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Murcko scaffold

Ring system with 4 rings and 25 atoms

18 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
18
With full pages
2
Scaffold SMILES

O=c1c2ccccc2nc(C=Cc2cccnc2)n1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c2ccccc2nc(C=Cc2cccnc2)n1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

3-(4-Chlorophenyl)-6-iodo-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one chemical structure, C21H13ClIN3O, CAS 695220-13-4
3-(4-Chlorophenyl)-6-iodo-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one
CAS 695220-13-4C21H13ClIN3O
3-Phenyl-2-[(E)-2-(pyridin-3-yl)ethenyl]quinazolin-4(3H)-one chemical structure, C21H15N3O, CAS 1237744-56-7
3-Phenyl-2-[(E)-2-(pyridin-3-yl)ethenyl]quinazolin-4(3H)-one
CAS 1237744-56-7C21H15N3O
RefChem:382051 chemical structure, C22H17N3O2, CAS 5903-60-6
RefChem:382051
CAS 5903-60-6C22H17N3O2
Src 909 chemical structure, C22H17N3O, CAS 1897-90-1
Src 909
CAS 1897-90-1C22H17N3O
3-(4-Methylphenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one chemical structure, C22H17N3O, CAS 1290541-61-5
3-(4-Methylphenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one
CAS 1290541-61-5C22H17N3O
3-(4-Methoxyphenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one chemical structure, C22H17N3O2, CAS 41466-21-1
3-(4-Methoxyphenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one
CAS 41466-21-1C22H17N3O2
3-(4-Nitrophenyl)-2-[(E)-2-(pyridin-3-yl)ethenyl]quinazolin-4(3H)-one chemical structure, C21H14N4O3, CAS 334505-36-1
3-(4-Nitrophenyl)-2-[(E)-2-(pyridin-3-yl)ethenyl]quinazolin-4(3H)-one
CAS 334505-36-1C21H14N4O3
3-(4-Bromophenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one chemical structure, C21H14BrN3O, CAS 380879-59-4
3-(4-Bromophenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one
CAS 380879-59-4C21H14BrN3O
3-(2-Chlorophenyl)-6-iodo-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one chemical structure, C21H13ClIN3O, CAS 692268-95-4
3-(2-Chlorophenyl)-6-iodo-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one
CAS 692268-95-4C21H13ClIN3O
(E)-6-Iodo-3-(3-nitrophenyl)-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one chemical structure, C21H13IN4O3, CAS 1237744-66-9
(E)-6-Iodo-3-(3-nitrophenyl)-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one
CAS 1237744-66-9C21H13IN4O3
6-Iodo-3-(3-methoxyphenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one chemical structure, C22H16IN3O2, CAS 1237744-60-3
6-Iodo-3-(3-methoxyphenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one
CAS 1237744-60-3C22H16IN3O2
6-Iodo-3-(4-nitrophenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one chemical structure, C21H13IN4O3, CAS 1237744-65-8
6-Iodo-3-(4-nitrophenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one
CAS 1237744-65-8C21H13IN4O3
6-Iodo-3-(2-nitrophenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one chemical structure, C21H13IN4O3, CAS 1237744-67-0
6-Iodo-3-(2-nitrophenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one
CAS 1237744-67-0C21H13IN4O3
6-Iodo-3-(2-methylphenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one chemical structure, C22H16IN3O, CAS 1237744-64-7
6-Iodo-3-(2-methylphenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one
CAS 1237744-64-7C22H16IN3O
3-(2,6-Dichlorophenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one chemical structure, C21H13Cl2N3O, CAS 500275-56-9
3-(2,6-Dichlorophenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one
CAS 500275-56-9C21H13Cl2N3O
3-(4-Hydroxyphenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one chemical structure, C21H15N3O2, CAS 381197-30-4
3-(4-Hydroxyphenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one
CAS 381197-30-4C21H15N3O2
4(3H)-Quinazolinone, 3-(2-chlorophenyl)-2-(2-(3-pyridyl)ethenyl)- chemical structure, C21H14ClN3O, CAS 1897-91-2
4(3H)-Quinazolinone, 3-(2-chlorophenyl)-2-(2-(3-pyridyl)ethenyl)-
CAS 1897-91-2C21H14ClN3O
4(3H)-Quinazolinone, 3-(2-methylphenyl)-2-(2-(6-methyl-3-pyridyl)ethenyl)- chemical structure, C23H19N3O, CAS 78308-57-3
4(3H)-Quinazolinone, 3-(2-methylphenyl)-2-(2-(6-methyl-3-pyridyl)ethenyl)-
CAS 78308-57-3C23H19N3O