Murcko scaffold
Ring system with 3 rings and 20 atoms
1,651 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 20
- Chemicals
- 1,651
- With full pages
- 183
Scaffold SMILES
O=C1NC(c2ccccc2)C(=Cc2ccccc2)C1=O
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 1,651 chemicals
![5-(3-Fluorophenyl)-4-[hydroxy-(4-methylphenyl)methylidene]-1-(2-hydroxypropyl)pyrrolidine-2,3-dione chemical structure, C21H20FNO4, CAS 440108-82-7](/s/JDDZXMLLWWAGRX-UHFFFAOYSA-N.svg)
5-(3-Fluorophenyl)-4-[hydroxy-(4-methylphenyl)methylidene]-1-(2-hydroxypropyl)pyrrolidine-2,3-dione
CAS 440108-82-7C21H20FNO4
![5-(3,4-Dimethoxyphenyl)-1-[2-(dimethylamino)ethyl]-4-(2,5-dimethylbenzoyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H30N2O5](/s/QKJPTSAXUVTTQK-UHFFFAOYSA-N.svg)
5-(3,4-Dimethoxyphenyl)-1-[2-(dimethylamino)ethyl]-4-(2,5-dimethylbenzoyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C25H30N2O5
![1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-(4-methoxy-2-methylbenzoyl)-5-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H32N2O7](/s/DPTPPOREDBLYLP-UHFFFAOYSA-N.svg)
1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-(4-methoxy-2-methylbenzoyl)-5-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one
C26H32N2O7
![1-[2-(Dimethylamino)ethyl]-4-(2,5-dimethylbenzoyl)-5-(3-ethoxy-4-hydroxyphenyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H30N2O5](/s/WCMOAEFPIGOVDQ-UHFFFAOYSA-N.svg)
1-[2-(Dimethylamino)ethyl]-4-(2,5-dimethylbenzoyl)-5-(3-ethoxy-4-hydroxyphenyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C25H30N2O5
![1-[2-(Dimethylamino)ethyl]-4-(2,5-dimethylbenzoyl)-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H28N2O5](/s/QSFSIWPRKGTDNK-UHFFFAOYSA-N.svg)
1-[2-(Dimethylamino)ethyl]-4-(2,5-dimethylbenzoyl)-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one
C24H28N2O5
![4-[(3-Chloro-4-methoxyphenyl)-hydroxymethylidene]-5-(2,5-dimethoxyphenyl)-1-[2-(dimethylamino)ethyl]pyrrolidine-2,3-dione chemical structure, C24H27ClN2O6](/s/NTALZCKHIVHKBK-UHFFFAOYSA-N.svg)
4-[(3-Chloro-4-methoxyphenyl)-hydroxymethylidene]-5-(2,5-dimethoxyphenyl)-1-[2-(dimethylamino)ethyl]pyrrolidine-2,3-dione
C24H27ClN2O6
![4-Benzoyl-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(3-methoxy-4-propoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H32N2O5](/s/HXQGQUPAJCJDOD-UHFFFAOYSA-N.svg)
4-Benzoyl-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(3-methoxy-4-propoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one
C26H32N2O5
![1-[2-(Dimethylamino)ethyl]-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-4-[4-(2-methylpropoxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H32N2O6](/s/YHOHOXJNAZMSLI-UHFFFAOYSA-N.svg)
1-[2-(Dimethylamino)ethyl]-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-4-[4-(2-methylpropoxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C26H32N2O6
![1-[2-(Dimethylamino)ethyl]-5-(4-hydroxy-3-methoxyphenyl)-4-[hydroxy-(4-propoxyphenyl)methylidene]pyrrolidine-2,3-dione chemical structure, C25H30N2O6](/s/OJSKKJJLXLGSCB-UHFFFAOYSA-N.svg)
1-[2-(Dimethylamino)ethyl]-5-(4-hydroxy-3-methoxyphenyl)-4-[hydroxy-(4-propoxyphenyl)methylidene]pyrrolidine-2,3-dione
C25H30N2O6
![N,N-Diethyl-4-[4-hydroxy-1-(2-methoxyethyl)-5-oxo-2-phenyl-2,5-dihydro-1H-pyrrole-3-carbonyl]benzene-1-sulfonamide chemical structure, C24H28N2O6S](/s/XHQZUTNHSWRWTD-UHFFFAOYSA-N.svg)
N,N-Diethyl-4-[4-hydroxy-1-(2-methoxyethyl)-5-oxo-2-phenyl-2,5-dihydro-1H-pyrrole-3-carbonyl]benzene-1-sulfonamide
C24H28N2O6S
![4-[(4-Bromophenyl)-hydroxymethylidene]-1-(2-hydroxyethyl)-5-(4-methylphenyl)pyrrolidine-2,3-dione chemical structure, C20H18BrNO4, CAS 333776-73-1](/s/CHVSFRGQBDRRDQ-UHFFFAOYSA-N.svg)
4-[(4-Bromophenyl)-hydroxymethylidene]-1-(2-hydroxyethyl)-5-(4-methylphenyl)pyrrolidine-2,3-dione
CAS 333776-73-1C20H18BrNO4
1-Butyl-3-hydroxy-4-(4-methoxybenzoyl)-5-(3-nitrophenyl)-1H-pyrrol-2(5H)-one
CAS 332170-19-1C22H22N2O6
![4-[Hydroxy(phenyl)methylidene]-1-(3-methoxypropyl)-5-phenylpyrrolidine-2,3-dione chemical structure, C21H21NO4](/s/IUCSIOARAYNGLO-UHFFFAOYSA-N.svg)
4-[Hydroxy(phenyl)methylidene]-1-(3-methoxypropyl)-5-phenylpyrrolidine-2,3-dione
C21H21NO4
![5-(4-Chlorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxypropyl)pyrrolidine-2,3-dione chemical structure, C21H20ClNO4](/s/HJCORSXGJIEIBC-UHFFFAOYSA-N.svg)
5-(4-Chlorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxypropyl)pyrrolidine-2,3-dione
C21H20ClNO4
![5-(4-Fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxypropyl)pyrrolidine-2,3-dione chemical structure, C21H20FNO4](/s/FIPIXTATXJICBD-UHFFFAOYSA-N.svg)
5-(4-Fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxypropyl)pyrrolidine-2,3-dione
C21H20FNO4
![5-(4-Hydroxy-3-methoxyphenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxypropyl)pyrrolidine-2,3-dione chemical structure, C22H23NO6](/s/FGZOTZRPRXNEHA-UHFFFAOYSA-N.svg)
5-(4-Hydroxy-3-methoxyphenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxypropyl)pyrrolidine-2,3-dione
C22H23NO6
![3-[3-[Hydroxy-(4-methylphenyl)methylidene]-2-(4-methylphenyl)-4,5-dioxopyrrolidin-1-yl]propanoic acid chemical structure, C22H21NO5](/s/RQJMVHWEHCMZQS-UHFFFAOYSA-N.svg)
3-[3-[Hydroxy-(4-methylphenyl)methylidene]-2-(4-methylphenyl)-4,5-dioxopyrrolidin-1-yl]propanoic acid
C22H21NO5
![1-[3-(Dimethylamino)propyl]-4-[(4-fluorophenyl)-hydroxymethylidene]-5-(4-methylphenyl)pyrrolidine-2,3-dione chemical structure, C23H25FN2O3](/s/RHJNWNYWTJAAOJ-UHFFFAOYSA-N.svg)
1-[3-(Dimethylamino)propyl]-4-[(4-fluorophenyl)-hydroxymethylidene]-5-(4-methylphenyl)pyrrolidine-2,3-dione
C23H25FN2O3
![5-(4-Chlorophenyl)-1-[3-(dimethylamino)propyl]-3-hydroxy-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H25ClN2O3](/s/YDCWPCVSJXEITH-UHFFFAOYSA-N.svg)
5-(4-Chlorophenyl)-1-[3-(dimethylamino)propyl]-3-hydroxy-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-one
C23H25ClN2O3
![1-[3-(Dimethylamino)propyl]-4-[hydroxy-(4-methylphenyl)methylidene]-5-(4-methylphenyl)pyrrolidine-2,3-dione chemical structure, C24H28N2O3](/s/RMINPJJNSOXGHQ-UHFFFAOYSA-N.svg)
1-[3-(Dimethylamino)propyl]-4-[hydroxy-(4-methylphenyl)methylidene]-5-(4-methylphenyl)pyrrolidine-2,3-dione
C24H28N2O3
![1-[3-(Dimethylamino)propyl]-5-(2-fluorophenyl)-4-[(4-fluorophenyl)-hydroxymethylidene]pyrrolidine-2,3-dione chemical structure, C22H22F2N2O3](/s/FRNFTWIFOHVCJQ-UHFFFAOYSA-N.svg)
1-[3-(Dimethylamino)propyl]-5-(2-fluorophenyl)-4-[(4-fluorophenyl)-hydroxymethylidene]pyrrolidine-2,3-dione
C22H22F2N2O3
![5-(3,4-Dimethoxyphenyl)-1-[3-(dimethylamino)propyl]-4-[(4-fluorophenyl)-hydroxymethylidene]pyrrolidine-2,3-dione chemical structure, C24H27FN2O5](/s/ZJTSYPKZIITEDS-UHFFFAOYSA-N.svg)
5-(3,4-Dimethoxyphenyl)-1-[3-(dimethylamino)propyl]-4-[(4-fluorophenyl)-hydroxymethylidene]pyrrolidine-2,3-dione
C24H27FN2O5
![1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-(4-methoxybenzoyl)-5-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H26N2O5](/s/VFKGOFCPHLSBRH-UHFFFAOYSA-N.svg)
1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-(4-methoxybenzoyl)-5-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one
C23H26N2O5
![1-[3-(Dimethylamino)propyl]-3-hydroxy-4-(4-methoxybenzoyl)-5-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H28N2O5](/s/PPSFJQYNKZKHNU-UHFFFAOYSA-N.svg)
1-[3-(Dimethylamino)propyl]-3-hydroxy-4-(4-methoxybenzoyl)-5-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one
C24H28N2O5
- 4-{1-[2-(Dimethylamino)ethyl]-4-hydroxy-5-oxo-2-phenyl-2,5-dihydro-1H-pyrrole-3-carbonyl}-N,N-dimethylbenzene-1-sulfonamideC23H27N3O5S
- 5-(2-Fluorophenyl)-3-hydroxy-1-(3-methoxypropyl)-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-oneC22H22FNO4
- 1-[2-(Dimethylamino)ethyl]-4-[(4-fluorophenyl)-hydroxymethylidene]-5-(4-methoxyphenyl)pyrrolidine-2,3-dioneC22H23FN2O4
- 1-[2-(Dimethylamino)ethyl]-4-[(4-fluorophenyl)-hydroxymethylidene]-5-(4-methylphenyl)pyrrolidine-2,3-dioneC22H23FN2O3
- 1-[2-(Dimethylamino)ethyl]-4-(4-ethoxy-3-methylbenzoyl)-3-hydroxy-5-phenyl-2,5-dihydro-1H-pyrrol-2-oneC24H28N2O4
- 1-[3-(Dimethylamino)propyl]-4-(4-ethoxy-3-methylbenzoyl)-3-hydroxy-5-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-oneC26H32N2O5
- 1-[3-(Dimethylamino)propyl]-5-(4-fluorophenyl)-4-[hydroxy-(3-methyl-4-propoxyphenyl)methylidene]pyrrolidine-2,3-dioneC26H31FN2O4
- 1-[3-(Dimethylamino)propyl]-5-(2-fluorophenyl)-4-[hydroxy-(3-methyl-4-propoxyphenyl)methylidene]pyrrolidine-2,3-dioneC26H31FN2O4
- 1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-[3-methyl-4-(prop-2-en-1-yloxy)benzoyl]-5-phenyl-2,5-dihydro-1H-pyrrol-2-oneC25H28N2O4
- 1-[2-(Dimethylamino)ethyl]-5-(4-fluorophenyl)-4-[hydroxy-(3-methyl-4-prop-2-enoxyphenyl)methylidene]pyrrolidine-2,3-dioneC25H27FN2O4
- 1-[3-(Dimethylamino)propyl]-4-[hydroxy-(3-methyl-4-prop-2-enoxyphenyl)methylidene]-5-(4-methylphenyl)pyrrolidine-2,3-dioneC27H32N2O4
- 1-[3-(Dimethylamino)propyl]-5-(4-fluorophenyl)-4-[hydroxy-(3-methyl-4-prop-2-enoxyphenyl)methylidene]pyrrolidine-2,3-dioneC26H29FN2O4
- 1-[3-(Dimethylamino)propyl]-5-(2-fluorophenyl)-4-[hydroxy-(3-methyl-4-prop-2-enoxyphenyl)methylidene]pyrrolidine-2,3-dioneC26H29FN2O4
- 1-[2-(Dimethylamino)ethyl]-4-[(4-ethoxy-2-methylphenyl)-hydroxymethylidene]-5-(4-methoxyphenyl)pyrrolidine-2,3-dioneC25H30N2O5
- 1-[2-(Dimethylamino)ethyl]-4-[(4-ethoxy-2-methylphenyl)-hydroxymethylidene]-5-(4-fluorophenyl)pyrrolidine-2,3-dioneC24H27FN2O4
- 5-(3,4-Dimethoxyphenyl)-1-[2-(dimethylamino)ethyl]-4-[(4-ethoxy-2-methylphenyl)-hydroxymethylidene]pyrrolidine-2,3-dioneC26H32N2O6
- 1-[3-(Dimethylamino)propyl]-4-[(4-ethoxy-2-methylphenyl)-hydroxymethylidene]-5-(4-methylphenyl)pyrrolidine-2,3-dioneC26H32N2O4
- 1-[3-(Dimethylamino)propyl]-4-[(4-ethoxy-2-methylphenyl)-hydroxymethylidene]-5-(4-fluorophenyl)pyrrolidine-2,3-dioneC25H29FN2O4
- 1-[3-(Dimethylamino)propyl]-3-hydroxy-4-(2-methyl-4-propoxybenzoyl)-5-phenyl-2,5-dihydro-1H-pyrrol-2-oneC26H32N2O4
- 1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-[2-methyl-4-(prop-2-en-1-yloxy)benzoyl]-5-phenyl-2,5-dihydro-1H-pyrrol-2-oneC25H28N2O4
- 1-[2-(Dimethylamino)ethyl]-4-[hydroxy-(2-methyl-4-prop-2-enoxyphenyl)methylidene]-5-(4-methoxyphenyl)pyrrolidine-2,3-dioneC26H30N2O5
- 1-[2-(Dimethylamino)ethyl]-5-(2-fluorophenyl)-4-[hydroxy-(2-methyl-4-prop-2-enoxyphenyl)methylidene]pyrrolidine-2,3-dioneC25H27FN2O4
- 1-[3-(Dimethylamino)propyl]-5-(4-fluorophenyl)-4-[hydroxy-(2-methyl-4-prop-2-enoxyphenyl)methylidene]pyrrolidine-2,3-dioneC26H29FN2O4
- 4-Benzoyl-3-hydroxy-1-(2-methoxyethyl)-5-[4-(prop-2-en-1-yloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-oneC23H23NO5
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold c1ccc(Oc2c[nH]nc2-c2ccccc2)cc1](/scaffold/VIKMERLRUOOJRO-UHFFFAOYSA-N/structure.svg)
c1ccc(Oc2c[nH]nc2-c2ccccc2)cc147 chemicals![Scaffold O=c1cc(Cc2nncn2-c2ccccc2)[nH]c(=O)[nH]1](/scaffold/NUYPVNXNLJEHMU-UHFFFAOYSA-N/structure.svg)
O=c1cc(Cc2nncn2-c2ccccc2)[nH]c(=O)[nH]126 chemicals
O=S(=O)(c1ccccc1)N1CCN=C1c1ccccc119 chemicals![Scaffold S=c1[nH]nc(-c2ccccc2)n1Cc1ccccc1](/scaffold/NXUULZDTTMJDAI-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(-c2ccccc2)n1Cc1ccccc116 chemicals
O=C1NC(c2cccnc2)C(=Cc2ccccc2)C1=O15 chemicals
O=C(c1ccccc1)C1CNCC1c1ccccc113 chemicals![Scaffold O=C(c1ccccc1)c1cn[nH]c1-c1ccccc1](/scaffold/DPVDUFOFGIXNIE-UHFFFAOYSA-N/structure.svg)
O=C(c1ccccc1)c1cn[nH]c1-c1ccccc111 chemicals
O=C(c1conc1-c1ccccc1)N1CCCCC111 chemicals
O=C1NC(c2ccncc2)C(=Cc2ccccc2)C1=O10 chemicals
c1ccc(-n2ccnc2Nc2ncccn2)cc18 chemicals
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O=C1C=C(c2ccccc2)C(Cc2ccccc2)O17 chemicals