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Murcko scaffold

Ring system with 3 rings and 20 atoms

107 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 20
Chemicals: 107
With full pages: 10

Scaffold SMILES

O=C1NC(c2ccncc2)C(=Cc2ccccc2)C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1NC(c2ccncc2)C(=Cc2ccccc2)C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 107 chemicals

3-Hydroxy-4-(3-methoxybenzoyl)-1-(2-methoxyethyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C20H20N2O5

3-Hydroxy-4-(3-methoxybenzoyl)-1-(2-methoxyethyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₀H₂₀N₂O₅

4-(3-Ethoxybenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C21H22N2O5

4-(3-Ethoxybenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₁H₂₂N₂O₅

1-[2-(Diethylamino)ethyl]-4-(4-fluorobenzoyl)-3-hydroxy-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H24FN3O3

1-[2-(Diethylamino)ethyl]-4-(4-fluorobenzoyl)-3-hydroxy-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₂H₂₄FN₃O₃

1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-(4-propoxybenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27N3O4

1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-(4-propoxybenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₃H₂₇N₃O₄

3-Hydroxy-1-(3-methoxypropyl)-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H24N2O5

3-Hydroxy-1-(3-methoxypropyl)-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₃H₂₄N₂O₅

1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-[4-(2-methylpropoxy)benzoyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H29N3O4

1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-[4-(2-methylpropoxy)benzoyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₄H₂₉N₃O₄

1-[3-(Dimethylamino)propyl]-3-hydroxy-4-(4-methylbenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H25N3O3

1-[3-(Dimethylamino)propyl]-3-hydroxy-4-(4-methylbenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₂H₂₅N₃O₃

1-[3-(Dimethylamino)propyl]-3-hydroxy-4-(4-methoxy-2-methylbenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27N3O4

1-[3-(Dimethylamino)propyl]-3-hydroxy-4-(4-methoxy-2-methylbenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₃H₂₇N₃O₄

3-Hydroxy-4-(4-methoxy-2-methylbenzoyl)-1-(2-methoxyethyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C21H22N2O5

3-Hydroxy-4-(4-methoxy-2-methylbenzoyl)-1-(2-methoxyethyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₁H₂₂N₂O₅

3-Hydroxy-1-(2-methoxyethyl)-4-[2-methyl-4-(2-methylpropoxy)benzoyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H28N2O5

3-Hydroxy-1-(2-methoxyethyl)-4-[2-methyl-4-(2-methylpropoxy)benzoyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₄H₂₈N₂O₅

1-[3-(Dimethylamino)propyl]-3-hydroxy-4-[2-methyl-4-(propan-2-yloxy)benzoyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H31N3O4, CAS 505079-86-7

1-[3-(Dimethylamino)propyl]-3-hydroxy-4-[2-methyl-4-(propan-2-yloxy)benzoyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 505079-86-7C₂₅H₃₁N₃O₄

4-(4-Butoxy-3-methylbenzoyl)-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H31N3O4

4-(4-Butoxy-3-methylbenzoyl)-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₅H₃₁N₃O₄

3-Hydroxy-1-(2-methoxyethyl)-4-[3-methyl-4-(2-methylpropoxy)benzoyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H28N2O5

3-Hydroxy-1-(2-methoxyethyl)-4-[3-methyl-4-(2-methylpropoxy)benzoyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₄H₂₈N₂O₅

1-[3-(Dimethylamino)propyl]-3-hydroxy-4-[3-methyl-4-(propan-2-yloxy)benzoyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H31N3O4, CAS 510712-13-7

1-[3-(Dimethylamino)propyl]-3-hydroxy-4-[3-methyl-4-(propan-2-yloxy)benzoyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 510712-13-7C₂₅H₃₁N₃O₄

1-[3-(Diethylamino)propyl]-3-hydroxy-4-(4-methylbenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H29N3O3, CAS 608108-34-5

1-[3-(Diethylamino)propyl]-3-hydroxy-4-(4-methylbenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 608108-34-5C₂₄H₂₉N₃O₃

1-[3-(Dimethylamino)propyl]-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H25N3O4

1-[3-(Dimethylamino)propyl]-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₂H₂₅N₃O₄

3-Hydroxy-1-(2-methoxyethyl)-4-(3-propoxybenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H24N2O5, CAS 608500-69-2

3-Hydroxy-1-(2-methoxyethyl)-4-(3-propoxybenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 608500-69-2C₂₂H₂₄N₂O₅

3-Hydroxy-4-(3-methoxybenzoyl)-1-(3-methoxypropyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C21H22N2O5, CAS 608501-55-9

3-Hydroxy-4-(3-methoxybenzoyl)-1-(3-methoxypropyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 608501-55-9C₂₁H₂₂N₂O₅

4-(3-Ethoxybenzoyl)-3-hydroxy-1-(3-methoxypropyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H24N2O5

4-(3-Ethoxybenzoyl)-3-hydroxy-1-(3-methoxypropyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₂H₂₄N₂O₅

1-[2-(Dimethylamino)ethyl]-4-(3-ethoxybenzoyl)-3-hydroxy-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H25N3O4

1-[2-(Dimethylamino)ethyl]-4-(3-ethoxybenzoyl)-3-hydroxy-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₂H₂₅N₃O₄

1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-(3-propoxybenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27N3O4, CAS 608504-16-1

1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-(3-propoxybenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 608504-16-1C₂₃H₂₇N₃O₄

1-[2-(Diethylamino)ethyl]-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27N3O4, CAS 608508-50-5

1-[2-(Diethylamino)ethyl]-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 608508-50-5C₂₃H₂₇N₃O₄

1-[3-(Dimethylamino)propyl]-4-(2,5-dimethylbenzoyl)-3-hydroxy-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27N3O3

1-[3-(Dimethylamino)propyl]-4-(2,5-dimethylbenzoyl)-3-hydroxy-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₃H₂₇N₃O₃

4-(2,5-Dimethylbenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C21H22N2O4

4-(2,5-Dimethylbenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₁H₂₂N₂O₄