Murcko scaffold
Ring system with 3 rings and 20 atoms
95 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 20
- Chemicals
- 95
- With full pages
- 15
Scaffold SMILES
O=C1NC(c2cccnc2)C(=Cc2ccccc2)C1=O
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 95 chemicals
![1-[3-(Diethylamino)propyl]-4-(2,5-dimethylbenzoyl)-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H31N3O3](/s/UGNKZLOURSDESH-UHFFFAOYSA-N.svg)
1-[3-(Diethylamino)propyl]-4-(2,5-dimethylbenzoyl)-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C25H31N3O3
![1-[3-(Dimethylamino)propyl]-4-(2,5-dimethylbenzoyl)-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27N3O3](/s/ZFTWOEGAIHXURK-UHFFFAOYSA-N.svg)
1-[3-(Dimethylamino)propyl]-4-(2,5-dimethylbenzoyl)-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C23H27N3O3
![1-[2-(Diethylamino)ethyl]-3-hydroxy-4-(4-methylbenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27N3O3](/s/NWPTWSDWUZAHNX-UHFFFAOYSA-N.svg)
1-[2-(Diethylamino)ethyl]-3-hydroxy-4-(4-methylbenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C23H27N3O3
![3-Hydroxy-1-(2-methoxyethyl)-4-[4-(propan-2-yloxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H24N2O5](/s/AUCCQBXUTLAVPA-UHFFFAOYSA-N.svg)
3-Hydroxy-1-(2-methoxyethyl)-4-[4-(propan-2-yloxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C22H24N2O5
![3-Hydroxy-1-(2-methoxyethyl)-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H22N2O5](/s/CNVDISPGMYMEGN-UHFFFAOYSA-N.svg)
3-Hydroxy-1-(2-methoxyethyl)-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C22H22N2O5
3-Hydroxy-1-(2-methoxyethyl)-4-(4-propoxybenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C22H24N2O5
![3-Hydroxy-1-(2-methoxyethyl)-4-[4-(2-methylpropoxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H26N2O5](/s/QTQQLLWHIICSKT-UHFFFAOYSA-N.svg)
3-Hydroxy-1-(2-methoxyethyl)-4-[4-(2-methylpropoxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C23H26N2O5
![4-[Hydroxy-(4-propoxyphenyl)methylidene]-1-(3-methoxypropyl)-5-pyridin-3-ylpyrrolidine-2,3-dione chemical structure, C23H26N2O5](/s/RMAHHBKXULHLJX-UHFFFAOYSA-N.svg)
4-[Hydroxy-(4-propoxyphenyl)methylidene]-1-(3-methoxypropyl)-5-pyridin-3-ylpyrrolidine-2,3-dione
C23H26N2O5
![4-[Hydroxy-(4-methoxy-2-methylphenyl)methylidene]-1-(3-methoxypropyl)-5-pyridin-3-ylpyrrolidine-2,3-dione chemical structure, C22H24N2O5](/s/XWDPLNYEMFBGOO-UHFFFAOYSA-N.svg)
4-[Hydroxy-(4-methoxy-2-methylphenyl)methylidene]-1-(3-methoxypropyl)-5-pyridin-3-ylpyrrolidine-2,3-dione
C22H24N2O5
![1-[3-(Dimethylamino)propyl]-3-hydroxy-4-(4-methoxy-2-methylbenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27N3O4](/s/SWAZLRNZAPGKCG-UHFFFAOYSA-N.svg)
1-[3-(Dimethylamino)propyl]-3-hydroxy-4-(4-methoxy-2-methylbenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C23H27N3O4
![1-[3-(Dimethylamino)propyl]-3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27N3O4](/s/AIBXOZWYBQIFDY-UHFFFAOYSA-N.svg)
1-[3-(Dimethylamino)propyl]-3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C23H27N3O4
![1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H25N3O4](/s/MXKRCSRERBEHJN-UHFFFAOYSA-N.svg)
1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C22H25N3O4
![1-[2-(Diethylamino)ethyl]-3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H29N3O4](/s/FXYFBUNXQHUBFJ-UHFFFAOYSA-N.svg)
1-[2-(Diethylamino)ethyl]-3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C24H29N3O4
![1-[3-(Dimethylamino)propyl]-3-hydroxy-4-[3-methyl-4-(2-methylpropoxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H33N3O4](/s/HBFCXNUOSIWKAC-UHFFFAOYSA-N.svg)
1-[3-(Dimethylamino)propyl]-3-hydroxy-4-[3-methyl-4-(2-methylpropoxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C26H33N3O4
3-(3-Hydroxy-4-(4-methoxybenzoyl)-2-oxo-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid
CAS 442640-86-0C20H18N2O6
![1-[3-(Dimethylamino)propyl]-4-(3-ethoxybenzoyl)-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27N3O4, CAS 608498-55-1](/s/ZRWYSTGMSGKTBU-UHFFFAOYSA-N.svg)
1-[3-(Dimethylamino)propyl]-4-(3-ethoxybenzoyl)-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 608498-55-1C23H27N3O4
3-Hydroxy-4-(3-methoxybenzoyl)-1-(2-methoxyethyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 608499-84-9C20H20N2O5
![4-[(3-Ethoxyphenyl)-hydroxymethylidene]-1-(2-methoxyethyl)-5-pyridin-3-ylpyrrolidine-2,3-dione chemical structure, C21H22N2O5](/s/ZFGLOJJVTSSRMD-UHFFFAOYSA-N.svg)
4-[(3-Ethoxyphenyl)-hydroxymethylidene]-1-(2-methoxyethyl)-5-pyridin-3-ylpyrrolidine-2,3-dione
C21H22N2O5
3-Hydroxy-1-(2-methoxyethyl)-4-(3-propoxybenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 608500-70-5C22H24N2O5
3-Hydroxy-4-(3-methoxybenzoyl)-1-(3-methoxypropyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 608501-56-0C21H22N2O5
![1-[2-(Dimethylamino)ethyl]-4-(3-ethoxybenzoyl)-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H25N3O4, CAS 608503-73-7](/s/RMTBXNZQPZUPLZ-UHFFFAOYSA-N.svg)
1-[2-(Dimethylamino)ethyl]-4-(3-ethoxybenzoyl)-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 608503-73-7C22H25N3O4
![1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-(3-propoxybenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27N3O4, CAS 608504-17-2](/s/SOXGFONTTZDEOJ-UHFFFAOYSA-N.svg)
1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-(3-propoxybenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 608504-17-2C23H27N3O4
![1-[2-(Diethylamino)ethyl]-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27N3O4, CAS 608508-51-6](/s/FRQIQARZBSUMCP-UHFFFAOYSA-N.svg)
1-[2-(Diethylamino)ethyl]-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 608508-51-6C23H27N3O4
4-(2,5-Dimethylbenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 607690-08-4C21H22N2O4
- 4-(2,5-Dimethylbenzoyl)-3-hydroxy-1-(3-methoxypropyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-oneC22H24N2O4
- 1-[2-(Diethylamino)ethyl]-4-(2,5-dimethylbenzoyl)-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one609328-27-0C24H29N3O3
- 1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-[4-(2-methylpropoxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-oneC24H29N3O4
- 4-(4-Butoxy-3-methylbenzoyl)-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-oneC25H31N3O4
- 4-(4-Butoxybenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-oneC23H26N2O5
- 1-[3-(Dimethylamino)propyl]-3-hydroxy-4-[4-(2-methylpropoxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-oneC25H31N3O4
- 1-[2-(Diethylamino)ethyl]-4-(3,4-dimethoxybenzoyl)-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-oneC24H29N3O5
- 1-[2-(Diethylamino)ethyl]-3-hydroxy-4-[(4-methylphenyl)carbonyl]-5-(3-pyridyl)-3-pyrrolin-2-one615274-24-3C23H27N3O3
- (4E)-4-{Hydroxy[4-(propan-2-yloxy)phenyl]methylidene}-1-(2-methoxyethyl)-5-(pyridin-3-yl)pyrrolidine-2,3-dione845668-45-3C22H24N2O5
- (4E)-4-{Hydroxy[4-(prop-2-en-1-yloxy)phenyl]methylidene}-1-(2-methoxyethyl)-5-(pyridin-3-yl)pyrrolidine-2,3-dione846583-13-9C22H22N2O5
- (4E)-4-{Hydroxy[4-(2-methylpropoxy)phenyl]methylidene}-1-(2-methoxyethyl)-5-(pyridin-3-yl)pyrrolidine-2,3-dione847856-01-3C23H26N2O5
- 3-Hydroxy-4-(4-methoxy-2-methylbenzoyl)-1-(3-methoxypropyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one459793-68-1C22H24N2O5
- 4-(4-Chlorobenzoyl)-1-(3-(dimethylamino)propyl)-3-hydroxy-5-(pyridin-3-yl)-1H-pyrrol-2(5H)-one380158-61-2C21H22ClN3O3
- 1-[3-(Dimethylamino)propyl]-4-(4-fluorobenzoyl)-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one381175-17-3C21H22FN3O3
- 4-(4-Bromobenzoyl)-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one380583-43-7C21H22BrN3O3
- 4-{1-[2-(Dimethylamino)ethyl]-4-hydroxy-5-oxo-2-(pyridin-3-yl)-2,5-dihydro-1H-pyrrole-3-carbonyl}-N,N-dimethylbenzene-1-sulfonamide431984-15-5C22H26N4O5S
- 1-(2-(Dimethylamino)ethyl)-3-hydroxy-4-(4-isobutoxy-2-methylbenzoyl)-5-(pyridin-3-yl)-1H-pyrrol-2(5H)-one433246-26-5C25H31N3O4
- 3-Hydroxy-4-(4-methoxy-3-methylbenzoyl)-1-(2-methoxyethyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one433248-34-1C21H22N2O5
- 3-Hydroxy-4-(4-methoxy-2-methylbenzoyl)-1-(2-methoxyethyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one385421-19-2C21H22N2O5
- 3-Hydroxy-4-(4-isopropoxy-3-methylbenzoyl)-1-(2-methoxyethyl)-5-(3-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one609797-18-4C23H26N2O5
- 1-[3-(Dimethylamino)propyl]-3-hydroxy-4-[3-methyl-4-(propan-2-yloxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one510712-14-8C25H31N3O4
- 1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-[3-methyl-4-(2-methylpropoxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one433260-36-7C25H31N3O4
- (4E)-1-[2-(Diethylamino)ethyl]-4-{hydroxy[4-(propan-2-yloxy)phenyl]methylidene}-5-(pyridin-3-yl)pyrrolidine-2,3-dione385420-19-9C25H31N3O4
- 1-(2-(Diethylamino)ethyl)-3-hydroxy-4-(4-methoxy-2-methylbenzoyl)-5-(pyridin-3-yl)-1H-pyrrol-2(5H)-one385387-34-8C24H29N3O4
Related scaffolds
Same ring framework with different atoms or bond orders
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