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Murcko scaffold

Ring system with 4 rings and 25 atoms

275 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
275
With full pages
26
Scaffold SMILES

O=c1c2ccccc2nc(C=Cc2ccccc2)n1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c2ccccc2nc(C=Cc2ccccc2)n1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 275 chemicals

2-[2-(4-Chlorophenyl)ethenyl]-3-phenyl-4(3H)-quinazolinone chemical structure, C22H15ClN2O, CAS 17776-71-5
2-[2-(4-Chlorophenyl)ethenyl]-3-phenyl-4(3H)-quinazolinone
CAS 17776-71-5C22H15ClN2O
2-(5-Bromo-2-hydroxystyryl)-3-(m-tolyl)quinazolin-4(3H)-one chemical structure, C23H17BrN2O2
2-(5-Bromo-2-hydroxystyryl)-3-(m-tolyl)quinazolin-4(3H)-one
C23H17BrN2O2
2-(4-Hydroxy-3-methoxystyryl)-3-(p-tolyl)quinazolin-4(3H)-one chemical structure, C24H20N2O3
2-(4-Hydroxy-3-methoxystyryl)-3-(p-tolyl)quinazolin-4(3H)-one
C24H20N2O3
2-(4-Chlorostyryl)-3-(2-methoxyphenyl)quinazolin-4(3H)-one chemical structure, C23H17ClN2O2
2-(4-Chlorostyryl)-3-(2-methoxyphenyl)quinazolin-4(3H)-one
C23H17ClN2O2
4(3H)-Quinazolinone, 3-(4-hydroxyphenyl)-2-(2-phenylethenyl)- chemical structure, C22H16N2O2, CAS 112750-80-8
4(3H)-Quinazolinone, 3-(4-hydroxyphenyl)-2-(2-phenylethenyl)-
CAS 112750-80-8C22H16N2O2
2-(4-Hydroxy-3-methoxystyryl)-3-(4-hydroxyphenyl)quinazolin-4(3H)-one chemical structure, C23H18N2O4, CAS 112750-92-2
2-(4-Hydroxy-3-methoxystyryl)-3-(4-hydroxyphenyl)quinazolin-4(3H)-one
CAS 112750-92-2C23H18N2O4
4-(4-Oxo-2-styrylquinazolin-3(4H)-yl)benzoic acid chemical structure, C23H16N2O3
4-(4-Oxo-2-styrylquinazolin-3(4H)-yl)benzoic acid
C23H16N2O3
2-(3-Bromostyryl)-3-(p-tolyl)quinazolin-4(3H)-one chemical structure, C23H17BrN2O
2-(3-Bromostyryl)-3-(p-tolyl)quinazolin-4(3H)-one
C23H17BrN2O
2-(3-Bromostyryl)-3-(2-hydroxyphenyl)quinazolin-4(3H)-one chemical structure, C22H15BrN2O2
2-(3-Bromostyryl)-3-(2-hydroxyphenyl)quinazolin-4(3H)-one
C22H15BrN2O2
6-Iodo-2-(4-methoxystyryl)-3-(o-tolyl)quinazolin-4(3H)-one chemical structure, C24H19IN2O2
6-Iodo-2-(4-methoxystyryl)-3-(o-tolyl)quinazolin-4(3H)-one
C24H19IN2O2
2-(2-Chlorostyryl)-6-iodo-3-phenylquinazolin-4(3H)-one chemical structure, C22H14ClIN2O, CAS 381209-48-9
2-(2-Chlorostyryl)-6-iodo-3-phenylquinazolin-4(3H)-one
CAS 381209-48-9C22H14ClIN2O
2-(4-Fluorostyryl)-6-iodo-3-(3-methoxyphenyl)quinazolin-4(3H)-one chemical structure, C23H16FIN2O2
2-(4-Fluorostyryl)-6-iodo-3-(3-methoxyphenyl)quinazolin-4(3H)-one
C23H16FIN2O2
6-Iodo-2-(4-methylstyryl)-3-(p-tolyl)quinazolin-4(3H)-one chemical structure, C24H19IN2O
6-Iodo-2-(4-methylstyryl)-3-(p-tolyl)quinazolin-4(3H)-one
C24H19IN2O
6-Iodo-3-(2-methoxyphenyl)-2-(2-methylstyryl)quinazolin-4(3H)-one chemical structure, C24H19IN2O2
6-Iodo-3-(2-methoxyphenyl)-2-(2-methylstyryl)quinazolin-4(3H)-one
C24H19IN2O2
Benzoic acid, 4-[6-iodo-2-[(1E)-2-(4-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]- chemical structure, C23H14IN3O5, CAS 1237744-39-6
Benzoic acid, 4-[6-iodo-2-[(1E)-2-(4-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-
CAS 1237744-39-6C23H14IN3O5
3-Phenyl-2-(2,4,5-trimethoxystyryl)quinazolin-4(3H)-one chemical structure, C25H22N2O4, CAS 331261-53-1
3-Phenyl-2-(2,4,5-trimethoxystyryl)quinazolin-4(3H)-one
CAS 331261-53-1C25H22N2O4
2-(2,4-Dichlorostyryl)-3-(3-(trifluoromethyl)phenyl)quinazolin-4(3H)-one chemical structure, C23H13Cl2F3N2O, CAS 331261-54-2
2-(2,4-Dichlorostyryl)-3-(3-(trifluoromethyl)phenyl)quinazolin-4(3H)-one
CAS 331261-54-2C23H13Cl2F3N2O
6-Bromo-2-(4-hydroxystyryl)-3-phenylquinazolin-4(3H)-one chemical structure, C22H15BrN2O2, CAS 498535-32-3
6-Bromo-2-(4-hydroxystyryl)-3-phenylquinazolin-4(3H)-one
CAS 498535-32-3C22H15BrN2O2
2-(4-(Dimethylamino)styryl)-3-(2-hydroxyphenyl)quinazolin-4(3H)-one chemical structure, C24H21N3O2, CAS 371933-66-3
2-(4-(Dimethylamino)styryl)-3-(2-hydroxyphenyl)quinazolin-4(3H)-one
CAS 371933-66-3C24H21N3O2
6-Iodo-3-(2-methoxyphenyl)-2-(3-methylstyryl)quinazolin-4(3H)-one chemical structure, C24H19IN2O2, CAS 488089-12-9
6-Iodo-3-(2-methoxyphenyl)-2-(3-methylstyryl)quinazolin-4(3H)-one
CAS 488089-12-9C24H19IN2O2
6-Iodo-3-(3-methoxyphenyl)-2-(4-methylstyryl)quinazolin-4(3H)-one chemical structure, C24H19IN2O2, CAS 499116-55-1
6-Iodo-3-(3-methoxyphenyl)-2-(4-methylstyryl)quinazolin-4(3H)-one
CAS 499116-55-1C24H19IN2O2
3-(2,6-Dichlorophenyl)-2-(2-methylstyryl)quinazolin-4(3H)-one chemical structure, C23H16Cl2N2O, CAS 846579-47-3
3-(2,6-Dichlorophenyl)-2-(2-methylstyryl)quinazolin-4(3H)-one
CAS 846579-47-3C23H16Cl2N2O
2-(4-Fluorostyryl)-6-iodo-3-(m-tolyl)quinazolin-4(3H)-one chemical structure, C23H16FIN2O, CAS 500275-23-0
2-(4-Fluorostyryl)-6-iodo-3-(m-tolyl)quinazolin-4(3H)-one
CAS 500275-23-0C23H16FIN2O
2-(2,5-Dimethoxystyryl)-3-(4-methoxyphenyl)quinazolin-4(3H)-one chemical structure, C25H22N2O4, CAS 342390-47-0
2-(2,5-Dimethoxystyryl)-3-(4-methoxyphenyl)quinazolin-4(3H)-one
CAS 342390-47-0C25H22N2O4