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Murcko scaffold

Ring system with 3 rings and 24 atoms

26 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
26
With full pages
22
Scaffold SMILES

O=C1C(=Cc2ccccc2)SC(=S)N1NS(=O)(=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=Cc2ccccc2)SC(=S)N1NS(=O)(=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

(Z)-4-Methyl-N-(5-(4-methylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzenesulfonamide chemical structure, C18H16N2O3S3, CAS 301222-92-4
(Z)-4-Methyl-N-(5-(4-methylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzenesulfonamide
CAS 301222-92-4C18H16N2O3S3
5-(Phenylmethylene)-3-[(phenylsulfonyl)amino]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C16H12N2O3S3, CAS 5366-47-2
5-(Phenylmethylene)-3-[(phenylsulfonyl)amino]-2-thioxo-1,3-thiazolidin-4-one
CAS 5366-47-2C16H12N2O3S3
N-[(5Z)-5-[(4-Hydroxy-3-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzenesulfonamide chemical structure, C17H14N2O5S3, CAS 300818-71-7
N-[(5Z)-5-[(4-Hydroxy-3-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzenesulfonamide
CAS 300818-71-7C17H14N2O5S3
(Z)-N-(5-(4-Fluorobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-4-methylbenzenesulfonamide chemical structure, C17H13FN2O3S3, CAS 301222-93-5
(Z)-N-(5-(4-Fluorobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-4-methylbenzenesulfonamide
CAS 301222-93-5C17H13FN2O3S3
N-[(5Z)-5-[(2,4-Dichlorophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-4-methylbenzenesulfonamide chemical structure, C17H12Cl2N2O3S3, CAS 301222-95-7
N-[(5Z)-5-[(2,4-Dichlorophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-4-methylbenzenesulfonamide
CAS 301222-95-7C17H12Cl2N2O3S3
N-[(5Z)-5-[(3-Ethoxy-4-hydroxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzenesulfonamide chemical structure, C18H16N2O5S3, CAS 847272-53-1
N-[(5Z)-5-[(3-Ethoxy-4-hydroxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzenesulfonamide
CAS 847272-53-1C18H16N2O5S3
N-[(5Z)-5-(3-Ethoxy-4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-4-methylbenzenesulfonamide chemical structure, C19H18N2O5S3, CAS 301222-96-8
N-[(5Z)-5-(3-Ethoxy-4-hydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-4-methylbenzenesulfonamide
CAS 301222-96-8C19H18N2O5S3
4-Methyl-N-{(5Z)-4-oxo-5-[4-(prop-2-en-1-yloxy)benzylidene]-2-thioxo-1,3-thiazolidin-3-yl}benzenesulfonamide chemical structure, C20H18N2O4S3, CAS 846593-94-0
4-Methyl-N-{(5Z)-4-oxo-5-[4-(prop-2-en-1-yloxy)benzylidene]-2-thioxo-1,3-thiazolidin-3-yl}benzenesulfonamide
CAS 846593-94-0C20H18N2O4S3
N-[(5Z)-5-(4-Fluorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide chemical structure, C16H11FN2O3S3, CAS 366807-86-5
N-[(5Z)-5-(4-Fluorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide
CAS 366807-86-5C16H11FN2O3S3
N-[(5Z)-5-(2-Methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide chemical structure, C17H14N2O4S3, CAS 847175-55-7
N-[(5Z)-5-(2-Methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide
CAS 847175-55-7C17H14N2O4S3
N-[(5Z)-5-[(2,4-Dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzenesulfonamide chemical structure, C18H16N2O5S3, CAS 844832-69-5
N-[(5Z)-5-[(2,4-Dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzenesulfonamide
CAS 844832-69-5C18H16N2O5S3
N-[(5Z)-5-(4-Ethoxy-3-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide chemical structure, C19H18N2O5S3, CAS 844836-18-6
N-[(5Z)-5-(4-Ethoxy-3-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide
CAS 844836-18-6C19H18N2O5S3
N-[(5Z)-5-(2,5-Dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-4-methylbenzenesulfonamide chemical structure, C19H18N2O5S3, CAS 845628-69-5
N-[(5Z)-5-(2,5-Dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-4-methylbenzenesulfonamide
CAS 845628-69-5C19H18N2O5S3
N-[(5Z)-5-[(2,3-Dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzenesulfonamide chemical structure, C18H16N2O5S3, CAS 845653-40-9
N-[(5Z)-5-[(2,3-Dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzenesulfonamide
CAS 845653-40-9C18H16N2O5S3
N-[(5Z)-5-(2,4-Dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-4-methylbenzenesulfonamide chemical structure, C19H18N2O5S3, CAS 848205-66-3
N-[(5Z)-5-(2,4-Dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-4-methylbenzenesulfonamide
CAS 848205-66-3C19H18N2O5S3
N-[(5Z)-4-Oxo-2-thioxo-5-(3,4,5-trimethoxybenzylidene)-1,3-thiazolidin-3-yl]benzenesulfonamide chemical structure, C19H18N2O6S3, CAS 848212-11-3
N-[(5Z)-4-Oxo-2-thioxo-5-(3,4,5-trimethoxybenzylidene)-1,3-thiazolidin-3-yl]benzenesulfonamide
CAS 848212-11-3C19H18N2O6S3
4-Methyl-N-[(5Z)-4-oxo-2-sulfanylidene-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]benzenesulfonamide chemical structure, C20H20N2O6S3, CAS 848730-24-5
4-Methyl-N-[(5Z)-4-oxo-2-sulfanylidene-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]benzenesulfonamide
CAS 848730-24-5C20H20N2O6S3
N-[(5Z)-4-Oxo-5-[(4-prop-2-enoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-3-yl]benzenesulfonamide chemical structure, C19H16N2O4S3, CAS 848735-33-1
N-[(5Z)-4-Oxo-5-[(4-prop-2-enoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-3-yl]benzenesulfonamide
CAS 848735-33-1C19H16N2O4S3
N-[(5Z)-5-[(4-Hydroxy-3-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-4-methylbenzenesulfonamide chemical structure, C18H16N2O5S3, CAS 359898-57-0
N-[(5Z)-5-[(4-Hydroxy-3-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-4-methylbenzenesulfonamide
CAS 359898-57-0C18H16N2O5S3
N-[(5Z)-5-(3-Fluorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide chemical structure, C16H11FN2O3S3, CAS 849025-71-4
N-[(5Z)-5-(3-Fluorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide
CAS 849025-71-4C16H11FN2O3S3
N-[(5Z)-5-(2,3-Dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-4-methylbenzenesulfonamide chemical structure, C19H18N2O5S3, CAS 849031-98-7
N-[(5Z)-5-(2,3-Dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-4-methylbenzenesulfonamide
CAS 849031-98-7C19H18N2O5S3
4-Methyl-N-{(5Z)-5-[4-(octyloxy)benzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}benzenesulfonamide chemical structure, C25H30N2O4S3, CAS 848741-91-3
4-Methyl-N-{(5Z)-5-[4-(octyloxy)benzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}benzenesulfonamide
CAS 848741-91-3C25H30N2O4S3
N-{(5Z)-5-[4-(octyloxy)benzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}benzenesulfonamide chemical structure, C24H28N2O4S3, CAS 845985-87-7
N-{(5Z)-5-[4-(octyloxy)benzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}benzenesulfonamide
CAS 845985-87-7C24H28N2O4S3
N-[(5Z)-5-(2,5-Dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide chemical structure, C18H16N2O5S3, CAS 861116-28-1
N-[(5Z)-5-(2,5-Dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide
CAS 861116-28-1C18H16N2O5S3