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Murcko scaffold

Ring system with 2 rings and 13 atoms

230 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
230
With full pages
38
Scaffold SMILES

S=C1NC=CC(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold S=C1NC=CC(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 144 of 230 chemicals

tert-Butyl 4-(2-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate chemical structure, C16H19FN2O2S, CAS 488852-03-5
tert-Butyl 4-(2-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
CAS 488852-03-5C16H19FN2O2S
tert-Butyl 4-(2,5-dimethoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate chemical structure, C18H24N2O4S, CAS 431892-60-3
tert-Butyl 4-(2,5-dimethoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
CAS 431892-60-3C18H24N2O4S
tert-Butyl 4-(3-bromophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate chemical structure, C16H19BrN2O2S, CAS 488802-10-4
tert-Butyl 4-(3-bromophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
CAS 488802-10-4C16H19BrN2O2S
tert-Butyl 6-[4-(dimethylamino)phenyl]-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate chemical structure, C18H25N3O2S, CAS 354792-56-6
tert-Butyl 6-[4-(dimethylamino)phenyl]-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate
CAS 354792-56-6C18H25N3O2S
4-(2-Fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C12H12FN3OS, CAS 347319-69-1
4-(2-Fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 347319-69-1C12H12FN3OS
4-(3-Bromo-4-methoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C13H14BrN3O2S, CAS 347319-24-8
4-(3-Bromo-4-methoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 347319-24-8C13H14BrN3O2S
4-(4-Methoxy-2,5-dimethylphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C15H19N3O2S, CAS 347319-59-9
4-(4-Methoxy-2,5-dimethylphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 347319-59-9C15H19N3O2S
4-(5-Bromo-2,3-dimethoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C14H16BrN3O3S, CAS 347319-19-1
4-(5-Bromo-2,3-dimethoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 347319-19-1C14H16BrN3O3S
4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C13H15N3O3S, CAS 371119-23-2
4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 371119-23-2C13H15N3O3S
4-(5-Bromo-2,4-dimethoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C14H16BrN3O3S, CAS 347319-30-6
4-(5-Bromo-2,4-dimethoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 347319-30-6C14H16BrN3O3S
4-(2-Chlorophenyl)-N,6-dimethyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C13H14ClN3OS, CAS 431941-55-8
4-(2-Chlorophenyl)-N,6-dimethyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 431941-55-8C13H14ClN3OS
Methyl 6-(3,4-diethoxyphenyl)-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate chemical structure, C17H22N2O4S, CAS 431998-40-2
Methyl 6-(3,4-diethoxyphenyl)-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate
CAS 431998-40-2C17H22N2O4S
Methyl 4-(3-methoxy-4-propoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate chemical structure, C17H22N2O4S, CAS 301323-02-4
Methyl 4-(3-methoxy-4-propoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS 301323-02-4C17H22N2O4S
4-(2,4-Dimethoxyphenyl)-N,6-dimethyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C15H19N3O3S, CAS 433258-59-4
4-(2,4-Dimethoxyphenyl)-N,6-dimethyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 433258-59-4C15H19N3O3S
4-(5-Bromo-2,4-dimethoxyphenyl)-N,6-dimethyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C15H18BrN3O3S, CAS 433260-65-2
4-(5-Bromo-2,4-dimethoxyphenyl)-N,6-dimethyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 433260-65-2C15H18BrN3O3S
Methyl 1,2,3,4-tetrahydro-1,6-dimethyl-4-phenyl-2-thioxo-5-pyrimidinecarboxylate chemical structure, C14H16N2O2S, CAS 126827-26-7
Methyl 1,2,3,4-tetrahydro-1,6-dimethyl-4-phenyl-2-thioxo-5-pyrimidinecarboxylate
CAS 126827-26-7C14H16N2O2S
4-(5-Bromo-2,3-dimethoxyphenyl)-N,6-dimethyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C15H18BrN3O3S, CAS 433314-16-0
4-(5-Bromo-2,3-dimethoxyphenyl)-N,6-dimethyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 433314-16-0C15H18BrN3O3S
4-(2,4-Dichlorophenyl)-N,6-dimethyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C13H13Cl2N3OS, CAS 141354-16-7
4-(2,4-Dichlorophenyl)-N,6-dimethyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 141354-16-7C13H13Cl2N3OS
4-(4-Fluorophenyl)-N,6-dimethyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C13H14FN3OS, CAS 433319-42-7
4-(4-Fluorophenyl)-N,6-dimethyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 433319-42-7C13H14FN3OS
Methyl 6-(3-bromo-4-methoxyphenyl)-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate chemical structure, C14H15BrN2O3S, CAS 591764-74-8
Methyl 6-(3-bromo-4-methoxyphenyl)-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate
CAS 591764-74-8C14H15BrN2O3S
Methyl 4-(4-(methoxycarbonyl)phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C15H16N2O4S, CAS 608120-83-8
Methyl 4-(4-(methoxycarbonyl)phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 608120-83-8C15H16N2O4S
Methyl 6-(5-bromo-2-methoxyphenyl)-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate chemical structure, C14H15BrN2O3S, CAS 591761-06-7
Methyl 6-(5-bromo-2-methoxyphenyl)-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate
CAS 591761-06-7C14H15BrN2O3S
4-(5-Bromo-2,3-dimethoxyphenyl)-N,N,6-trimethyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C16H20BrN3O3S, CAS 499112-36-6
4-(5-Bromo-2,3-dimethoxyphenyl)-N,N,6-trimethyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 499112-36-6C16H20BrN3O3S
Prop-2-en-1-yl 3-acetyl-4-(4-tert-butylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C21H26N2O3S, CAS 462069-86-9
Prop-2-en-1-yl 3-acetyl-4-(4-tert-butylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 462069-86-9C21H26N2O3S