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Murcko scaffold

Ring system with 3 rings and 19 atoms

30 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
30
With full pages
6
Scaffold SMILES

O=C1ON=C(c2ccccc2)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1ON=C(c2ccccc2)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 30 of 30 chemicals

(4Z)-4-[(2,4-Dimethoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one chemical structure, C18H15NO4, CAS 153390-66-0
(4Z)-4-[(2,4-Dimethoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one
CAS 153390-66-0C18H15NO4
(4Z)-4-[(4-Methoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one chemical structure, C17H13NO3, CAS 50779-89-0
(4Z)-4-[(4-Methoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one
CAS 50779-89-0C17H13NO3
4-[(2-Hydroxyphenyl)methylene]-3-(4-nitrophenyl)isoxazol-5-one chemical structure, C16H10N2O5, CAS 328276-67-1
4-[(2-Hydroxyphenyl)methylene]-3-(4-nitrophenyl)isoxazol-5-one
CAS 328276-67-1C16H10N2O5
(4Z)-4-[(4-Hydroxy-3-methoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one chemical structure, C17H13NO4, CAS 1241046-32-1
(4Z)-4-[(4-Hydroxy-3-methoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one
CAS 1241046-32-1C17H13NO4
(4E)-4-[(2,4-Diethoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one chemical structure, C20H19NO4, CAS 357647-42-8
(4E)-4-[(2,4-Diethoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one
CAS 357647-42-8C20H19NO4
(4E)-4-[(2,3-Dimethoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one chemical structure, C18H15NO4, CAS 357647-46-2
(4E)-4-[(2,3-Dimethoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one
CAS 357647-46-2C18H15NO4
(4E)-4-[(4-Ethoxy-3-methoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one chemical structure, C19H17NO4, CAS 690990-95-5
(4E)-4-[(4-Ethoxy-3-methoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one
CAS 690990-95-5C19H17NO4
5(4H)-Isoxazolone, 4-[(3-hydroxyphenyl)methylene]-3-phenyl- chemical structure, C16H11NO3, CAS 54754-44-8
5(4H)-Isoxazolone, 4-[(3-hydroxyphenyl)methylene]-3-phenyl-
CAS 54754-44-8C16H11NO3
3-{3-Nitrophenyl}-4-(2-methoxybenzylidene)-5(4H)-isoxazolone chemical structure, C17H12N2O5, CAS 360764-22-3
3-{3-Nitrophenyl}-4-(2-methoxybenzylidene)-5(4H)-isoxazolone
CAS 360764-22-3C17H12N2O5
4-(2,5-Dimethylbenzylidene)-3-phenyl-5(4H)-isoxazolone chemical structure, C18H15NO2, CAS 350511-85-2
4-(2,5-Dimethylbenzylidene)-3-phenyl-5(4H)-isoxazolone
CAS 350511-85-2C18H15NO2
4-(3,4-Dimethoxy-benzylidene)-3-phenyl-4H-isoxazol-5-one chemical structure, C18H15NO4, CAS 1164546-98-8
4-(3,4-Dimethoxy-benzylidene)-3-phenyl-4H-isoxazol-5-one
CAS 1164546-98-8C18H15NO4
(4Z)-4-[(3,4-Dimethoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one chemical structure, C18H15NO4, CAS 153390-65-9
(4Z)-4-[(3,4-Dimethoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one
CAS 153390-65-9C18H15NO4
(4Z)-4-[4-(Dimethylamino)benzylidene]-3-phenyl-1,2-oxazol-5(4H)-one chemical structure, C18H16N2O2, CAS 155527-97-2
(4Z)-4-[4-(Dimethylamino)benzylidene]-3-phenyl-1,2-oxazol-5(4H)-one
CAS 155527-97-2C18H16N2O2
4-Benzylidene-3-phenyl-4H-isoxazol-5-one chemical structure, C16H11NO2, CAS 1088-32-0
4-Benzylidene-3-phenyl-4H-isoxazol-5-one
CAS 1088-32-0C16H11NO2
(4E)-3-(4-Chlorophenyl)-4-[(3-ethoxy-4-methoxyphenyl)methylidene]-1,2-oxazol-5-one chemical structure, C19H16ClNO4, CAS 341949-31-3
(4E)-3-(4-Chlorophenyl)-4-[(3-ethoxy-4-methoxyphenyl)methylidene]-1,2-oxazol-5-one
CAS 341949-31-3C19H16ClNO4
(4Z)-4-[[4-Methoxy-3-(2,2,2-trifluoroethoxymethyl)phenyl]methylidene]-3-phenyl-1,2-oxazol-5-one chemical structure, C20H16F3NO4, CAS 352683-67-1
(4Z)-4-[[4-Methoxy-3-(2,2,2-trifluoroethoxymethyl)phenyl]methylidene]-3-phenyl-1,2-oxazol-5-one
CAS 352683-67-1C20H16F3NO4
(4Z)-4-(5-Bromo-2-methoxybenzylidene)-3-phenyl-1,2-oxazol-5(4H)-one chemical structure, C17H12BrNO3, CAS 672893-25-3
(4Z)-4-(5-Bromo-2-methoxybenzylidene)-3-phenyl-1,2-oxazol-5(4H)-one
CAS 672893-25-3C17H12BrNO3
(4E)-4-[(2-Hexoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one chemical structure, C22H23NO3, CAS 296770-09-7
(4E)-4-[(2-Hexoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one
CAS 296770-09-7C22H23NO3
(4Z)-4-[2-(Heptyloxy)benzylidene]-3-phenyl-1,2-oxazol-5(4H)-one chemical structure, C23H25NO3, CAS 312268-23-8
(4Z)-4-[2-(Heptyloxy)benzylidene]-3-phenyl-1,2-oxazol-5(4H)-one
CAS 312268-23-8C23H25NO3
(4E)-4-(3-Hydroxybenzylidene)-3-phenyl-1,2-oxazol-5(4H)-one chemical structure, C16H11NO3, CAS 5961-29-5
(4E)-4-(3-Hydroxybenzylidene)-3-phenyl-1,2-oxazol-5(4H)-one
CAS 5961-29-5C16H11NO3
4-Benzylidene-3-(4-methylphenyl)-5(4H)-isoxazolone chemical structure, C17H13NO2, CAS 1227841-50-0
4-Benzylidene-3-(4-methylphenyl)-5(4H)-isoxazolone
CAS 1227841-50-0C17H13NO2
(4E)-4-[(4-Hexoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one chemical structure, C22H23NO3, CAS 351995-21-6
(4E)-4-[(4-Hexoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one
CAS 351995-21-6C22H23NO3
(4E)-3-(4-Chlorophenyl)-4-[(2-prop-2-enoxyphenyl)methylidene]-1,2-oxazol-5-one chemical structure, C19H14ClNO3, CAS 296801-24-6
(4E)-3-(4-Chlorophenyl)-4-[(2-prop-2-enoxyphenyl)methylidene]-1,2-oxazol-5-one
CAS 296801-24-6C19H14ClNO3
2-[2-Ethoxy-4-[(5-oxo-3-phenyl-4(5H)-isoxazolylidene)methyl]phenoxy]acetonitrile chemical structure, C20H16N2O4, CAS 445416-62-6
2-[2-Ethoxy-4-[(5-oxo-3-phenyl-4(5H)-isoxazolylidene)methyl]phenoxy]acetonitrile
CAS 445416-62-6C20H16N2O4