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Murcko scaffold

Ring system with 2 rings and 13 atoms

230 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
230
With full pages
38
Scaffold SMILES

S=C1NC=CC(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold S=C1NC=CC(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 230 chemicals

Allyl 4-(2-ethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C17H20N2O3S, CAS 295807-30-6
Allyl 4-(2-ethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 295807-30-6C17H20N2O3S
Methyl 6-methyl-2-(4-(isopropyl)phenyl)-4-thioxo-2H,3H,5H-3,5-diazinecarboxylate chemical structure, C16H20N2O2S, CAS 313960-57-5
Methyl 6-methyl-2-(4-(isopropyl)phenyl)-4-thioxo-2H,3H,5H-3,5-diazinecarboxylate
CAS 313960-57-5C16H20N2O2S
Butyl 4-(4-dimethylaminophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate chemical structure, C18H25N3O2S, CAS 5605-18-5
Butyl 4-(4-dimethylaminophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
CAS 5605-18-5C18H25N3O2S
Pentyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C17H22N2O2S, CAS 300360-15-0
Pentyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 300360-15-0C17H22N2O2S
Ethyl 6-methyl-2-thioxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C17H22N2O5S, CAS 134074-42-3
Ethyl 6-methyl-2-thioxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 134074-42-3C17H22N2O5S
Ethyl 4-(3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C15H18N2O3S, CAS 292871-43-3
Ethyl 4-(3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 292871-43-3C15H18N2O3S
Ethyl 4-(3,4-dichlorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate chemical structure, C14H14Cl2N2O2S, CAS 5675-97-8
Ethyl 4-(3,4-dichlorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
CAS 5675-97-8C14H14Cl2N2O2S
6-Methyl-2-thioxo-4-p-tolyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester chemical structure, C15H18N2O2S, CAS 185023-34-1
6-Methyl-2-thioxo-4-p-tolyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester
CAS 185023-34-1C15H18N2O2S
2-Ethylbutyl 4-(2,5-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C20H28N2O4S, CAS 300360-11-6
2-Ethylbutyl 4-(2,5-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 300360-11-6C20H28N2O4S
Methyl 4-(4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C13H14N2O3S, CAS 314052-39-6
Methyl 4-(4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 314052-39-6C13H14N2O3S
Ethyl 4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C16H20N2O4S, CAS 315234-80-1
Ethyl 4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 315234-80-1C16H20N2O4S
Methyl 6-methyl-4-(4-methylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate chemical structure, C14H16N2O2S, CAS 134074-41-2
Methyl 6-methyl-4-(4-methylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
CAS 134074-41-2C14H16N2O2S
Methyl 4-(2,3-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C15H18N2O4S, CAS 313392-24-4
Methyl 4-(2,3-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 313392-24-4C15H18N2O4S
Methyl 4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C15H18N2O4S, CAS 333768-43-7
Methyl 4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 333768-43-7C15H18N2O4S
2-Methoxyethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C15H18N2O3S, CAS 324037-31-2
2-Methoxyethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 324037-31-2C15H18N2O3S
2-Methoxyethyl 6-(4-chlorophenyl)-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate chemical structure, C15H17ClN2O3S, CAS 333435-26-0
2-Methoxyethyl 6-(4-chlorophenyl)-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate
CAS 333435-26-0C15H17ClN2O3S
2-Methoxyethyl 4-(3,4-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C17H22N2O5S, CAS 332372-96-0
2-Methoxyethyl 4-(3,4-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 332372-96-0C17H22N2O5S
2-Methoxyethyl 4-(2,5-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C17H22N2O5S, CAS 423152-83-4
2-Methoxyethyl 4-(2,5-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 423152-83-4C17H22N2O5S
2-Methoxyethyl 6-methyl-4-(4-methylphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C16H20N2O3S, CAS 405156-57-2
2-Methoxyethyl 6-methyl-4-(4-methylphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 405156-57-2C16H20N2O3S
Methyl 4-(4-methoxyphenyl)-1,6-dimethyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C15H18N2O3S, CAS 324037-55-0
Methyl 4-(4-methoxyphenyl)-1,6-dimethyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 324037-55-0C15H18N2O3S
5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(2-(difluoromethoxy)phenyl)-6-methyl-2-thioxo-, ethyl ester chemical structure, C15H16F2N2O3S, CAS 121112-80-9
5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(2-(difluoromethoxy)phenyl)-6-methyl-2-thioxo-, ethyl ester
CAS 121112-80-9C15H16F2N2O3S
Methyl 6-(3-methoxyphenyl)-3,4-dimethyl-2-sulfanylidene-1,6-dihydropyrimidine-5-carboxylate chemical structure, C15H18N2O3S, CAS 5976-09-0
Methyl 6-(3-methoxyphenyl)-3,4-dimethyl-2-sulfanylidene-1,6-dihydropyrimidine-5-carboxylate
CAS 5976-09-0C15H18N2O3S
Methyl 6-methyl-4-(4-methylsulfanylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate chemical structure, C14H16N2O2S2, CAS 353519-87-6
Methyl 6-methyl-4-(4-methylsulfanylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
CAS 353519-87-6C14H16N2O2S2
Isopropyl 4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate chemical structure, C17H22N2O4S, CAS 328031-59-0
Isopropyl 4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS 328031-59-0C17H22N2O4S