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Murcko scaffold

Ring system with 3 rings and 20 atoms

48 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
48
With full pages
3
Scaffold SMILES

O=C(Nc1ccccc1)c1cnc(-c2ccccc2)s1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1cnc(-c2ccccc2)s1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 48 chemicals

N-(4-Chlorophenyl)-4-methyl-2-(4-methylphenyl)-1,3-thiazole-5-carboxamide chemical structure, C18H15ClN2OS, CAS 198711-14-7
N-(4-Chlorophenyl)-4-methyl-2-(4-methylphenyl)-1,3-thiazole-5-carboxamide
CAS 198711-14-7C18H15ClN2OS
4-Methyl-N,2-diphenyl-1,3-thiazole-5-carboxamide chemical structure, C17H14N2OS, CAS 53040-11-2
4-Methyl-N,2-diphenyl-1,3-thiazole-5-carboxamide
CAS 53040-11-2C17H14N2OS
4-Methyl-N-(3-methylphenyl)-2-phenyl-1,3-thiazole-5-carboxamide chemical structure, C18H16N2OS, CAS 397284-61-6
4-Methyl-N-(3-methylphenyl)-2-phenyl-1,3-thiazole-5-carboxamide
CAS 397284-61-6C18H16N2OS
N-(3-Methoxyphenyl)-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide chemical structure, C18H16N2O2S, CAS 397284-65-0
N-(3-Methoxyphenyl)-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide
CAS 397284-65-0C18H16N2O2S
N-(4-Chlorophenyl)-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide chemical structure, C17H13ClN2OS, CAS 38769-53-8
N-(4-Chlorophenyl)-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide
CAS 38769-53-8C17H13ClN2OS
N-(4-Chlorophenyl)-2-(3,4-dimethoxyphenyl)-4-methyl-1,3-thiazole-5-carboxamide chemical structure, C19H17ClN2O3S, CAS 400080-50-4
N-(4-Chlorophenyl)-2-(3,4-dimethoxyphenyl)-4-methyl-1,3-thiazole-5-carboxamide
CAS 400080-50-4C19H17ClN2O3S
N-(3,4-Dichlorophenyl)-2-(3,4-dimethoxyphenyl)-4-methyl-1,3-thiazole-5-carboxamide chemical structure, C19H16Cl2N2O3S, CAS 400080-51-5
N-(3,4-Dichlorophenyl)-2-(3,4-dimethoxyphenyl)-4-methyl-1,3-thiazole-5-carboxamide
CAS 400080-51-5C19H16Cl2N2O3S
2-(3,4-Dimethoxyphenyl)-4-methyl-N-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide chemical structure, C20H17F3N2O3S, CAS 400080-52-6
2-(3,4-Dimethoxyphenyl)-4-methyl-N-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide
CAS 400080-52-6C20H17F3N2O3S
N-(4-Fluorophenyl)-2-phenyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide chemical structure, C17H10F4N2OS, CAS 400080-74-2
N-(4-Fluorophenyl)-2-phenyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide
CAS 400080-74-2C17H10F4N2OS
N-(2,4-Difluorophenyl)-2-phenyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide chemical structure, C17H9F5N2OS, CAS 400080-75-3
N-(2,4-Difluorophenyl)-2-phenyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide
CAS 400080-75-3C17H9F5N2OS
2-(4-Chlorophenyl)-4-methyl-N-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide chemical structure, C18H12ClF3N2OS, CAS 320420-80-2
2-(4-Chlorophenyl)-4-methyl-N-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide
CAS 320420-80-2C18H12ClF3N2OS
N-(3,4-Dichlorophenyl)-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide chemical structure, C17H12Cl2N2OS, CAS 38769-46-9
N-(3,4-Dichlorophenyl)-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide
CAS 38769-46-9C17H12Cl2N2OS
4-Methyl-2-phenyl-N-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxamide chemical structure, C18H13F3N2O2S, CAS 320420-93-7
4-Methyl-2-phenyl-N-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxamide
CAS 320420-93-7C18H13F3N2O2S
4-Methyl-N,2-bis[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide chemical structure, C19H12F6N2OS, CAS 320420-95-9
4-Methyl-N,2-bis[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide
CAS 320420-95-9C19H12F6N2OS
N-(2,4-Difluorophenyl)-4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide chemical structure, C18H11F5N2OS, CAS 320420-97-1
N-(2,4-Difluorophenyl)-4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide
CAS 320420-97-1C18H11F5N2OS
N-(3,5-Dichlorophenyl)-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide chemical structure, C17H12Cl2N2OS, CAS 321429-65-6
N-(3,5-Dichlorophenyl)-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide
CAS 321429-65-6C17H12Cl2N2OS
N-(2,4-Difluorophenyl)-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide chemical structure, C17H12F2N2OS, CAS 303997-94-6
N-(2,4-Difluorophenyl)-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide
CAS 303997-94-6C17H12F2N2OS
4-Methyl-2-phenyl-N-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide chemical structure, C18H13F3N2OS, CAS 38769-47-0
4-Methyl-2-phenyl-N-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide
CAS 38769-47-0C18H13F3N2OS
4-Methyl-2-phenyl-N-(4-sulfamoylphenyl)thiazole-5-carboxamide chemical structure, C17H15N3O3S2, CAS 708988-21-0
4-Methyl-2-phenyl-N-(4-sulfamoylphenyl)thiazole-5-carboxamide
CAS 708988-21-0C17H15N3O3S2
2-Phenyl-4-(trifluoromethyl)-N-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide chemical structure, C18H10F6N2OS, CAS 400080-76-4
2-Phenyl-4-(trifluoromethyl)-N-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide
CAS 400080-76-4C18H10F6N2OS
N-(3,5-Dichlorophenyl)-4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide chemical structure, C18H11Cl2F3N2OS, CAS 321429-63-4
N-(3,5-Dichlorophenyl)-4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide
CAS 321429-63-4C18H11Cl2F3N2OS
4-Methyl-N-(3-nitrophenyl)-2-phenyl-1,3-thiazole-5-carboxamide chemical structure, C17H13N3O3S, CAS 477488-99-6
4-Methyl-N-(3-nitrophenyl)-2-phenyl-1,3-thiazole-5-carboxamide
CAS 477488-99-6C17H13N3O3S
N-(2-Ethoxyphenyl)-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide chemical structure, C19H18N2O2S, CAS 892362-54-8
N-(2-Ethoxyphenyl)-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide
CAS 892362-54-8C19H18N2O2S
N-(2,4-Dimethoxyphenyl)-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide chemical structure, C19H18N2O3S, CAS 892359-55-6
N-(2,4-Dimethoxyphenyl)-4-methyl-2-phenyl-1,3-thiazole-5-carboxamide
CAS 892359-55-6C19H18N2O3S