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Murcko scaffold

Ring system with 3 rings and 23 atoms

33 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 23
Chemicals: 33
With full pages: 3

Scaffold SMILES

O=C(CSc1nnc(CN2CCOCC2)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CSc1nnc(CN2CCOCC2)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 33 of 33 chemicals

N-(2,6-Dimethylphenyl)-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C18H25N5O2S, CAS 5181-73-7

N-(2,6-Dimethylphenyl)-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide

CAS 5181-73-7C₁₈H₂₅N₅O₂S

Methyl 2-chloro-5-[({[4-methyl-5-(4-morpholinylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetyl)amino]benzoate chemical structure, C18H22ClN5O4S, CAS 701220-34-0

Methyl 2-chloro-5-[({[4-methyl-5-(4-morpholinylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetyl)amino]benzoate

CAS 701220-34-0C₁₈H₂₂ClN₅O₄S

2-[[4-Methyl-5-(4-morpholinylmethyl)-4H-1,2,4-triazol-3-yl]thio]-N-(3-methylphenyl)acetamide chemical structure, C17H23N5O2S, CAS 799265-64-8

2-[[4-Methyl-5-(4-morpholinylmethyl)-4H-1,2,4-triazol-3-yl]thio]-N-(3-methylphenyl)acetamide

CAS 799265-64-8C₁₇H₂₃N₅O₂S

N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C17H19ClF3N5O2S, CAS 702648-36-0

N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide

CAS 702648-36-0C₁₇H₁₉ClF₃N₅O₂S

N-(3-Chloro-4-methoxyphenyl)-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C17H22ClN5O3S, CAS 708289-19-4

N-(3-Chloro-4-methoxyphenyl)-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide

CAS 708289-19-4C₁₇H₂₂ClN₅O₃S

N-(2-Bromophenyl)-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C16H20BrN5O2S, CAS 708295-28-7

N-(2-Bromophenyl)-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide

CAS 708295-28-7C₁₆H₂₀BrN₅O₂S

N-(3-Bromophenyl)-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C16H20BrN5O2S, CAS 905540-70-7

N-(3-Bromophenyl)-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide

CAS 905540-70-7C₁₆H₂₀BrN₅O₂S

2-[[4-Methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C17H20F3N5O2S, CAS 876720-85-3

2-[[4-Methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide

CAS 876720-85-3C₁₇H₂₀F₃N₅O₂S

N-(3-Fluorophenyl)-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C16H20FN5O2S, CAS 876718-45-5

N-(3-Fluorophenyl)-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide

CAS 876718-45-5C₁₆H₂₀FN₅O₂S

N-(4-Acetylphenyl)-2-[[4-ethyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C19H25N5O3S, CAS 896656-48-7

N-(4-Acetylphenyl)-2-[[4-ethyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide

CAS 896656-48-7C₁₉H₂₅N₅O₃S

2-[[4-Ethyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C18H22F3N5O2S, CAS 896656-61-4

2-[[4-Ethyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide

CAS 896656-61-4C₁₈H₂₂F₃N₅O₂S

2-[[4-Ethyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-methoxyphenyl)acetamide chemical structure, C18H25N5O3S, CAS 896656-46-5

2-[[4-Ethyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-methoxyphenyl)acetamide

CAS 896656-46-5C₁₈H₂₅N₅O₃S

N-(5-Chloro-2-hydroxyphenyl)-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C16H20ClN5O3S, CAS 876718-51-3

N-(5-Chloro-2-hydroxyphenyl)-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide

CAS 876718-51-3C₁₆H₂₀ClN₅O₃S

N-(3-Chloro-4-methoxyphenyl)-2-[[4-ethyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C18H24ClN5O3S, CAS 878415-35-1

N-(3-Chloro-4-methoxyphenyl)-2-[[4-ethyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide

CAS 878415-35-1C₁₈H₂₄ClN₅O₃S

N-[4-(Difluoromethoxy)phenyl]-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C17H21F2N5O3S, CAS 901220-97-1

N-[4-(Difluoromethoxy)phenyl]-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide

CAS 901220-97-1C₁₇H₂₁F₂N₅O₃S

N-[2-(Difluoromethoxy)phenyl]-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C17H21F2N5O3S, CAS 886626-55-7

N-[2-(Difluoromethoxy)phenyl]-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide

CAS 886626-55-7C₁₇H₂₁F₂N₅O₃S

2-[[4-Methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2,4,6-trimethylphenyl)acetamide chemical structure, C19H27N5O2S, CAS 878680-18-3

2-[[4-Methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2,4,6-trimethylphenyl)acetamide

CAS 878680-18-3C₁₉H₂₇N₅O₂S

N-(3,5-Dichlorophenyl)-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C16H19Cl2N5O2S, CAS 878696-39-0

N-(3,5-Dichlorophenyl)-2-[[4-methyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide

CAS 878696-39-0C₁₆H₁₉Cl₂N₅O₂S

2-{[4-Ethyl-5-(morpholin-4-ylmethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2-hydroxyphenyl)acetamide chemical structure, C17H23N5O3S, CAS 929843-62-9

2-{[4-Ethyl-5-(morpholin-4-ylmethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2-hydroxyphenyl)acetamide

CAS 929843-62-9C₁₇H₂₃N₅O₃S

N-(4-Chloro-2-fluorophenyl)-2-{[4-methyl-5-(morpholin-4-ylmethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C16H19ClFN5O2S, CAS 905806-29-3

N-(4-Chloro-2-fluorophenyl)-2-{[4-methyl-5-(morpholin-4-ylmethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide

CAS 905806-29-3C₁₆H₁₉ClFN₅O₂S

2-{[4-Ethyl-5-(morpholin-4-ylmethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(5-fluoro-2-methylphenyl)acetamide chemical structure, C18H24FN5O2S, CAS 905798-07-4

2-{[4-Ethyl-5-(morpholin-4-ylmethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(5-fluoro-2-methylphenyl)acetamide

CAS 905798-07-4C₁₈H₂₄FN₅O₂S

N-(4-Ethoxyphenyl)-2-{[4-ethyl-5-(morpholin-4-ylmethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C19H27N5O3S, CAS 905807-23-0

N-(4-Ethoxyphenyl)-2-{[4-ethyl-5-(morpholin-4-ylmethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide

CAS 905807-23-0C₁₉H₂₇N₅O₃S

N-(4-Chlorophenyl)-2-{[4-ethyl-5-(morpholin-4-ylmethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C17H22ClN5O2S, CAS 924969-76-6

N-(4-Chlorophenyl)-2-{[4-ethyl-5-(morpholin-4-ylmethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide

CAS 924969-76-6C₁₇H₂₂ClN₅O₂S

N-(4-Chloro-2-methylphenyl)-2-{[4-ethyl-5-(morpholin-4-ylmethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C18H24ClN5O2S, CAS 915876-25-4

N-(4-Chloro-2-methylphenyl)-2-{[4-ethyl-5-(morpholin-4-ylmethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide

CAS 915876-25-4C₁₈H₂₄ClN₅O₂S