CompoundList
Sign in
Murcko scaffold

Ring system with 3 rings and 22 atoms

57 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
57
With full pages
8
Scaffold SMILES

O=C1C(=Cc2ccccc2)SC(=S)N1CCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=Cc2ccccc2)SC(=S)N1CCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 57 chemicals

5-(2-Methoxybenzylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C19H17NO2S2, CAS 324565-32-4
5-(2-Methoxybenzylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 324565-32-4C19H17NO2S2
5-[4-(Dimethylamino)benzylidene]-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H20N2OS2, CAS 302823-94-5
5-[4-(Dimethylamino)benzylidene]-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 302823-94-5C20H20N2OS2
(5Z)-5-(3-Ethoxy-4-hydroxybenzylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H19NO3S2, CAS 324565-34-6
(5Z)-5-(3-Ethoxy-4-hydroxybenzylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 324565-34-6C20H19NO3S2
5-(4-Methylbenzylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C19H17NOS2, CAS 302823-96-7
5-(4-Methylbenzylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 302823-96-7C19H17NOS2
(5Z)-5-(2,4-Dimethoxybenzylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H19NO3S2, CAS 431998-99-1
(5Z)-5-(2,4-Dimethoxybenzylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 431998-99-1C20H19NO3S2
(Z)-3-Phenethyl-2-thioxo-5-(3,4,5-trimethoxybenzylidene)thiazolidin-4-one chemical structure, C21H21NO4S2, CAS 432002-07-8
(Z)-3-Phenethyl-2-thioxo-5-(3,4,5-trimethoxybenzylidene)thiazolidin-4-one
CAS 432002-07-8C21H21NO4S2
(5Z)-5-(3-Ethoxy-2-hydroxybenzylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H19NO3S2, CAS 431926-44-2
(5Z)-5-(3-Ethoxy-2-hydroxybenzylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 431926-44-2C20H19NO3S2
5-(4-Hydroxy-3-methoxy-benzylidene)-3-phenethyl-2-thioxo-thiazolidin-4-one chemical structure, C19H17NO3S2, CAS 312935-75-4
5-(4-Hydroxy-3-methoxy-benzylidene)-3-phenethyl-2-thioxo-thiazolidin-4-one
CAS 312935-75-4C19H17NO3S2
(Z)-5-(4-Methoxybenzylidene)-3-phenethyl-2-thioxothiazolidin-4-one chemical structure, C19H17NO2S2, CAS 302823-98-9
(Z)-5-(4-Methoxybenzylidene)-3-phenethyl-2-thioxothiazolidin-4-one
CAS 302823-98-9C19H17NO2S2
5-(2,4-Dichloro-benzylidene)-3-phenethyl-2-thioxo-thiazolidin-4-one chemical structure, C18H13Cl2NOS2, CAS 306732-77-4
5-(2,4-Dichloro-benzylidene)-3-phenethyl-2-thioxo-thiazolidin-4-one
CAS 306732-77-4C18H13Cl2NOS2
(Z)-5-(3-Nitrobenzylidene)-3-phenethyl-2-thioxothiazolidin-4-one chemical structure, C18H14N2O3S2, CAS 302824-50-6
(Z)-5-(3-Nitrobenzylidene)-3-phenethyl-2-thioxothiazolidin-4-one
CAS 302824-50-6C18H14N2O3S2
(Z)-5-(4-Fluorobenzylidene)-3-phenethyl-2-thioxothiazolidin-4-one chemical structure, C18H14FNOS2, CAS 431940-77-1
(Z)-5-(4-Fluorobenzylidene)-3-phenethyl-2-thioxothiazolidin-4-one
CAS 431940-77-1C18H14FNOS2
(5Z)-5-(2,6-Dichlorobenzylidene)-3-[2-(3,4-dimethoxyphenyl)ethyl]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H17Cl2NO3S2, CAS 324564-51-4
(5Z)-5-(2,6-Dichlorobenzylidene)-3-[2-(3,4-dimethoxyphenyl)ethyl]-2-thioxo-1,3-thiazolidin-4-one
CAS 324564-51-4C20H17Cl2NO3S2
(Z)-5-(4-(Isopentyloxy)-3-methoxybenzylidene)-3-phenethyl-2-thioxothiazolidin-4-one chemical structure, C24H27NO3S2, CAS 380878-97-7
(Z)-5-(4-(Isopentyloxy)-3-methoxybenzylidene)-3-phenethyl-2-thioxothiazolidin-4-one
CAS 380878-97-7C24H27NO3S2
5-(4-Chloro-benzylidene)-3-phenethyl-2-thioxo-thiazolidin-4-one chemical structure, C18H14ClNOS2, CAS 302824-54-0
5-(4-Chloro-benzylidene)-3-phenethyl-2-thioxo-thiazolidin-4-one
CAS 302824-54-0C18H14ClNOS2
5-(2,6-Dichloro-benzylidene)-3-phenethyl-2-thioxo-thiazolidin-4-one chemical structure, C18H13Cl2NOS2, CAS 324564-33-2
5-(2,6-Dichloro-benzylidene)-3-phenethyl-2-thioxo-thiazolidin-4-one
CAS 324564-33-2C18H13Cl2NOS2
(Z)-5-(4-(Allyloxy)benzylidene)-3-phenethyl-2-thioxothiazolidin-4-one chemical structure, C21H19NO2S2, CAS 431065-83-7
(Z)-5-(4-(Allyloxy)benzylidene)-3-phenethyl-2-thioxothiazolidin-4-one
CAS 431065-83-7C21H19NO2S2
(5Z)-3-[2-(4-Methoxyphenyl)ethyl]-2-thioxo-5-(3,4,5-trimethoxybenzylidene)-1,3-thiazolidin-4-one chemical structure, C22H23NO5S2, CAS 695210-20-9
(5Z)-3-[2-(4-Methoxyphenyl)ethyl]-2-thioxo-5-(3,4,5-trimethoxybenzylidene)-1,3-thiazolidin-4-one
CAS 695210-20-9C22H23NO5S2
(5Z)-5-(2,4-Dimethoxybenzylidene)-3-[2-(4-methoxyphenyl)ethyl]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C21H21NO4S2, CAS 843625-92-3
(5Z)-5-(2,4-Dimethoxybenzylidene)-3-[2-(4-methoxyphenyl)ethyl]-2-thioxo-1,3-thiazolidin-4-one
CAS 843625-92-3C21H21NO4S2
(5E)-5-[(4-Chlorophenyl)methylidene]-3-[2-(3,4-dimethoxyphenyl)ethyl]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H18ClNO3S2, CAS 438459-79-1
(5E)-5-[(4-Chlorophenyl)methylidene]-3-[2-(3,4-dimethoxyphenyl)ethyl]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 438459-79-1C20H18ClNO3S2
(5E)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-[(3-nitrophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H18N2O5S2, CAS 324564-74-1
(5E)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-[(3-nitrophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 324564-74-1C20H18N2O5S2
(5E)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-[(3,4-dimethoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C22H23NO5S2, CAS 312937-17-0
(5E)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-[(3,4-dimethoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 312937-17-0C22H23NO5S2
(5Z)-5-(4-Bromobenzylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C18H14BrNOS2, CAS 302824-52-8
(5Z)-5-(4-Bromobenzylidene)-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one
CAS 302824-52-8C18H14BrNOS2
(5E)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-[(3-fluorophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H18FNO3S2, CAS 861427-73-8
(5E)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-[(3-fluorophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 861427-73-8C20H18FNO3S2