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Murcko scaffold

Ring system with 3 rings and 23 atoms

23 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 23
Chemicals: 23
With full pages: 7

Scaffold SMILES

O=C(NN1C(=O)C(=Cc2ccccc2)SC1=S)c1cccnc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(NN1C(=O)C(=Cc2ccccc2)SC1=S)c1cccnc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

N-[5-(3-Ethoxy-4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]nicotinamide chemical structure, C18H15N3O4S2, CAS 304861-26-5

N-[5-(3-Ethoxy-4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]nicotinamide

CAS 304861-26-5C₁₈H₁₅N₃O₄S₂

(Z)-N-(5-(2-Methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)nicotinamide chemical structure, C17H13N3O3S2, CAS 6045-55-2

(Z)-N-(5-(2-Methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)nicotinamide

CAS 6045-55-2C₁₇H₁₃N₃O₃S₂

N-[5-(4-Methoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide chemical structure, C17H13N3O3S2, CAS 301687-46-7

N-[5-(4-Methoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide

CAS 301687-46-7C₁₇H₁₃N₃O₃S₂

N-[5-(3-Bromo-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide chemical structure, C16H10BrN3O2S2, CAS 301687-56-9

N-[5-(3-Bromo-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide

CAS 301687-56-9C₁₆H₁₀BrN₃O₂S₂

N-[5-(2-Chloro-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide chemical structure, C16H10ClN3O2S2, CAS 301687-49-0

N-[5-(2-Chloro-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide

CAS 301687-49-0C₁₆H₁₀ClN₃O₂S₂

N-(5-Benzylidene-4-oxo-2-thioxo-thiazolidin-3-yl)-nicotinamide chemical structure, C16H11N3O2S2, CAS 301687-42-3

N-(5-Benzylidene-4-oxo-2-thioxo-thiazolidin-3-yl)-nicotinamide

CAS 301687-42-3C₁₆H₁₁N₃O₂S₂

N-[5-(3-Methoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide chemical structure, C17H13N3O3S2, CAS 301687-45-6

N-[5-(3-Methoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide

CAS 301687-45-6C₁₇H₁₃N₃O₃S₂

N-[5-(4-Methyl-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide chemical structure, C17H13N3O2S2, CAS 301687-43-4

N-[5-(4-Methyl-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide

CAS 301687-43-4C₁₇H₁₃N₃O₂S₂

N-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide chemical structure, C18H15N3O4S2, CAS 301687-47-8

N-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide

CAS 301687-47-8C₁₈H₁₅N₃O₄S₂

(Z)-N-(4-Oxo-2-thioxo-5-(3,4,5-trimethoxybenzylidene)thiazolidin-3-yl)nicotinamide chemical structure, C19H17N3O5S2, CAS 301687-48-9

(Z)-N-(4-Oxo-2-thioxo-5-(3,4,5-trimethoxybenzylidene)thiazolidin-3-yl)nicotinamide

CAS 301687-48-9C₁₉H₁₇N₃O₅S₂

N-[(5Z)-5-(2,6-Dichlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pyridine-3-carboxamide chemical structure, C16H9Cl2N3O2S2, CAS 301687-52-5

N-[(5Z)-5-(2,6-Dichlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pyridine-3-carboxamide

CAS 301687-52-5C₁₆H₉Cl₂N₃O₂S₂

N-[(5Z)-5-[(3-Fluorophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]pyridine-3-carboxamide chemical structure, C16H10FN3O2S2, CAS 301687-54-7

N-[(5Z)-5-[(3-Fluorophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]pyridine-3-carboxamide

CAS 301687-54-7C₁₆H₁₀FN₃O₂S₂

N-[5-(4-Chloro-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide chemical structure, C16H10ClN3O2S2, CAS 301687-50-3

N-[5-(4-Chloro-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide

CAS 301687-50-3C₁₆H₁₀ClN₃O₂S₂

N-[5-(2,4-Dichloro-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide chemical structure, C16H9Cl2N3O2S2, CAS 301687-51-4

N-[5-(2,4-Dichloro-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide

CAS 301687-51-4C₁₆H₉Cl₂N₃O₂S₂

N-[5-(4-Fluoro-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide chemical structure, C16H10FN3O2S2, CAS 301687-53-6

N-[5-(4-Fluoro-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide

CAS 301687-53-6C₁₆H₁₀FN₃O₂S₂

N-[5-(4-Bromo-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide chemical structure, C16H10BrN3O2S2, CAS 301687-55-8

N-[5-(4-Bromo-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-nicotinamide

CAS 301687-55-8C₁₆H₁₀BrN₃O₂S₂

(Z)-N-(5-(2,4-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)nicotinamide chemical structure, C18H15N3O4S2, CAS 848928-56-3

(Z)-N-(5-(2,4-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)nicotinamide

CAS 848928-56-3C₁₈H₁₅N₃O₄S₂

N-[(5Z)-5-(4-Hydroxy-3-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pyridine-3-carboxamide chemical structure, C17H13N3O4S2, CAS 848992-60-9

N-[(5Z)-5-(4-Hydroxy-3-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pyridine-3-carboxamide

CAS 848992-60-9C₁₇H₁₃N₃O₄S₂

N-[(5Z)-5-(4-Ethoxy-3-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pyridine-3-carboxamide chemical structure, C19H17N3O4S2, CAS 848993-65-7

N-[(5Z)-5-(4-Ethoxy-3-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pyridine-3-carboxamide

CAS 848993-65-7C₁₉H₁₇N₃O₄S₂

N-{(5Z)-4-oxo-5-[4-(prop-2-en-1-yloxy)benzylidene]-2-thioxo-1,3-thiazolidin-3-yl}pyridine-3-carboxamide chemical structure, C19H15N3O3S2, CAS 861147-27-5

N-{(5Z)-4-oxo-5-[4-(prop-2-en-1-yloxy)benzylidene]-2-thioxo-1,3-thiazolidin-3-yl}pyridine-3-carboxamide

CAS 861147-27-5C₁₉H₁₅N₃O₃S₂

(Z)-N-(5-(4-(Octyloxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)nicotinamide chemical structure, C24H27N3O3S2, CAS 861645-88-7

(Z)-N-(5-(4-(Octyloxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)nicotinamide

CAS 861645-88-7C₂₄H₂₇N₃O₃S₂

N-[(5Z)-5-(2,5-Dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pyridine-3-carboxamide chemical structure, C18H15N3O4S2, CAS 861121-01-9

N-[(5Z)-5-(2,5-Dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]pyridine-3-carboxamide

CAS 861121-01-9C₁₈H₁₅N₃O₄S₂

(Z)-N-(5-(2,3-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)nicotinamide chemical structure, C18H15N3O4S2, CAS 861111-37-7

(Z)-N-(5-(2,3-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)nicotinamide

CAS 861111-37-7C₁₈H₁₅N₃O₄S₂