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Murcko scaffold

Ring system with 3 rings and 23 atoms

186 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
186
With full pages
19
Scaffold SMILES

O=C(NN1C(=O)C(=Cc2ccccc2)SC1=S)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NN1C(=O)C(=Cc2ccccc2)SC1=S)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 186 chemicals

(Z)-2-Chloro-N-(5-(4-hydroxy-3-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamide chemical structure, C18H13ClN2O4S2, CAS 300818-96-6
(Z)-2-Chloro-N-(5-(4-hydroxy-3-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamide
CAS 300818-96-6C18H13ClN2O4S2
(E)-2-Chloro-N-(5-(2,3-dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamide chemical structure, C19H15ClN2O4S2, CAS 301229-57-2
(E)-2-Chloro-N-(5-(2,3-dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamide
CAS 301229-57-2C19H15ClN2O4S2
N-[5-(4-Ethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide chemical structure, C19H16N2O3S2, CAS 301229-55-0
N-[5-(4-Ethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide
CAS 301229-55-0C19H16N2O3S2
N-[(5Z)-5-[(3-Ethoxy-4-hydroxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzamide chemical structure, C19H16N2O4S2, CAS 301229-46-9
N-[(5Z)-5-[(3-Ethoxy-4-hydroxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzamide
CAS 301229-46-9C19H16N2O4S2
(Z)-4-((3-(4-Bromobenzamido)-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzoic acid chemical structure, C18H11BrN2O4S2, CAS 301308-59-8
(Z)-4-((3-(4-Bromobenzamido)-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzoic acid
CAS 301308-59-8C18H11BrN2O4S2
(Z)-4-Bromo-N-(5-(3-ethoxy-4-hydroxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamide chemical structure, C19H15BrN2O4S2, CAS 292169-97-2
(Z)-4-Bromo-N-(5-(3-ethoxy-4-hydroxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamide
CAS 292169-97-2C19H15BrN2O4S2
N-[(5Z)-5-[(4-Methylphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-nitrobenzamide chemical structure, C18H13N3O4S2, CAS 301158-25-8
N-[(5Z)-5-[(4-Methylphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-nitrobenzamide
CAS 301158-25-8C18H13N3O4S2
N-[(5Z)-5-[(2,3-Dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzamide chemical structure, C19H16N2O4S2, CAS 378776-59-1
N-[(5Z)-5-[(2,3-Dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzamide
CAS 378776-59-1C19H16N2O4S2
(Z)-N-(5-(4-Isopropylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamide chemical structure, C20H18N2O2S2, CAS 301229-39-0
(Z)-N-(5-(4-Isopropylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamide
CAS 301229-39-0C20H18N2O2S2
N-[(5Z)-5-(2,5-Dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide chemical structure, C19H16N2O4S2, CAS 301229-49-2
N-[(5Z)-5-(2,5-Dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide
CAS 301229-49-2C19H16N2O4S2
N-[(5Z)-5-[(3,4-Dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzamide chemical structure, C19H16N2O4S2, CAS 301223-52-9
N-[(5Z)-5-[(3,4-Dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzamide
CAS 301223-52-9C19H16N2O4S2
4-Bromo-N-[(5Z)-5-[(3-hydroxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzamide chemical structure, C17H11BrN2O3S2, CAS 299956-07-3
4-Bromo-N-[(5Z)-5-[(3-hydroxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzamide
CAS 299956-07-3C17H11BrN2O3S2
N-[5-(3-Ethoxy-4-hydroxybenzylidene)-4-oxo-2-thioxothiazolidine-3-yl]-2-chlorobenzamide chemical structure, C19H15ClN2O4S2, CAS 299952-84-4
N-[5-(3-Ethoxy-4-hydroxybenzylidene)-4-oxo-2-thioxothiazolidine-3-yl]-2-chlorobenzamide
CAS 299952-84-4C19H15ClN2O4S2
(Z)-3-Hydroxy-N-(5-(4-methylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamide chemical structure, C18H14N2O3S2, CAS 303056-13-5
(Z)-3-Hydroxy-N-(5-(4-methylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzamide
CAS 303056-13-5C18H14N2O3S2
2-Hydroxy-N-[(5Z)-5-(2-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide chemical structure, C18H14N2O4S2, CAS 300827-31-0
2-Hydroxy-N-[(5Z)-5-(2-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide
CAS 300827-31-0C18H14N2O4S2
(Z)-N-(4-Oxo-2-thioxo-5-(3,4,5-trimethoxybenzylidene)thiazolidin-3-yl)benzamide chemical structure, C20H18N2O5S2, CAS 300559-20-0
(Z)-N-(4-Oxo-2-thioxo-5-(3,4,5-trimethoxybenzylidene)thiazolidin-3-yl)benzamide
CAS 300559-20-0C20H18N2O5S2
N-[(5Z)-5-(3-Methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide chemical structure, C18H14N2O3S2, CAS 301691-00-9
N-[(5Z)-5-(3-Methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide
CAS 301691-00-9C18H14N2O3S2
2-Bromo-N-[(5Z)-5-(4-hydroxy-3-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide chemical structure, C18H13BrN2O4S2, CAS 300559-38-0
2-Bromo-N-[(5Z)-5-(4-hydroxy-3-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide
CAS 300559-38-0C18H13BrN2O4S2
2-Bromo-N-[(5Z)-5-(2-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide chemical structure, C18H13BrN2O3S2, CAS 300559-29-9
2-Bromo-N-[(5Z)-5-(2-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide
CAS 300559-29-9C18H13BrN2O3S2
N-[(5Z)-5-(2-Methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide chemical structure, C18H14N2O3S2, CAS 301691-02-1
N-[(5Z)-5-(2-Methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide
CAS 301691-02-1C18H14N2O3S2
N-[(5E)-5-(2-Ethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-2-methylbenzamide chemical structure, C20H18N2O3S2, CAS 301692-10-4
N-[(5E)-5-(2-Ethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-2-methylbenzamide
CAS 301692-10-4C20H18N2O3S2
2-Bromo-N-[(5Z)-5-(4-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide chemical structure, C18H13BrN2O3S2, CAS 300559-27-7
2-Bromo-N-[(5Z)-5-(4-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide
CAS 300559-27-7C18H13BrN2O3S2
2-Bromo-N-[(5Z)-5-(3,4-dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide chemical structure, C19H15BrN2O4S2, CAS 300559-31-3
2-Bromo-N-[(5Z)-5-(3,4-dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide
CAS 300559-31-3C19H15BrN2O4S2
2-Bromo-N-[(5Z)-5-(3-ethoxy-4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide chemical structure, C19H15BrN2O4S2, CAS 300559-40-4
2-Bromo-N-[(5Z)-5-(3-ethoxy-4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzamide
CAS 300559-40-4C19H15BrN2O4S2