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Murcko scaffold

Ring system with 3 rings and 24 atoms

21 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
21
With full pages
6
Scaffold SMILES

O=C(Nc1ccc(S(=O)(=O)N2CCCCC2)cc1)c1ccncn1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccc(S(=O)(=O)N2CCCCC2)cc1)c1ccncn1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

5-Chloro-2-methylsulfanyl-N-(4-piperidin-1-ylsulfonylphenyl)pyrimidine-4-carboxamide chemical structure, C17H19ClN4O3S2, CAS 838849-33-5
5-Chloro-2-methylsulfanyl-N-(4-piperidin-1-ylsulfonylphenyl)pyrimidine-4-carboxamide
CAS 838849-33-5C17H19ClN4O3S2
5-Chloro-N-{4-[(4-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(methylsulfanyl)pyrimidine-4-carboxamide chemical structure, C18H21ClN4O3S2, CAS 879944-86-2
5-Chloro-N-{4-[(4-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(methylsulfanyl)pyrimidine-4-carboxamide
CAS 879944-86-2C18H21ClN4O3S2
5-Chloro-N-{4-[(3-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(methylsulfanyl)pyrimidine-4-carboxamide chemical structure, C18H21ClN4O3S2, CAS 879945-30-9
5-Chloro-N-{4-[(3-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(methylsulfanyl)pyrimidine-4-carboxamide
CAS 879945-30-9C18H21ClN4O3S2
5-Chloro-N-{4-[(2-ethylpiperidin-1-yl)sulfonyl]phenyl}-2-(methylsulfanyl)pyrimidine-4-carboxamide chemical structure, C19H23ClN4O3S2, CAS 879953-37-4
5-Chloro-N-{4-[(2-ethylpiperidin-1-yl)sulfonyl]phenyl}-2-(methylsulfanyl)pyrimidine-4-carboxamide
CAS 879953-37-4C19H23ClN4O3S2
5-Chloro-2-(ethylsulfanyl)-N-[4-(piperidin-1-ylsulfonyl)phenyl]pyrimidine-4-carboxamide chemical structure, C18H21ClN4O3S2, CAS 879931-24-5
5-Chloro-2-(ethylsulfanyl)-N-[4-(piperidin-1-ylsulfonyl)phenyl]pyrimidine-4-carboxamide
CAS 879931-24-5C18H21ClN4O3S2
5-Chloro-2-(ethylsulfanyl)-N-{4-[(4-methylpiperidin-1-yl)sulfonyl]phenyl}pyrimidine-4-carboxamide chemical structure, C19H23ClN4O3S2, CAS 879953-51-2
5-Chloro-2-(ethylsulfanyl)-N-{4-[(4-methylpiperidin-1-yl)sulfonyl]phenyl}pyrimidine-4-carboxamide
CAS 879953-51-2C19H23ClN4O3S2
5-Chloro-N-{4-[(2-ethylpiperidin-1-yl)sulfonyl]phenyl}-2-(ethylsulfanyl)pyrimidine-4-carboxamide chemical structure, C20H25ClN4O3S2, CAS 879953-65-8
5-Chloro-N-{4-[(2-ethylpiperidin-1-yl)sulfonyl]phenyl}-2-(ethylsulfanyl)pyrimidine-4-carboxamide
CAS 879953-65-8C20H25ClN4O3S2
5-Chloro-N-{4-[(4-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(propylsulfanyl)pyrimidine-4-carboxamide chemical structure, C20H25ClN4O3S2, CAS 879926-68-8
5-Chloro-N-{4-[(4-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(propylsulfanyl)pyrimidine-4-carboxamide
CAS 879926-68-8C20H25ClN4O3S2
5-Chloro-N-{4-[(2-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(propylsulfanyl)pyrimidine-4-carboxamide chemical structure, C20H25ClN4O3S2, CAS 879926-78-0
5-Chloro-N-{4-[(2-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(propylsulfanyl)pyrimidine-4-carboxamide
CAS 879926-78-0C20H25ClN4O3S2
5-Chloro-N-{4-[(3-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(propylsulfanyl)pyrimidine-4-carboxamide chemical structure, C20H25ClN4O3S2, CAS 879926-73-5
5-Chloro-N-{4-[(3-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(propylsulfanyl)pyrimidine-4-carboxamide
CAS 879926-73-5C20H25ClN4O3S2
5-Chloro-N-[4-(piperidin-1-ylsulfonyl)phenyl]-2-(propan-2-ylsulfanyl)pyrimidine-4-carboxamide chemical structure, C19H23ClN4O3S2, CAS 874399-39-0
5-Chloro-N-[4-(piperidin-1-ylsulfonyl)phenyl]-2-(propan-2-ylsulfanyl)pyrimidine-4-carboxamide
CAS 874399-39-0C19H23ClN4O3S2
5-Chloro-N-{4-[(2-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(propan-2-ylsulfanyl)pyrimidine-4-carboxamide chemical structure, C20H25ClN4O3S2, CAS 874399-32-3
5-Chloro-N-{4-[(2-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(propan-2-ylsulfanyl)pyrimidine-4-carboxamide
CAS 874399-32-3C20H25ClN4O3S2
5-Chloro-N-{4-[(3-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(propan-2-ylsulfanyl)pyrimidine-4-carboxamide chemical structure, C20H25ClN4O3S2, CAS 874399-41-4
5-Chloro-N-{4-[(3-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(propan-2-ylsulfanyl)pyrimidine-4-carboxamide
CAS 874399-41-4C20H25ClN4O3S2
5-Chloro-N-{4-[(3-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(methylsulfonyl)pyrimidine-4-carboxamide chemical structure, C18H21ClN4O5S2, CAS 879938-54-2
5-Chloro-N-{4-[(3-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(methylsulfonyl)pyrimidine-4-carboxamide
CAS 879938-54-2C18H21ClN4O5S2
5-Chloro-N-{4-[(2-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(methylsulfanyl)pyrimidine-4-carboxamide chemical structure, C18H21ClN4O3S2, CAS 879945-02-5
5-Chloro-N-{4-[(2-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(methylsulfanyl)pyrimidine-4-carboxamide
CAS 879945-02-5C18H21ClN4O3S2
5-Chloro-N-[4-(piperidin-1-ylsulfonyl)phenyl]-2-(propylsulfanyl)pyrimidine-4-carboxamide chemical structure, C19H23ClN4O3S2, CAS 879953-16-9
5-Chloro-N-[4-(piperidin-1-ylsulfonyl)phenyl]-2-(propylsulfanyl)pyrimidine-4-carboxamide
CAS 879953-16-9C19H23ClN4O3S2
5-Chloro-2-(ethylsulfanyl)-N-{4-[(2-methylpiperidin-1-yl)sulfonyl]phenyl}pyrimidine-4-carboxamide chemical structure, C19H23ClN4O3S2, CAS 879931-54-1
5-Chloro-2-(ethylsulfanyl)-N-{4-[(2-methylpiperidin-1-yl)sulfonyl]phenyl}pyrimidine-4-carboxamide
CAS 879931-54-1C19H23ClN4O3S2
5-Chloro-N-[4-(piperidin-1-ylsulfonyl)phenyl]-2-(prop-2-en-1-ylsulfanyl)pyrimidine-4-carboxamide chemical structure, C19H21ClN4O3S2, CAS 874129-79-0
5-Chloro-N-[4-(piperidin-1-ylsulfonyl)phenyl]-2-(prop-2-en-1-ylsulfanyl)pyrimidine-4-carboxamide
CAS 874129-79-0C19H21ClN4O3S2
5-Chloro-N-{4-[(2-ethylpiperidin-1-yl)sulfonyl]phenyl}-2-(propan-2-ylsulfanyl)pyrimidine-4-carboxamide chemical structure, C21H27ClN4O3S2, CAS 874146-11-9
5-Chloro-N-{4-[(2-ethylpiperidin-1-yl)sulfonyl]phenyl}-2-(propan-2-ylsulfanyl)pyrimidine-4-carboxamide
CAS 874146-11-9C21H27ClN4O3S2
5-Chloro-N-{4-[(4-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(prop-2-en-1-ylsulfanyl)pyrimidine-4-carboxamide chemical structure, C20H23ClN4O3S2, CAS 874147-06-5
5-Chloro-N-{4-[(4-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(prop-2-en-1-ylsulfanyl)pyrimidine-4-carboxamide
CAS 874147-06-5C20H23ClN4O3S2
5-Chloro-N-{4-[(2-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(prop-2-en-1-ylsulfanyl)pyrimidine-4-carboxamide chemical structure, C20H23ClN4O3S2, CAS 874206-30-1
5-Chloro-N-{4-[(2-methylpiperidin-1-yl)sulfonyl]phenyl}-2-(prop-2-en-1-ylsulfanyl)pyrimidine-4-carboxamide
CAS 874206-30-1C20H23ClN4O3S2