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Murcko scaffold

1,3-Dibenzylpyrimidine-2,4-dione scaffold

29 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
29
With full pages
6
Scaffold SMILES

O=c1ccn(Cc2ccccc2)c(=O)n1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,3-Dibenzylpyrimidine-2,4-dione page
Murcko scaffold O=c1ccn(Cc2ccccc2)c(=O)n1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

2,4(1H,3H)-Pyrimidinedione, 5-methyl-1,3-bis((pentafluorophenyl)methyl)- chemical structure, C19H8F10N2O2, CAS 99268-59-4
2,4(1H,3H)-Pyrimidinedione, 5-methyl-1,3-bis((pentafluorophenyl)methyl)-
CAS 99268-59-4C19H8F10N2O2
1,3-Dibenzyl-5-nitropyrimidine-2,4-dione chemical structure, C18H15N3O4, CAS 18592-26-2
1,3-Dibenzyl-5-nitropyrimidine-2,4-dione
CAS 18592-26-2C18H15N3O4
1,3-Dibenzyl-5-[bis(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione chemical structure, C22H25N3O4, CAS 18592-46-6
1,3-Dibenzyl-5-[bis(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione
CAS 18592-46-6C22H25N3O4
4,4'-[(2,4-Dioxopyrimidine-1,3(2H,4H)-diyl)dimethanediyl]dibenzoic acid chemical structure, C20H16N2O6, CAS 4113-96-6
4,4'-[(2,4-Dioxopyrimidine-1,3(2H,4H)-diyl)dimethanediyl]dibenzoic acid
CAS 4113-96-6C20H16N2O6
1,3-Dibenzyl-5-[bis(2-fluoroethyl)amino]pyrimidine-2,4(1H,3H)-dione chemical structure, C22H23F2N3O2, CAS 16869-88-8
1,3-Dibenzyl-5-[bis(2-fluoroethyl)amino]pyrimidine-2,4(1H,3H)-dione
CAS 16869-88-8C22H23F2N3O2
6-Amino-1,3-dibenzyl-5-nitroso-pyrimidine-2,4-dione chemical structure, C18H16N4O3, CAS 112635-84-4
6-Amino-1,3-dibenzyl-5-nitroso-pyrimidine-2,4-dione
CAS 112635-84-4C18H16N4O3
RefChem:357226 chemical structure, C18H17N3O2, CAS 41862-17-3
RefChem:357226
CAS 41862-17-3C18H17N3O2
Dimethyl 4,4'-[(2,4-dioxopyrimidine-1,3(2H,4H)-diyl)dimethanediyl]dibenzoate chemical structure, C22H20N2O6, CAS 4113-94-4
Dimethyl 4,4'-[(2,4-dioxopyrimidine-1,3(2H,4H)-diyl)dimethanediyl]dibenzoate
CAS 4113-94-4C22H20N2O6
1,3-Dibenzyl-5-fluorouracil chemical structure, C18H15FN2O2, CAS 75500-02-6
1,3-Dibenzyl-5-fluorouracil
CAS 75500-02-6C18H15FN2O2
1,3-Dibenzylpyrimidine-2,4-dione chemical structure, C18H16N2O2, CAS 34001-56-4
1,3-Dibenzylpyrimidine-2,4-dione
CAS 34001-56-4C18H16N2O2
5-Fluoro-1,3-bis[(4-fluorophenyl)methyl]pyrimidine-2,4-dione chemical structure, C18H13F3N2O2, CAS 85093-37-4
5-Fluoro-1,3-bis[(4-fluorophenyl)methyl]pyrimidine-2,4-dione
CAS 85093-37-4C18H13F3N2O2
1,3-Dibenzyl-6-methylpyrimidine-2,4(1H,3H)-dione chemical structure, C19H18N2O2, CAS 85102-59-6
1,3-Dibenzyl-6-methylpyrimidine-2,4(1H,3H)-dione
CAS 85102-59-6C19H18N2O2
Hexyl (E)-3-(1,3-dibenzyl-4-methyl-2,6-dioxopyrimidin-5-yl)prop-2-enoate chemical structure, C28H32N2O4, CAS 300804-42-6
Hexyl (E)-3-(1,3-dibenzyl-4-methyl-2,6-dioxopyrimidin-5-yl)prop-2-enoate
CAS 300804-42-6C28H32N2O4
5-Acetyl-1-benzyl-3-(4-fluorobenzyl)-2,4(1H,3H)-pyrimidinedione chemical structure, C20H17FN2O3, CAS 338399-30-7
5-Acetyl-1-benzyl-3-(4-fluorobenzyl)-2,4(1H,3H)-pyrimidinedione
CAS 338399-30-7C20H17FN2O3
1-Benzyl-5-[3-(dimethylamino)acryloyl]-3-(4-fluorobenzyl)-2,4(1H,3H)-pyrimidinedione chemical structure, C23H22FN3O3, CAS 338399-34-1
1-Benzyl-5-[3-(dimethylamino)acryloyl]-3-(4-fluorobenzyl)-2,4(1H,3H)-pyrimidinedione
CAS 338399-34-1C23H22FN3O3
2,4(1H,3H)-Pyrimidinedione, 5-iodo-1,3-bis(phenylmethyl)- chemical structure, C18H15IN2O2, CAS 119125-40-5
2,4(1H,3H)-Pyrimidinedione, 5-iodo-1,3-bis(phenylmethyl)-
CAS 119125-40-5C18H15IN2O2
1,3-Bis(4-methoxybenzyl)-5-fluorouracil chemical structure, C20H19FN2O4, CAS 897304-05-1
1,3-Bis(4-methoxybenzyl)-5-fluorouracil
CAS 897304-05-1C20H19FN2O4
1,3-Dibenzyl-5-[(2-fluoroethyl)amino]pyrimidine-2,4(1H,3H)-dione--hydrogen bromide (1/1) chemical structure, C20H21BrFN3O2, CAS 16869-91-3
1,3-Dibenzyl-5-[(2-fluoroethyl)amino]pyrimidine-2,4(1H,3H)-dione--hydrogen bromide (1/1)
CAS 16869-91-3C20H21BrFN3O2
1,3-Dibenzyl-5-[(2-fluoroethyl)(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione--hydrogen chloride (1/1) chemical structure, C22H25ClFN3O3, CAS 16869-93-5
1,3-Dibenzyl-5-[(2-fluoroethyl)(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione--hydrogen chloride (1/1)
CAS 16869-93-5C22H25ClFN3O3
1,3-Bis[(4-chlorophenyl)methyl]pyrimidine-2,4(1H,3H)-dione chemical structure, C18H14Cl2N2O2, CAS 500114-85-2
1,3-Bis[(4-chlorophenyl)methyl]pyrimidine-2,4(1H,3H)-dione
CAS 500114-85-2C18H14Cl2N2O2
6-Chloro-1,3-bis[(4-methoxyphenyl)methyl]pyrimidine-2,4-dione chemical structure, C20H19ClN2O4, CAS 911368-98-4
6-Chloro-1,3-bis[(4-methoxyphenyl)methyl]pyrimidine-2,4-dione
CAS 911368-98-4C20H19ClN2O4
6-Iodo-1,3-bis[(4-methoxyphenyl)methyl]pyrimidine-2,4-dione chemical structure, C20H19IN2O4, CAS 911368-94-0
6-Iodo-1,3-bis[(4-methoxyphenyl)methyl]pyrimidine-2,4-dione
CAS 911368-94-0C20H19IN2O4
6-(Chloromethyl)-1,3-bis[(4-methoxyphenyl)methyl]pyrimidine-2,4-dione chemical structure, C21H21ClN2O4, CAS 944114-47-0
6-(Chloromethyl)-1,3-bis[(4-methoxyphenyl)methyl]pyrimidine-2,4-dione
CAS 944114-47-0C21H21ClN2O4
1,3-Dibenzyl-5-bromo-6-chloropyrimidine-2,4(1H,3H)-dione chemical structure, C18H14BrClN2O2, CAS 917396-15-7
1,3-Dibenzyl-5-bromo-6-chloropyrimidine-2,4(1H,3H)-dione
CAS 917396-15-7C18H14BrClN2O2