Fluorophenyl)methyl]-1,3-thiazol-2-yl]-2-pyrimidin-2-ylsulfanylacetamide
CAS 708996-13-8C16H13FN4OS2
2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-[5-[(3-methylphenyl)methyl]-1,3-thiazol-2-yl]acetamide chemical structure, C19H20N4OS2, CAS 708284-73-5
2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-[5-[(3-methylphenyl)methyl]-1,3-thiazol-2-yl]acetamide
CAS 708284-73-5C19H20N4OS2
N-[5-[(4-Bromophenyl)methyl]-1,3-thiazol-2-yl]-2-pyrimidin-2-ylsulfanylacetamide chemical structure, C16H13BrN4OS2, CAS 708287-38-1
N-[5-[(4-Bromophenyl)methyl]-1,3-thiazol-2-yl]-2-pyrimidin-2-ylsulfanylacetamide
CAS 708287-38-1C16H13BrN4OS2
2-Pyrimidin-2-ylsulfanyl-N-[5-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl]acetamide chemical structure, C17H13F3N4OS2, CAS 842970-88-1
2-Pyrimidin-2-ylsulfanyl-N-[5-[[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl]acetamide
CAS 842970-88-1C17H13F3N4OS2
N-[5-[(2,3-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide chemical structure, C18H16Cl2N4OS2, CAS 637322-39-5
N-[5-[(2,3-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide
CAS 637322-39-5C18H16Cl2N4OS2
N-[5-[(3,4-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide chemical structure, C18H16Cl2N4OS2, CAS 708998-94-1
N-[5-[(3,4-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide
CAS 708998-94-1C18H16Cl2N4OS2
N-[5-[(2,4-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-2-pyrimidin-2-ylsulfanylacetamide chemical structure, C16H12Cl2N4OS2, CAS 824945-59-7
N-[5-[(2,4-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-2-pyrimidin-2-ylsulfanylacetamide
CAS 824945-59-7C16H12Cl2N4OS2
N-[5-(2,6-Dichlorobenzyl)-1,3-thiazol-2-yl]-2-(pyrimidin-2-ylsulfanyl)acetamide chemical structure, C16H12Cl2N4OS2, CAS 842970-93-8
N-[5-(2,6-Dichlorobenzyl)-1,3-thiazol-2-yl]-2-(pyrimidin-2-ylsulfanyl)acetamide
CAS 842970-93-8C16H12Cl2N4OS2
N-[5-[[2-Chloro-5-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl]-2-pyrimidin-2-ylsulfanylacetamide chemical structure, C17H12ClF3N4OS2, CAS 708997-60-8
N-[5-[[2-Chloro-5-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl]-2-pyrimidin-2-ylsulfanylacetamide
CAS 708997-60-8C17H12ClF3N4OS2
N-(5-(4-Chloro-3-(trifluoromethyl)benzyl)thiazol-2-yl)-2-(pyrimidin-2-ylthio)acetamide chemical structure, C17H12ClF3N4OS2, CAS 842970-97-2
N-(5-(4-Chloro-3-(trifluoromethyl)benzyl)thiazol-2-yl)-2-(pyrimidin-2-ylthio)acetamide
CAS 842970-97-2C17H12ClF3N4OS2
N-[5-(3-Nitrobenzyl)-1,3-thiazol-2-yl]-2-(pyrimidin-2-ylsulfanyl)acetamide chemical structure, C16H13N5O3S2, CAS 847246-82-6
N-[5-(3-Nitrobenzyl)-1,3-thiazol-2-yl]-2-(pyrimidin-2-ylsulfanyl)acetamide
CAS 847246-82-6C16H13N5O3S2
SirReal1-O-propargyl chemical structure, C21H20N4O2S2, CAS 1862237-99-7
SirReal1-O-propargyl
CAS 1862237-99-7C21H20N4O2S2