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Murcko scaffold

Ring system with 3 rings and 21 atoms

26 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
26
With full pages
5
Scaffold SMILES

O=C(Nc1ccc(Cc2ccccc2)s1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccc(Cc2ccccc2)s1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

2-(Benzoylamino)-5-benzyl-4-methyl-3-thiophenecarboxamide chemical structure, C20H18N2O2S, CAS 314284-22-5
2-(Benzoylamino)-5-benzyl-4-methyl-3-thiophenecarboxamide
CAS 314284-22-5C20H18N2O2S
5-Benzyl-4-methyl-2-[(2-methylbenzoyl)amino]-3-thiophenecarboxamide chemical structure, C21H20N2O2S, CAS 314284-66-7
5-Benzyl-4-methyl-2-[(2-methylbenzoyl)amino]-3-thiophenecarboxamide
CAS 314284-66-7C21H20N2O2S
5-Benzyl-2-[(4-fluorobenzoyl)amino]-4-methyl-3-thiophenecarboxamide chemical structure, C20H17FN2O2S, CAS 307339-96-4
5-Benzyl-2-[(4-fluorobenzoyl)amino]-4-methyl-3-thiophenecarboxamide
CAS 307339-96-4C20H17FN2O2S
5-Benzyl-4-methyl-2-[(4-nitrobenzoyl)amino]thiophene-3-carboxamide chemical structure, C20H17N3O4S, CAS 304668-12-0
5-Benzyl-4-methyl-2-[(4-nitrobenzoyl)amino]thiophene-3-carboxamide
CAS 304668-12-0C20H17N3O4S
5-Benzyl-4-methyl-2-[(2-nitrobenzoyl)amino]thiophene-3-carboxamide chemical structure, C20H17N3O4S, CAS 304667-54-7
5-Benzyl-4-methyl-2-[(2-nitrobenzoyl)amino]thiophene-3-carboxamide
CAS 304667-54-7C20H17N3O4S
Methyl 5-benzyl-2-[(3-chlorobenzoyl)amino]thiophene-3-carboxylate chemical structure, C20H16ClNO3S, CAS 444940-09-4
Methyl 5-benzyl-2-[(3-chlorobenzoyl)amino]thiophene-3-carboxylate
CAS 444940-09-4C20H16ClNO3S
5-Benzyl-2-[(2-bromobenzoyl)amino]-4-methyl-3-thiophenecarboxamide chemical structure, C20H17BrN2O2S, CAS 304668-03-9
5-Benzyl-2-[(2-bromobenzoyl)amino]-4-methyl-3-thiophenecarboxamide
CAS 304668-03-9C20H17BrN2O2S
5-Benzyl-2-[(4-methoxybenzoyl)amino]-4-methyl-3-thiophenecarboxamide chemical structure, C21H20N2O3S, CAS 314285-22-8
5-Benzyl-2-[(4-methoxybenzoyl)amino]-4-methyl-3-thiophenecarboxamide
CAS 314285-22-8C21H20N2O3S
5-Benzyl-4-methyl-2-[(3,4,5-trimethoxybenzoyl)amino]thiophene-3-carboxamide chemical structure, C23H24N2O5S, CAS 433251-26-4
5-Benzyl-4-methyl-2-[(3,4,5-trimethoxybenzoyl)amino]thiophene-3-carboxamide
CAS 433251-26-4C23H24N2O5S
5-Benzyl-2-[(3-bromo-4-methylbenzoyl)amino]-4-methyl-3-thiophenecarboxamide chemical structure, C21H19BrN2O2S, CAS 443668-09-5
5-Benzyl-2-[(3-bromo-4-methylbenzoyl)amino]-4-methyl-3-thiophenecarboxamide
CAS 443668-09-5C21H19BrN2O2S
5-Benzyl-2-[(4-tert-butylbenzoyl)amino]-4-methylthiophene-3-carboxamide chemical structure, C24H26N2O2S, CAS 444114-77-6
5-Benzyl-2-[(4-tert-butylbenzoyl)amino]-4-methylthiophene-3-carboxamide
CAS 444114-77-6C24H26N2O2S
5-Benzyl-4-methyl-2-[(3-methylbenzoyl)amino]-3-thiophenecarboxamide chemical structure, C21H20N2O2S, CAS 314282-04-7
5-Benzyl-4-methyl-2-[(3-methylbenzoyl)amino]-3-thiophenecarboxamide
CAS 314282-04-7C21H20N2O2S
2-({[3-(Aminocarbonyl)-5-benzyl-4-methyl-2-thienyl]amino}carbonyl)benzoic acid chemical structure, C21H18N2O4S, CAS 314281-77-1
2-({[3-(Aminocarbonyl)-5-benzyl-4-methyl-2-thienyl]amino}carbonyl)benzoic acid
CAS 314281-77-1C21H18N2O4S
Methyl 2-(benzoylamino)-5-benzyl-4-methyl-3-thiophenecarboxylate chemical structure, C21H19NO3S, CAS 308293-37-0
Methyl 2-(benzoylamino)-5-benzyl-4-methyl-3-thiophenecarboxylate
CAS 308293-37-0C21H19NO3S
Methyl 5-benzyl-2-[(4-fluorobenzoyl)amino]-4-methyl-3-thiophenecarboxylate chemical structure, C21H18FNO3S, CAS 314283-55-1
Methyl 5-benzyl-2-[(4-fluorobenzoyl)amino]-4-methyl-3-thiophenecarboxylate
CAS 314283-55-1C21H18FNO3S
Methyl 5-benzyl-4-methyl-2-[(2-nitrobenzoyl)amino]thiophene-3-carboxylate chemical structure, C21H18N2O5S, CAS 314283-58-4
Methyl 5-benzyl-4-methyl-2-[(2-nitrobenzoyl)amino]thiophene-3-carboxylate
CAS 314283-58-4C21H18N2O5S
5-Benzyl-4-methyl-2-[(4-methylbenzoyl)amino]-3-thiophenecarboxamide chemical structure, C21H20N2O2S, CAS 314284-63-4
5-Benzyl-4-methyl-2-[(4-methylbenzoyl)amino]-3-thiophenecarboxamide
CAS 314284-63-4C21H20N2O2S
Ethyl 5-benzyl-2-({3-nitro-4-methoxybenzoyl}amino)-3-thiophenecarboxylate chemical structure, C22H20N2O6S, CAS 495395-35-2
Ethyl 5-benzyl-2-({3-nitro-4-methoxybenzoyl}amino)-3-thiophenecarboxylate
CAS 495395-35-2C22H20N2O6S
Ethyl 5-benzyl-2-({4-nitrobenzoyl}amino)-3-thiophenecarboxylate chemical structure, C21H18N2O5S, CAS 492441-66-4
Ethyl 5-benzyl-2-({4-nitrobenzoyl}amino)-3-thiophenecarboxylate
CAS 492441-66-4C21H18N2O5S
5-Benzyl-2-[(3-bromo-4-methoxybenzoyl)amino]-4-methylthiophene-3-carboxamide chemical structure, C21H19BrN2O3S, CAS 433311-09-2
5-Benzyl-2-[(3-bromo-4-methoxybenzoyl)amino]-4-methylthiophene-3-carboxamide
CAS 433311-09-2C21H19BrN2O3S
Methyl 5-benzyl-4-methyl-2-[(3-methylbenzoyl)amino]-3-thiophenecarboxylate chemical structure, C22H21NO3S, CAS 314283-56-2
Methyl 5-benzyl-4-methyl-2-[(3-methylbenzoyl)amino]-3-thiophenecarboxylate
CAS 314283-56-2C22H21NO3S
Methyl 5-benzyl-2-[(2,4-dichlorobenzoyl)amino]-4-methyl-3-thiophenecarboxylate chemical structure, C21H17Cl2NO3S, CAS 314283-53-9
Methyl 5-benzyl-2-[(2,4-dichlorobenzoyl)amino]-4-methyl-3-thiophenecarboxylate
CAS 314283-53-9C21H17Cl2NO3S
5-Benzyl-2-[(3-iodo-4-methylbenzoyl)amino]-4-methylthiophene-3-carboxamide chemical structure, C21H19IN2O2S, CAS 497089-85-7
5-Benzyl-2-[(3-iodo-4-methylbenzoyl)amino]-4-methylthiophene-3-carboxamide
CAS 497089-85-7C21H19IN2O2S
5-Benzyl-2-[(2,4-dichlorobenzoyl)amino]-4-methyl-3-thiophenecarboxamide chemical structure, C20H16Cl2N2O2S, CAS 314284-77-0
5-Benzyl-2-[(2,4-dichlorobenzoyl)amino]-4-methyl-3-thiophenecarboxamide
CAS 314284-77-0C20H16Cl2N2O2S