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Murcko scaffold

2-Pyrrolidinone, 4-(morpholinocarbonyl)-1-phenyl- scaffold

16 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
16
With full pages
8
Scaffold SMILES

O=C(C1CC(=O)N(c2ccccc2)C1)N1CCOCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Pyrrolidinone, 4-(morpholinocarbonyl)-1-phenyl- page
Murcko scaffold O=C(C1CC(=O)N(c2ccccc2)C1)N1CCOCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

Benzoic acid, o-(4-morpholinocarbonyl-2-oxo-1-pyrrolidinyl)-, methyl ester chemical structure, C17H20N2O5, CAS 39630-20-1
Benzoic acid, o-(4-morpholinocarbonyl-2-oxo-1-pyrrolidinyl)-, methyl ester
CAS 39630-20-1C17H20N2O5
2-Pyrrolidinone, 4-(morpholinocarbonyl)-1-phenyl- chemical structure, C15H18N2O3, CAS 39629-99-7
2-Pyrrolidinone, 4-(morpholinocarbonyl)-1-phenyl-
CAS 39629-99-7C15H18N2O3
1-(4-Chlorophenyl)-4-(morpholine-4-carbonyl)pyrrolidin-2-one chemical structure, C15H17ClN2O3, CAS 39630-16-5
1-(4-Chlorophenyl)-4-(morpholine-4-carbonyl)pyrrolidin-2-one
CAS 39630-16-5C15H17ClN2O3
1-(4-Methoxyphenyl)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-one chemical structure, C16H20N2O4, CAS 878426-38-1
1-(4-Methoxyphenyl)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-one
CAS 878426-38-1C16H20N2O4
1-(2-Ethoxyphenyl)-4-(morpholine-4-carbonyl)pyrrolidin-2-one chemical structure, C17H22N2O4, CAS 873565-41-4
1-(2-Ethoxyphenyl)-4-(morpholine-4-carbonyl)pyrrolidin-2-one
CAS 873565-41-4C17H22N2O4
1-(4-Fluorophenyl)-4-(morpholine-4-carbonyl)pyrrolidin-2-one chemical structure, C15H17FN2O3, CAS 878430-35-4
1-(4-Fluorophenyl)-4-(morpholine-4-carbonyl)pyrrolidin-2-one
CAS 878430-35-4C15H17FN2O3
1-(3,4-Dimethylphenyl)-4-(morpholine-4-carbonyl)pyrrolidin-2-one chemical structure, C17H22N2O3, CAS 887676-73-5
1-(3,4-Dimethylphenyl)-4-(morpholine-4-carbonyl)pyrrolidin-2-one
CAS 887676-73-5C17H22N2O3
1-(3-Chloro-4-methylphenyl)-4-(morpholine-4-carbonyl)pyrrolidin-2-one chemical structure, C16H19ClN2O3, CAS 887674-80-8
1-(3-Chloro-4-methylphenyl)-4-(morpholine-4-carbonyl)pyrrolidin-2-one
CAS 887674-80-8C16H19ClN2O3
1-(4-Chlorophenyl)-4-(2,6-dimethylmorpholine-4-carbonyl)pyrrolidin-2-one chemical structure, C17H21ClN2O3, CAS 1005275-31-9
1-(4-Chlorophenyl)-4-(2,6-dimethylmorpholine-4-carbonyl)pyrrolidin-2-one
CAS 1005275-31-9C17H21ClN2O3
4-[(2,6-Dimethylmorpholin-4-yl)carbonyl]-1-(2-methylphenyl)pyrrolidin-2-one chemical structure, C18H24N2O3, CAS 1005288-44-7
4-[(2,6-Dimethylmorpholin-4-yl)carbonyl]-1-(2-methylphenyl)pyrrolidin-2-one
CAS 1005288-44-7C18H24N2O3
1-(3-Methoxyphenyl)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-one chemical structure, C16H20N2O4, CAS 924965-37-7
1-(3-Methoxyphenyl)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-one
CAS 924965-37-7C16H20N2O4
1-(2,5-Dimethoxyphenyl)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-one chemical structure, C17H22N2O5, CAS 924970-43-4
1-(2,5-Dimethoxyphenyl)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-one
CAS 924970-43-4C17H22N2O5
N-(4-{4-[(2,6-Dimethylmorpholin-4-yl)carbonyl]-2-oxopyrrolidin-1-yl}phenyl)acetamide chemical structure, C19H25N3O4, CAS 1005056-87-0
N-(4-{4-[(2,6-Dimethylmorpholin-4-yl)carbonyl]-2-oxopyrrolidin-1-yl}phenyl)acetamide
CAS 1005056-87-0C19H25N3O4
1-(2-Ethylphenyl)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-one chemical structure, C17H22N2O3, CAS 903018-40-6
1-(2-Ethylphenyl)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-one
CAS 903018-40-6C17H22N2O3
1-(2-Methoxy-5-methylphenyl)-4-(4-morpholinylcarbonyl)-2-pyrrolidinone chemical structure, C17H22N2O4, CAS 925889-70-9
1-(2-Methoxy-5-methylphenyl)-4-(4-morpholinylcarbonyl)-2-pyrrolidinone
CAS 925889-70-9C17H22N2O4
4-[1-(2-Fluorophenyl)-5-oxopyrrolidine-3-carbonyl]morpholine-3-carbonitrile chemical structure, C16H16FN3O3, CAS 2135201-97-5
4-[1-(2-Fluorophenyl)-5-oxopyrrolidine-3-carbonyl]morpholine-3-carbonitrile
CAS 2135201-97-5C16H16FN3O3