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Murcko scaffold

Ring system with 3 rings and 21 atoms

75 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
75
With full pages
5
Scaffold SMILES

O=C(Nc1ccccc1)N1CCN(c2ccccn2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)N1CCN(c2ccccn2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 75 chemicals

N-(4-tert-Butylphenyl)-4-(pyridin-2-yl)piperazine-1-carboxamide chemical structure, C20H26N4O, CAS 345972-68-1
N-(4-tert-Butylphenyl)-4-(pyridin-2-yl)piperazine-1-carboxamide
CAS 345972-68-1C20H26N4O
N-(4-Fluorophenyl)-4-(pyridin-2-yl)piperazine-1-carboxamide chemical structure, C16H17FN4O, CAS 435282-53-4
N-(4-Fluorophenyl)-4-(pyridin-2-yl)piperazine-1-carboxamide
CAS 435282-53-4C16H17FN4O
N-(4-Chlorophenyl)-4-(pyridin-2-yl)piperazine-1-carboxamide chemical structure, C16H17ClN4O, CAS 335282-62-7
N-(4-Chlorophenyl)-4-(pyridin-2-yl)piperazine-1-carboxamide
CAS 335282-62-7C16H17ClN4O
N-(2-Methoxyphenyl)-4-pyridin-2-ylpiperazine-1-carboxamide chemical structure, C17H20N4O2, CAS 335282-87-6
N-(2-Methoxyphenyl)-4-pyridin-2-ylpiperazine-1-carboxamide
CAS 335282-87-6C17H20N4O2
N-(3-Fluorophenyl)-4-(pyridin-2-yl)piperazine-1-carboxamide chemical structure, C16H17FN4O, CAS 335282-73-0
N-(3-Fluorophenyl)-4-(pyridin-2-yl)piperazine-1-carboxamide
CAS 335282-73-0C16H17FN4O
N-(4-Methoxyphenyl)-4-pyridin-2-ylpiperazine-1-carboxamide chemical structure, C17H20N4O2, CAS 380546-82-7
N-(4-Methoxyphenyl)-4-pyridin-2-ylpiperazine-1-carboxamide
CAS 380546-82-7C17H20N4O2
N-Methyl-N-phenyl-4-(2-pyridinyl)-1-piperazinecarboxamide chemical structure, C17H20N4O, CAS 694465-74-2
N-Methyl-N-phenyl-4-(2-pyridinyl)-1-piperazinecarboxamide
CAS 694465-74-2C17H20N4O
N-(3-Nitrophenyl)-4-pyridin-2-ylpiperazine-1-carboxamide chemical structure, C16H17N5O3, CAS 706769-37-1
N-(3-Nitrophenyl)-4-pyridin-2-ylpiperazine-1-carboxamide
CAS 706769-37-1C16H17N5O3
N-(2-Methoxy-5-methylphenyl)-4-pyridin-2-ylpiperazine-1-carboxamide chemical structure, C18H22N4O2, CAS 708223-32-9
N-(2-Methoxy-5-methylphenyl)-4-pyridin-2-ylpiperazine-1-carboxamide
CAS 708223-32-9C18H22N4O2
N-Methyl-N-(4-methylphenyl)-4-(pyridin-2-yl)piperazine-1-carboxamide chemical structure, C18H22N4O, CAS 700860-03-3
N-Methyl-N-(4-methylphenyl)-4-(pyridin-2-yl)piperazine-1-carboxamide
CAS 700860-03-3C18H22N4O
N-(3,4-Dimethoxyphenyl)-4-pyridin-2-ylpiperazine-1-carboxamide chemical structure, C18H22N4O3, CAS 701282-86-2
N-(3,4-Dimethoxyphenyl)-4-pyridin-2-ylpiperazine-1-carboxamide
CAS 701282-86-2C18H22N4O3
4-Pyridin-2-yl-N-[3-(trifluoromethyl)phenyl]piperazine-1-carboxamide chemical structure, C17H17F3N4O, CAS 335282-67-2
4-Pyridin-2-yl-N-[3-(trifluoromethyl)phenyl]piperazine-1-carboxamide
CAS 335282-67-2C17H17F3N4O
N-(2,3-Dichlorophenyl)-4-pyridin-2-ylpiperazine-1-carboxamide chemical structure, C16H16Cl2N4O, CAS 335282-81-0
N-(2,3-Dichlorophenyl)-4-pyridin-2-ylpiperazine-1-carboxamide
CAS 335282-81-0C16H16Cl2N4O
N-{4-[(Dimethylamino)sulfonyl]phenyl}-4-(2-pyridinyl)tetrahydro-1(2H)-pyrazinecarboxamide chemical structure, C18H23N5O3S, CAS 692733-02-1
N-{4-[(Dimethylamino)sulfonyl]phenyl}-4-(2-pyridinyl)tetrahydro-1(2H)-pyrazinecarboxamide
CAS 692733-02-1C18H23N5O3S
4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[4-(dimethylsulfamoyl)phenyl]piperazine-1-carboxamide chemical structure, C19H21ClF3N5O3S, CAS 692733-09-8
4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[4-(dimethylsulfamoyl)phenyl]piperazine-1-carboxamide
CAS 692733-09-8C19H21ClF3N5O3S
4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[2-(2-nitroethyl)phenyl]piperazine-1-carboxamide chemical structure, C19H19ClF3N5O3, CAS 339110-84-8
4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[2-(2-nitroethyl)phenyl]piperazine-1-carboxamide
CAS 339110-84-8C19H19ClF3N5O3
N-(5-Chloro-2-methoxyphenyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide chemical structure, C18H18ClF3N4O2, CAS 260553-24-0
N-(5-Chloro-2-methoxyphenyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide
CAS 260553-24-0C18H18ClF3N4O2
Ethyl 5-cyano-6-[4-(phenylcarbamoyl)piperazin-1-yl]-2-(trifluoromethyl)pyridine-3-carboxylate chemical structure, C21H20F3N5O3, CAS 4786-97-4
Ethyl 5-cyano-6-[4-(phenylcarbamoyl)piperazin-1-yl]-2-(trifluoromethyl)pyridine-3-carboxylate
CAS 4786-97-4C21H20F3N5O3
N-(4-Chloro-3-nitrophenyl)-4-[3-(trifluoromethyl)pyridin-2-yl]tetrahydropyrazine-1(2H)-carboxamide chemical structure, C17H15ClF3N5O3, CAS 260798-64-9
N-(4-Chloro-3-nitrophenyl)-4-[3-(trifluoromethyl)pyridin-2-yl]tetrahydropyrazine-1(2H)-carboxamide
CAS 260798-64-9C17H15ClF3N5O3
N-(4-Nitrophenyl)-4-pyridin-2-ylpiperazine-1-carboxamide chemical structure, C16H17N5O3, CAS 690650-48-7
N-(4-Nitrophenyl)-4-pyridin-2-ylpiperazine-1-carboxamide
CAS 690650-48-7C16H17N5O3
N-(4-Methylphenyl)-4-(pyridin-2-yl)piperazine-1-carboxamide chemical structure, C17H20N4O, CAS 335282-70-7
N-(4-Methylphenyl)-4-(pyridin-2-yl)piperazine-1-carboxamide
CAS 335282-70-7C17H20N4O
Methyl 3-[(4-pyridin-2-ylpiperazine-1-carbonyl)amino]benzoate chemical structure, C18H20N4O3, CAS 1022049-29-1
Methyl 3-[(4-pyridin-2-ylpiperazine-1-carbonyl)amino]benzoate
CAS 1022049-29-1C18H20N4O3
4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[3-(trifluoromethyl)phenyl]piperazine-1-carboxamide chemical structure, C18H15ClF6N4O, CAS 856189-81-6
4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[3-(trifluoromethyl)phenyl]piperazine-1-carboxamide
CAS 856189-81-6C18H15ClF6N4O
N-(4-Chlorophenyl)-4-(6-chloro-2-pyridinyl)tetrahydro-1(2H)-pyrazinecarboxamide chemical structure, C16H16Cl2N4O, CAS 339107-26-5
N-(4-Chlorophenyl)-4-(6-chloro-2-pyridinyl)tetrahydro-1(2H)-pyrazinecarboxamide
CAS 339107-26-5C16H16Cl2N4O